Pomi-T Supplement & PSA Levels: Clinical Trial Evidence for Prostate Cancer

Quick Answer

Does Pomi-T lower PSA? Yes, according to a major clinical trial. Men taking Pomi-T had 14.7% PSA rise vs. 78.5% in placebo—a significant difference. 46% of Pomi-T users had stable or reduced PSA vs. only 14% on placebo.

What is Pomi-T?

Supplement Overview

  • Type: Polyphenol-rich whole food supplement
  • Key ingredients: Pomegranate, green tea, broccoli, turmeric
  • Form: Capsules
  • Developed: UK-based research team
  • Purpose: Support prostate health and slow PSA progression

Active Compounds

Ingredient Key Compounds Benefits
Pomegranate Ellagic acid, punicalagins Antioxidant, anti-inflammatory
Green tea EGCG, catechins Antioxidant, anti-cancer properties
Broccoli Sulforaphane, indoles Detoxification, anti-cancer
Turmeric Curcumin Anti-inflammatory, antioxidant

How It Works

  • Rich in polyphenols (plant antioxidants)
  • Reduces oxidative stress
  • Anti-inflammatory effects
  • May slow cancer cell growth
  • Supports immune function

PSA: What You Need to Know

What is PSA?

PSA = Prostate-Specific Antigen
  • Protein produced by prostate gland
  • Found in blood
  • Used to monitor prostate cancer
  • Also elevated in benign prostate conditions

PSA Levels

PSA Level Interpretation
<4 ng/mL Normal
4-10 ng/mL Borderline; further testing needed
>10 ng/mL Elevated; possible cancer

PSA Velocity (Rate of Rise)

What It Means:
  • PSA rise over time (e.g., per year)
  • Faster rise = more aggressive disease
  • Used to predict cancer progression
Example:
  • PSA rising 0.5 ng/mL/year = slow progression
  • PSA rising 2 ng/mL/year = faster progression

Active Surveillance

Definition: Monitoring low-risk prostate cancer without immediate treatment
Typical approach:
  • PSA tests every 3-6 months
  • Digital rectal exam (DRE)
  • Repeat biopsy if PSA rises significantly
  • Treatment if disease progresses
Goal: Avoid unnecessary treatment while catching progression early.

The Pomi-T Clinical Trial

Study Design

UK NCRN Pomi-T Study (Thomas et al., 2014)
Type: Double-blind, placebo-controlled randomized trial (gold standard)
Population:
  • Men with localized prostate cancer
  • On active surveillance
  • PSA <10 ng/mL at baseline
Duration: 6 months
Groups:
  • Pomi-T group: Polyphenol supplement (n=~100)
  • Placebo group: Inactive pill (n=~100)

Key Results

Primary Outcome: PSA Progression
Measure Pomi-T Placebo Difference
Median PSA rise 14.7% 78.5% 63.8% lower
Stable/reduced PSA 46% 14% 32% higher
PSA progression 54% 86% 32% lower

Statistical significance: p <0.001 (highly significant)

Clinical Implications

✅ Pomi-T users had 5x lower PSA rise
✅ 46% achieved PSA stability (vs. 14% placebo)
✅ Fewer men left surveillance due to disease progression
✅ Well-tolerated with minimal side effects

Evidence Quality

Strengths: ✓ Double-blind design (reduces bias)
✓ Placebo-controlled (true comparison)
✓ Randomized (balanced groups)
✓ Adequate sample size
✓ Published in peer-reviewed journal
✓ Clear, measurable outcomes
Limitations: ⚠️ Short duration (6 months only)
⚠️ Relatively small sample size
⚠️ Single-center study
⚠️ Doesn't assess cancer progression beyond PSA
⚠️ Long-term effects unknown

Follow-Up Research

MRI Correlation Study (Thomas et al., 2015)

Question: Does PSA stability correlate with actual disease stability?
Method:
  • Men on active surveillance
  • Some taking polyphenol supplements (including Pomi-T)
  • Some not taking supplements
  • Compared MRI findings with PSA changes
Results:
✅ Men on polyphenol supplements had more stable disease on MRI
✅ Stable PSA levels correlated with stable imaging
✅ Suggests PSA changes reflect real disease dynamics
Significance: PSA improvements likely reflect genuine disease stabilization, not just lab variation.

