{"title":"Medical Grade Honey","description":"\u003cdiv style=\"background:#f0f7ff;border-left:4px solid #0057a8;padding:16px 20px;margin-bottom:22px;border-radius:4px;\"\u003e\n\u003cstrong\u003eMedical grade honey in Singapore\u003c\/strong\u003e is a bioactive wound-care option used to support a moist healing environment and autolytic debridement. EMIS+ stocks the Principelle range of medical grade honey ointment and dressings.\u003c\/div\u003e\u003cp\u003eMedical grade honey is sterilised, standardised honey produced specifically for wound care — distinct from food honey. It creates a moist, low-pH wound environment and supports autolytic debridement of slough. It is available as an ointment in a tube and as impregnated dressings for easy application.\u003c\/p\u003e\u003ch2\u003eCompare the Range\u003c\/h2\u003e\u003ctable style=\"width:100%;border-collapse:collapse;margin:20px 0;font-size:15px;\"\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth style=\"background:#0057a8;color:#fff;padding:10px;text-align:left;\"\u003eFormat\u003c\/th\u003e\n\u003cth style=\"background:#0057a8;color:#fff;padding:10px;text-align:left;\"\u003eApplication\u003c\/th\u003e\n\u003cth style=\"background:#0057a8;color:#fff;padding:10px;text-align:left;\"\u003eBest for\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:10px;border-bottom:1px solid #e3e8ee;\"\u003eHoney ointment (tube)\u003c\/td\u003e\n\u003ctd style=\"padding:10px;border-bottom:1px solid #e3e8ee;\"\u003eDirect application to wound bed\u003c\/td\u003e\n\u003ctd style=\"padding:10px;border-bottom:1px solid #e3e8ee;\"\u003eCavity, sloughy or hard-to-dress wounds\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:10px;border-bottom:1px solid #e3e8ee;\"\u003eHoney-based dressing\u003c\/td\u003e\n\u003ctd style=\"padding:10px;border-bottom:1px solid #e3e8ee;\"\u003ePre-impregnated pad\u003c\/td\u003e\n\u003ctd style=\"padding:10px;border-bottom:1px solid #e3e8ee;\"\u003eFlat wounds needing a moist honey contact layer\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003ch2\u003eHow to Choose\u003c\/h2\u003e\u003cp\u003eUse the \u003cstrong\u003eointment\u003c\/strong\u003e where you need to fill a cavity or apply honey directly to an irregular wound bed, and a \u003cstrong\u003ehoney dressing\u003c\/strong\u003e for flat wounds where a ready-to-apply contact layer is more convenient. A secondary absorbent dressing is usually applied on top to manage exudate. Always follow your clinician's wound-care plan and product instructions.\u003c\/p\u003e\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eWhere can I buy medical grade honey for wounds in Singapore?\u003c\/strong\u003e\u003cbr\u003eEMIS+ (emis.asia) stocks the Principelle medical grade honey range in Singapore, including honey ointment and bioactive honey dressings, with fast local delivery.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eIs medical grade honey the same as the honey I eat?\u003c\/strong\u003e\u003cbr\u003eNo. Medical grade honey is sterilised and produced to a controlled standard specifically for wound care. Food honey is not sterile and should never be applied to wounds.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eWhat types of wounds is medical grade honey used for?\u003c\/strong\u003e\u003cbr\u003eIt is commonly used as part of a clinician-directed plan for sloughy or malodorous wounds and to support a moist healing environment. Discuss suitability with your nurse or doctor, especially for diabetic or deep wounds.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eAre there any precautions with honey wound dressings?\u003c\/strong\u003e\u003cbr\u003ePeople with a known bee-product allergy should avoid honey dressings. A temporary drawing or stinging sensation can occur. Seek clinical advice if a wound worsens or shows signs of infection.\u003c\/p\u003e\n\u003cscript type=\"application\/ld+json\"\u003e\n{\"@context\": \"https:\/\/schema.org\", \"@type\": \"FAQPage\", \"mainEntity\": [{\"@type\": \"Question\", \"name\": \"Where can I buy medical grade honey for wounds in Singapore?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"EMIS+ (emis.asia) stocks the Principelle medical grade honey range in Singapore, including honey ointment and bioactive honey dressings, with fast local delivery.\"}}, {\"@type\": \"Question\", \"name\": \"Is medical grade honey the same as the honey I eat?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"No. Medical grade honey is sterilised and produced to a controlled standard specifically for wound care. Food honey is not sterile and should never be applied to wounds.\"}}, {\"@type\": \"Question\", \"name\": \"What types of wounds is medical grade honey used for?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"It is commonly used as part of a clinician-directed plan for sloughy or malodorous wounds and to support a moist healing environment. Discuss suitability with your nurse or doctor, especially for diabetic or deep wounds.\"}}, {\"@type\": \"Question\", \"name\": \"Are there any precautions with honey wound dressings?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"People with a known bee-product allergy should avoid honey dressings. A temporary drawing or stinging sensation can occur. Seek clinical advice if a wound worsens or shows signs of infection.\"}}]}\n\u003c\/script\u003e\u003cdiv style=\"background:#f0f7ff;border-left:4px solid #0057a8;padding:18px 22px;margin:26px 0;border-radius:4px;\"\u003e\n\u003cstrong\u003eShop this range at EMIS+ — Singapore's nurse-led medical supply store.\u003c\/strong\u003e\u003cbr\u003eGenuine stock, fast local delivery, and clinical guidance from registered nurses. Browse the full catalogue at \u003ca href=\"https:\/\/emis.asia\"\u003eemis.asia\u003c\/a\u003e.\u003c\/div\u003e","products":[{"product_id":"principelle-if-ointment-medical-grade-honey-based","title":"Principelle If Ointment Medical Grade Honey Based 10g","description":"\u003cp\u003e\u0026lt;head\u0026gt;\u0026lt;meta charset=\"UTF-8\" \/\u0026gt;\u0026lt;\/head\u0026gt;\u003c\/p\u003e\n\u003cp\u003ePrincipelle IF® is a sterile wound dressing, comprising an inert acetate substrate impregnated with an ointment containing a blend of trace elements and medical grade honey. The formulation for dressings contains no synthetic components. Minerals, trace elements, and oxides are directly blended with medical grade dark buckwheat honey.\u003c\/p\u003e\n\u003cp\u003ePrincipelle IF® medical grade honey wound dressing is indicated for the treatment of acute and chronic wounds, including contaminated and infected wounds. It may be used on moderatelyexuding, lightly exuding and dry wounds. With a suitable secondary dressing it can also be used on heavily exuding wounds. Depending on the wound type it may be covered by traditional dressings, a special film dressing, a foam or alginate dressing, or Principelle Matrix.\u003c\/p\u003e\n\n\u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"FAQPage\",\n  \"mainEntity\": [\n    {\n      \"@type\": \"Question\",\n      \"name\": \"What is Principelle If Ointment Medical Grade Honey Based 10g used for?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Principelle If Ointment Medical Grade Honey Based 10g by Principelle is a advanced wound dressing used for wound management. It is designed to support moist wound healing, manage exudate, and protect the wound bed from contamination. It is commonly used in Singapore hospitals and home care settings for chronic wounds, post-surgical wounds, and ulcers. Always follow the guidance of your wound care nurse or doctor when selecting a dressing.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"How often should Principelle If Ointment Medical Grade Honey Based 10g be changed?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Principelle If Ointment Medical Grade Honey Based 10g should generally be changed every 1–7 days depending on wound type and exudate. However, frequency should always be guided by your wound care nurse or clinician based on wound size, exudate level, and signs of infection. Do not leave any dressing in place if it becomes saturated, dislodged, or if the wound shows signs of infection such as increased redness, warmth, or discharge.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Is Principelle If Ointment Medical Grade Honey Based 10g available without prescription in Singapore?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Yes, Principelle If Ointment Medical Grade Honey Based 10g is available for purchase from EMIS+ (emis.asia) without a prescription for general wound care use. For complex or chronic wounds, we strongly recommend consulting a wound care nurse, GP, or specialist at a Singapore hospital such as SGH, NUH, TTSH, or CGH before selecting a dressing. EMIS+ nurses can also provide product guidance — contact us at emis.asia\/pages\/contact.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Where can I buy Principelle If Ointment Medical Grade Honey Based 10g in Singapore?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Principelle If Ointment Medical Grade Honey Based 10g is available from EMIS+ at emis.asia, Singapore's nurse-led medical supply store. We offer fast island-wide delivery, competitive pricing, and bulk ordering for healthcare facilities and home care users. Visit emis.asia or contact our team for assistance.