Broader Evidence on Dietary Supplements for Prostate Cancer

2020 Evidence Review (Grammatikopoulou et al., 2020)

Question: Do dietary supplements lower PSA in prostate cancer?
Findings:
  • Reviewed multiple RCTs on supplements
  • Pomegranate, green tea, saw palmetto, etc.
  • Most showed inadequate evidence for PSA reduction
  • Pomi-T stood out as having strong, positive evidence
Conclusion: While many supplements are studied, few have robust clinical trial support like Pomi-T.

Why Pomi-T is Different

Advantages over other supplements: ✓ Combination of 4 ingredients (synergistic)
✓ Rigorous clinical trial design
✓ Significant PSA benefit
✓ Well-tolerated
✓ Published in reputable journal

Pomi-T Dosage & Usage

Recommended Dosage

Standard dose:
  • 2 capsules daily with food
  • Taken for 6+ months
  • Consistent daily use
Timing:
  • Take with meals (improves absorption)
  • Morning or evening (consistent timing)
  • No specific time required

Duration

Short-term (6 months):
  • Shown to reduce PSA rise
  • Initial benefits observed
Long-term (12+ months):
  • Optimal duration unknown
  • Likely benefits continue
  • Requires ongoing monitoring

Who Should Consider Pomi-T?

✅ Good candidates:
  • Men with low-risk prostate cancer
  • On active surveillance
  • PSA <10 ng/mL
  • Seeking natural PSA support
  • Motivated for lifestyle interventions
❌ Not suitable for:
  • Advanced prostate cancer (needs conventional treatment)
  • Men not on active surveillance
  • Those unable to take supplements
  • Allergies to ingredients

Ingredients Breakdown

1. Pomegranate

Active compounds:
  • Ellagic acid
  • Punicalagins
  • Anthocyanins
Evidence:
  • Antioxidant properties
  • May slow PSA rise
  • Anti-inflammatory
  • Limited evidence alone

2. Green Tea

Active compounds:
  • EGCG (epigallocatechin gallate)
  • Catechins
  • Polyphenols
Evidence:
  • Strong antioxidant
  • Anti-cancer properties
  • May reduce cancer risk
  • Limited PSA reduction evidence alone

3. Broccoli

Active compounds:
  • Sulforaphane
  • Indoles
  • Glucosinolates
Evidence:
  • Detoxification support
  • Anti-cancer properties
  • May reduce cancer progression
  • Limited PSA evidence alone

4. Turmeric (Curcumin)

Active compounds:
  • Curcumin
  • Polyphenols
Evidence:
  • Potent anti-inflammatory
  • Antioxidant
  • May slow cancer growth
  • Limited PSA evidence alone
Note: Combination likely more effective than individual ingredients.

Side Effects & Safety

Common Side Effects

Frequency: <5% of users
  • Mild GI upset
  • Nausea (rare)
  • Diarrhea (rare)
  • Allergic reactions (very rare)

Precautions

⚠️ Allergies: Check ingredients if allergic to any component
⚠️ Medications: May interact with blood thinners (consult doctor)
⚠️ Pregnancy: Not studied; avoid if pregnant
⚠️ Breastfeeding: Unknown safety; consult doctor

Drug Interactions

Potential interactions:
  • Blood thinners (warfarin) - may enhance effect
  • Diabetes medications - may lower blood sugar
  • Blood pressure meds - may enhance effect
Action: Inform doctor if taking Pomi-T with other medications.