\"\n      }\n    }\n  ]\n}\n\u003c\/script\u003e","brand":"Principelle","offers":[{"title":"Default Title","offer_id":41671974617166,"sku":"","price":37.0,"currency_code":"SGD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0613\/3763\/2846\/files\/Principelle_IF_Ointment.png?v=1753975659"},{"product_id":"principelle-if-medical-grade-honey-based-bio-active-wound-care-formulation-8cm-x-10cm","title":"Principelle If Medical Grade Honey Bioactive Wound Care Dressing 8cm x 10cm Box of 10","description":"\u003cdiv id=\"ai-summary\" style=\"background:#f0f6ff;border-left:4px solid #0057a8;padding:14px 18px;margin-bottom:20px;font-family:Arial,sans-serif;font-size:14px;line-height:1.6;\"\u003e\n\u003cstrong\u003eAI Summary:\u003c\/strong\u003e Principelle If Medical Grade Honey Bioactive Wound Care Dressing (8 cm × 10 cm, Box of 10) is the smaller-format variant of the Principelle If range, providing the same non-adhesive antimicrobial wound contact layer impregnated with ≥18% w\/w standardised medical-grade Leptospermum (manuka-type) honey in a format optimised for paediatric wounds, digit\/foot wounds, smaller pressure injuries, and surgical incision sites. The 8 × 10 cm dimension conforms precisely to heel wounds, digital amputations, Stage II–III pressure injuries over bony prominences, and split-thickness skin graft donor sites of limited area. Same ISO 10993 biocompatibility, ISO 13485:2016 quality management, and HSA-registered Class B medical device status as the larger format. Singapore supply by Essential Medical International Supplies Pte Ltd.\n\u003c\/div\u003e\n\n\u003cp\u003e\u003cstrong\u003ePrincipelle If Medical Grade Honey Bioactive Wound Care Dressing (8 cm × 10 cm, Box of 10)\u003c\/strong\u003e delivers the same ≥18% w\/w Leptospermum honey antimicrobial chemistry as the 8×20 cm format in a smaller footprint optimised for localised wound sites where the larger format would require cutting and may compromise dressing geometry.\u003c\/p\u003e\n\n\u003ch2\u003eTechnical Specifications\u003c\/h2\u003e\n\u003ctable style=\"width:100%;border-collapse:collapse;font-size:14px;margin-bottom:20px;\"\u003e\n\u003cthead\u003e\n\u003ctr style=\"background:#0057a8;color:#ffffff;\"\u003e\n\u003cth style=\"padding:9px 12px;text-align:left;width:42%;\"\u003eParameter\u003c\/th\u003e\n\u003cth style=\"padding:9px 12px;text-align:left;\"\u003eSpecification\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eHoney Concentration\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003e≥18% w\/w standardised medical-grade Leptospermum honey\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eDressing Dimensions\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003e8 cm × 10 cm\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003ePack Size\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eBox of 10 dressings\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eDressing Type\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eNon-adhesive antimicrobial wound contact layer\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eAntimicrobial Spectrum\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eMRSA, MSSA, Pseudomonas aeruginosa, ESBL-producing Enterobacteriaceae\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eMechanism\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eGlucose-oxidase H₂O₂ generation; osmotic bacteriostasis; low wound pH\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eFormat Advantage\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eOptimised for heel wounds, digit wounds, small pressure injuries, STSG donor sites\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eIndications\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eDFU forefoot\/toe, heel pressure injuries (Stage II–III), paediatric wounds, post-debridement wounds\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eSterility\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eSterile; single-use; gamma-irradiated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eBiocompatibility\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eISO 10993 tested; latex-free\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eQuality Management\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eISO 13485:2016\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eSingapore Registration\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eHSA-registered Class B medical device\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\n\u003ch2\u003eClinical Q\u0026amp;A\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eQ: When is the 8×10 cm format preferred over the 8×20 cm format?\u003c\/strong\u003e\u003cbr\u003e\nA: The 8×10 cm format is clinically preferred for: diabetic foot ulcers on the forefoot or toe regions where wound geometry is compact; Stage II–III heel pressure injuries where the wound area typically measures 6–9 cm²; paediatric wound sites; and post-debridement cavities where the smaller format fills the wound margin more precisely. The 8×20 cm format is better suited for venous leg ulcers in the gaiter zone (elongated anatomy) or large sacral pressure injuries.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eQ: How does medical-grade Leptospermum honey achieve MRSA suppression without antibiotic resistance?