Pomi-T vs. Other Prostate Supplements

Comparison Table

Supplement Evidence PSA Benefit Cost/Month Quality
Pomi-T Strong (RCT) ✅ Proven $40-60 High
Pomegranate alone Moderate ? Limited $20-40 Variable
Green tea extract Moderate ? Limited $15-30 Variable
Saw palmetto Weak ❌ No $15-25 Variable
Lycopene Weak ? Limited $15-30 Variable

Key insight: Pomi-T has strongest evidence for PSA benefit.

Limitations & Future Research

Current Limitations

⚠️ Short-term data only (6 months studied)
⚠️ Small sample size (~100 per group)
⚠️ Single study (needs replication)
⚠️ PSA only (doesn't assess cancer progression directly)
⚠️ Active surveillance only (not tested in advanced cancer)
⚠️ Long-term safety unknown

Questions Needing Research

❓ Does benefit persist beyond 6 months?
❓ What's the optimal dose?
❓ Which ingredient is most important?
❓ Does it work for advanced cancer?
❓ Can it replace conventional treatment?
❓ Long-term safety profile?

Ongoing Studies

  • Extended follow-up of Pomi-T trial participants
  • Larger, multi-center trials planned
  • Mechanism of action studies
  • Combination with other therapies

Frequently Asked Questions

Does Pomi-T cure prostate cancer? No. It may slow PSA rise in low-risk disease on active surveillance. Not a cure or replacement for conventional treatment.
Can I take Pomi-T instead of treatment? Only if you're on active surveillance for low-risk cancer. Discuss with your oncologist. Not appropriate for advanced cancer.
How long until I see results? PSA benefits observed at 6 months in the trial. May take 3-6 months to notice changes.
Is Pomi-T covered by insurance? Usually not. Supplements are rarely covered. Check with your insurance.
Can I take Pomi-T with other supplements? Generally yes, but inform your doctor. Some combinations may have interactions.
What if PSA still rises on Pomi-T? Discuss with your doctor. May need conventional treatment. Pomi-T works for ~46% of men.
Is Pomi-T safe long-term? Unknown. Long-term safety not studied. Discuss duration with your doctor.
Can women take Pomi-T? Not designed for women. Ingredients are safe, but prostate-specific benefits don't apply.

Bottom Line

Pomi-T shows promise for slowing PSA progression in men with low-risk prostate cancer on active surveillance.
Key findings: ✅ 46% achieved PSA stability vs. 14% placebo
✅ 5x lower PSA rise with Pomi-T
✅ Well-tolerated with minimal side effects
✅ Strong clinical trial evidence
Important caveats: ⚠️ Short-term data only (6 months)
⚠️ Works for ~46% of men (not all)
⚠️ Not a replacement for conventional treatment
⚠️ Long-term effects unknown
⚠️ Only studied in active surveillance
Recommendation: Consider Pomi-T as adjunct therapy for low-risk prostate cancer on active surveillance. Discuss with your oncologist before starting.

Key Takeaways

  1. Pomi-T reduces PSA rise by 63% compared to placebo
  2. 46% achieve PSA stability with Pomi-T (vs. 14% placebo)
  3. Well-designed clinical trial supports efficacy
  4. Best for active surveillance of low-risk cancer
  5. Safe and well-tolerated with minimal side effects
  6. Cost-effective ($30-60/month)
  7. Long-term data needed for full assessment

References

Thomas, R., Williams, M., Sharma, H., Chaudry, A., & Bellamy, P. (2014). A double-blind, placebo-controlled randomised trial evaluating the effect of a polyphenol-rich whole food supplement on PSA progression in men with prostate cancer—the UK NCRN Pomi-T study. Prostate Cancer and Prostatic Diseases, 17, 180-186.

Grammatikopoulou, M., et al. (2020). Dietary Factors and Supplements Influencing PSA Concentrations. Nutrients, 12, 10298.

Thomas, R., Shaikh, M., Cauchi, M., & Yang, D. (2015). Prostate cancer progression defined by MRI correlates with serum PSA. Journal of Clinical Oncology, 1, 1-8.
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