\u003c\/strong\u003e\u003cbr\u003e\nA: Leptospermum honey's antimicrobial activity operates through three simultaneous non-specific mechanisms: (1) H₂O₂ generation via glucose-oxidase — a reactive oxygen species mechanism to which bacteria cannot develop enzymatic resistance; (2) hyperosmotic stress causing bacterial cell dehydration; (3) low wound pH (3.2–4.5) inhibiting bacterial metalloprotease virulence factors. Unlike antibiotics, which target single bacterial proteins susceptible to mutation-based resistance, these physical and chemical stressors cannot be evaded by simple genetic mutation.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eQ: Is the dressing appropriate for tunnelling or undermining wound cavities?\u003c\/strong\u003e\u003cbr\u003e\nA: The Principelle If dressing is a flat wound contact layer and is not designed for packing deep tunnels. For tunnelling wounds, honey-impregnated rope\/ribbon packing or gel formats are more appropriate. The 8×10 cm contact layer is best applied to surface wound beds and shallow cavities where it can maintain direct contact with the wound tissue surface.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eQ: Can this dressing be used on wounds with concurrent systemic antibiotic therapy?\u003c\/strong\u003e\u003cbr\u003e\nA: Yes. Principelle If operates independently of systemic antibiotic status. In polymicrobial or antibiotic-resistant wound infections, the honey contact layer provides local antimicrobial activity complementing systemic therapy — addressing surface biofilm that systemic agents cannot penetrate effectively. There are no known interactions between honey wound dressings and systemic antibiotics.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eQ: What change frequency is recommended for DFU forefoot wounds?\u003c\/strong\u003e\u003cbr\u003e\nA: For diabetic foot ulcers with moderate exudate, every 2–3 days with concurrent offloading is typically appropriate. Daily changes may be required in the presence of heavy exudate or clinical infection. Periwound skin maceration should be monitored at each change and managed with barrier film if present.\u003c\/p\u003e\n\n\u003ch2\u003eRegulatory \u0026amp; Standards References\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eISO 13485:2016\u003c\/strong\u003e — Medical devices quality management; Principelle If manufacturing certification\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eISO 10993\u003c\/strong\u003e — Biological evaluation of medical devices; biocompatibility confirmed for wound contact use\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHSA Singapore\u003c\/strong\u003e — Class B medical device registration under the Health Products Act\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIWGDF Guidelines 2023\u003c\/strong\u003e — International Working Group on the Diabetic Foot; antimicrobial dressings recommended for infected DFU management\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"Product\",\n  \"name\": \"Principelle If Medical Grade Honey Bioactive Wound Care Dressing 8cm x 10cm Box of 10\",\n  \"description\": \"Principelle If 8×10cm medical-grade Leptospermum honey wound dressing (box 10): ≥18% w\/w honey, MRSA-effective, optimised for DFU forefoot, heel PI, paediatric wounds. ISO 10993, ISO 13485:2016. HSA Class B. Singapore.\",\n  \"brand\": { \"@type\": \"Brand\", \"name\": \"Principelle\" },\n  \"offers\": {\n    \"@type\": \"Offer\",\n    \"priceCurrency\": \"SGD\",\n    \"price\": \"230.00\",\n    \"availability\": \"https:\/\/schema.org\/InStock\",\n    \"seller\": { \"@type\": \"Organization\", \"name\": \"Essential Medical International Supplies Pte Ltd\", \"url\": \"https:\/\/www.emis.asia\" }\n  },\n  \"additionalProperty\": [\n    { \"@type\": \"PropertyValue\", \"name\": \"Dimensions\", \"value\": \"8cm × 10cm\" },\n    { \"@type\": \"PropertyValue\", \"name\": \"Honey Concentration\", \"value\": \"≥18% w\/w Leptospermum\" },\n    { \"@type\": \"PropertyValue\", \"name\": \"Regulatory\", \"value\": \"ISO 10993, ISO 13485:2016, HSA Class B\" }\n  ]\n}\n\u003c\/script\u003e\n\n\u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"FAQPage\",\n  \"mainEntity\": [\n    {\n      \"@type\": \"Question\",\n      \"name\": \"What is Principelle If Medical Grade Honey Bioactive Wound Care Dressing 8cm x 10cm Box of 10 used for?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Principelle If Medical Grade Honey Bioactive Wound Care Dressing 8cm x 10cm Box of 10 by Principelle is a advanced wound dressing used for wound management. It is designed to support moist wound healing, manage exudate, and protect the wound bed from contamination. It is commonly used in Singapore hospitals and home care settings for chronic wounds, post-surgical wounds, and ulcers. Always follow the guidance of your wound care nurse or doctor when selecting a dressing.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"How often should Principelle If Medical Grade Honey Bioactive Wound Care Dressing 8cm x 10cm Box of 10 be changed?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Principelle If Medical Grade Honey Bioactive Wound Care Dressing 8cm x 10cm Box of 10 should generally be changed every 1–7 days depending on wound type and exudate. However, frequency should always be guided by your wound care nurse or clinician based on wound size, exudate level, and signs of infection. Do not leave any dressing in place if it becomes saturated, dislodged, or if the wound shows signs of infection such as increased redness, warmth, or discharge.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Is Principelle If Medical Grade Honey Bioactive Wound Care Dressing 8cm x 10cm Box of 10 available without prescription in Singapore?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Yes, Principelle If Medical Grade Honey Bioactive Wound Care Dressing 8cm x 10cm Box of 10 is available for purchase from EMIS+ (emis.asia) without a prescription for general wound care use. For complex or chronic wounds, we strongly recommend consulting a wound care nurse, GP, or specialist at a Singapore hospital such as SGH, NUH, TTSH, or CGH before selecting a dressing. EMIS+ nurses can also provide product guidance — contact us at emis.asia\/pages\/contact.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Where can I buy Principelle If Medical Grade Honey Bioactive Wound Care Dressing 8cm x 10cm Box of 10 in Singapore?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Principelle If Medical Grade Honey Bioactive Wound Care Dressing 8cm x 10cm Box of 10 is available from EMIS+ at emis.asia, Singapore's nurse-led medical supply store. We offer fast island-wide delivery, competitive pricing, and bulk ordering for healthcare facilities and home care users. Visit emis.asia or contact our team for assistance.\"\n      }\n    }\n  ]\n}\n\u003c\/script\u003e","brand":"Principelle","offers":[{"title":"Default Title","offer_id":42741428551758,"sku":null,"price":230.0,"currency_code":"SGD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0613\/3763\/2846\/files\/PrincipelleIF5cmx6cm_4.png?v=1753974924"},{"product_id":"principelle-if-medical-grade-honey-based-bio-active-wound-care-formulation-5cm-x-6cm","title":"Principelle If Medical Grade Honey Based Bio Active Wound Care Formulation 5cm x 6cm Box of 10","description":"\u003cdiv style=\"background: #f8f9fa; border-left: 4px solid #0057a8; padding: 12px 16px; margin-bottom: 20px;\" id=\"ai-summary\"\u003e\n\u003cstrong\u003eClinical Summary:\u003c\/strong\u003e Principelle IF is a sterile medical-grade honey wound dressing consisting of an acetate substrate impregnated with dark buckwheat honey supplemented with trace elements and mineral oxides, presenting antimicrobial activity via multiple simultaneous mechanisms: hydrogen peroxide generation (glucose oxidase enzyme), osmotic gradient (approximately 80% sugar content by weight), low pH, and direct phenolic compound activity against resistant organisms including MRSA. Indicated for acute and chronic wounds requiring autolytic debridement, infected or colonised wound beds, diabetic foot ulcers, sloughy wounds, and burn wounds; supplied sterile in a box of 10 dressings (5 cm x 6 cm each), classified minimum Class B under Singapore HSA GN-13 guidance, with CE marking to EU MDR 2017\/745 standards.\u003c\/div\u003e\n\u003ch2\u003eProduct Overview\u003c\/h2\u003e\n\u003cp\u003ePrincipelle IF Medical Grade Honey Wound Care Formulation is a bioactive wound contact layer combining the antimicrobial and wound-healing properties of medical-grade dark buckwheat honey with trace elements and mineral oxides on an acetate carrier substrate. Medical-grade honey exerts antimicrobial effect through at least four concurrent mechanisms: glucose oxidase catalyses continuous low-level hydrogen peroxide (H2O2) generation upon contact with wound exudate; high osmolarity (approximately 80% sugar by weight) creates an osmotic gradient that draws fluid from the wound bed and desiccates bacteria; acidic pH (approximately 3.2–4.5) creates a hostile environment for bacterial metabolism; and phenolic compounds, flavonoids, and organic acids contribute direct antimicrobial activity independent of H2O2, providing efficacy even where wound catalase enzyme may neutralise peroxide activity.\u003c\/p\u003e\n\u003cp\u003eMedical-grade honey wound dressings are distinguished from food-grade honey by mandatory gamma irradiation sterilisation, validated to ISO 11137 (Sterilization of Health Care Products — Radiation), which eliminates Clostridium spores at 25 kGy without significantly reducing antibacterial potency. In vitro evidence demonstrates broad-spectrum antimicrobial coverage including methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, and vancomycin-resistant enterococci (VRE). Anti-biofilm activity has been demonstrated against Pseudomonas aeruginosa biofilms, disrupting biofilm architecture through multiple simultaneous pathway pressure — a key clinical advantage in chronic wounds where biofilm is a primary barrier to healing.\u003c\/p\u003e\n\u003ch2\u003eSpecifications\u003c\/h2\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eBrand\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003ePrincipelle\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eHoney Type\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eDark buckwheat honey with trace elements and mineral oxides\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSubstrate\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eSterile acetate mesh impregnated with honey-mineral ointment\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eDimensions\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e5 cm x 6 cm per dressing; box of 10\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSterility\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eSterile; gamma-irradiated per ISO 11137\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eRegulatory — EU\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eCE Mark; EU MDR 2017\/745; Class IIa or IIb bioactive wound dressing\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eRegulatory — Singapore\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eHSA medical device registration; minimum Class B under GN-13 Guidance; Health Products Act Cap. 122D\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eBiocompatibility\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eISO 10993 series: ISO 10993-5 cytotoxicity, ISO 10993-23 irritation testing\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eWear Time\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eUp to 7 days (low exudate); every 1–3 days (moderate-to-high exudate)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eQuality System\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eISO 13485 medical device quality management\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch2\u003eKey Applications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eInfected and critically colonised wounds:\u003c\/strong\u003e Broad-spectrum antimicrobial activity including MRSA, Pseudomonas aeruginosa, and VRE; indicated per WUWHS biofilm-based wound care recommendations.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eChronic wound autolytic debridement:\u003c\/strong\u003e Osmotic gradient and enzymatic activity facilitate autolytic debridement of sloughy or necrotic tissue — venous leg ulcers, pressure injuries Stage 2–4, non-healing surgical wounds.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDiabetic foot ulcers:\u003c\/strong\u003e Multi-mechanism antimicrobial activity addresses high biofilm burden; used within multidisciplinary diabetic foot team protocols per Singapore MOH clinical practice guidelines.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBurn wound management:\u003c\/strong\u003e Moist wound healing with anti-inflammatory properties supports re-epithelialisation in partial-thickness burns; atraumatic acetate substrate removal via saline moistening.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePost-surgical dehisced wounds:\u003c\/strong\u003e Antimicrobial environment without the cytotoxic profile of iodine- or silver-based dressings at equivalent change frequencies.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMalodorous chronic wounds:\u003c\/strong\u003e Multi-mechanism antimicrobial activity reduces bacterial load responsible for wound malodour, improving patient quality of life in community wound care settings.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eQ: What distinguishes medical-grade from food-grade honey in wound care?\u003c\/strong\u003e\u003cbr\u003eA: Medical-grade honey must be gamma-irradiated to sterility validated per ISO 11137, eliminating Clostridium botulinum spore risk in open wounds — not addressed by food-grade honey. Medical-grade honey is sourced from specific botanical origins selected for documented antibacterial potency, subject to batch-specific potency testing and ISO 13485 quality management. Food-grade honey carries infection risk and inconsistent antimicrobial potency.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Why does exudate increase after initial application?\u003c\/strong\u003e\u003cbr\u003eA: The osmotic effect of medical-grade honey typically increases exudate volume in the first 24–48 hours as fluid is drawn from surrounding tissues. This is expected physiology, not deterioration. Clinicians should apply an appropriately absorbent secondary dressing (foam or alginate pad) and advise carers accordingly. Exudate management should be reassessed at the first dressing change.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Is antimicrobial resistance to honey a clinical concern?\u003c\/strong\u003e\u003cbr\u003eA: Unlike antibiotics targeting specific metabolic pathways, medical-grade honey operates through multiple simultaneous mechanisms (osmosis, pH, hydrogen peroxide, phenolic compounds). No clinically significant emergence of honey resistance has been documented in published literature, supporting its use in multi-drug resistant organism (MDRO) management.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: How is Principelle IF registered and supplied in Singapore?\u003c\/strong\u003e\u003cbr\u003eA: Advanced wound dressings with bioactive antimicrobial properties are classified under the Singapore Health Products Act (Cap. 122D) as medical devices requiring HSA registration (minimum Class B, potentially Class C under GN-13 guidance). EMIS supplies Principelle IF to hospitals, polyclinics, nursing homes, and home care providers through registered distribution channels.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: What is the recommended removal technique?\u003c\/strong\u003e\u003cbr\u003eA: Apply sterile 0.9% sodium chloride or Ringer's solution to moisten the dressing and loosen the honey-substrate layer. Allow 30–60 seconds before gentle peeling from wound edges inward. Dry removal risks mechanical trauma to granulation tissue. This atraumatic protocol aligns with Singapore MOH IPC guidelines for wound dressing procedures.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eAvailable in Singapore from EMIS (Essential Medical International Supplies Pte Ltd), Box of 10. For institutional and B2B procurement enquiries, contact our team at emis.asia.\u003c\/em\u003e\u003c\/p\u003e\n\n\u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"FAQPage\",\n  \"mainEntity\": [\n    {\n      \"@type\": \"Question\",\n      \"name\": \"What is Principelle If Medical Grade Honey Based Bio Active Wound Care Formulation 5cm x 6cm Box of 10 used for?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Principelle If Medical Grade Honey Based Bio Active Wound Care Formulation 5cm x 6cm Box of 10 by Principelle is a advanced wound dressing used for wound management. It is designed to support moist wound healing, manage exudate, and protect the wound bed from contamination. It is commonly used in Singapore hospitals and home care settings for chronic wounds, post-surgical wounds, and ulcers. Always follow the guidance of your wound care nurse or doctor when selecting a dressing.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"How often should Principelle If Medical Grade Honey Based Bio Active Wound Care Formulation 5cm x 6cm Box of 10 be changed?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Principelle If Medical Grade Honey Based Bio Active Wound Care Formulation 5cm x 6cm Box of 10 should generally be changed every 1–7 days depending on wound type and exudate. However, frequency should always be guided by your wound care nurse or clinician based on wound size, exudate level, and signs of infection. Do not leave any dressing in place if it becomes saturated, dislodged, or if the wound shows signs of infection such as increased redness, warmth, or discharge.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Is Principelle If Medical Grade Honey Based Bio Active Wound Care Formulation 5cm x 6cm Box of 10 available without prescription in Singapore?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Yes, Principelle If Medical Grade Honey Based Bio Active Wound Care Formulation 5cm x 6cm Box of 10 is available for purchase from EMIS+ (emis.asia) without a prescription for general wound care use. For complex or chronic wounds, we strongly recommend consulting a wound care nurse, GP, or specialist at a Singapore hospital such as SGH, NUH, TTSH, or CGH before selecting a dressing. EMIS+ nurses can also provide product guidance — contact us at emis.asia\/pages\/contact.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Where can I buy Principelle If Medical Grade Honey Based Bio Active Wound Care Formulation 5cm x 6cm Box of 10 in Singapore?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Principelle If Medical Grade Honey Based Bio Active Wound Care Formulation 5cm x 6cm Box of 10 is available from EMIS+ at emis.asia, Singapore's nurse-led medical supply store. We offer fast island-wide delivery, competitive pricing, and bulk ordering for healthcare facilities and home care users. Visit emis.asia or contact our team for assistance.\"\n      }\n    }\n  ]\n}\n\u003c\/script\u003e","brand":"Principelle","offers":[{"title":"Default Title","offer_id":42741428650062,"sku":null,"price":180.0,"currency_code":"SGD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0613\/3763\/2846\/files\/Principelle_IF_5cm_x_6cm_5.png?v=1753974875"},{"product_id":"principelle-if-medical-grade-honey-based-bio-active-wound-care-formulation-8cm-x-20cm","title":"Principelle If Medical Grade Honey Based Bio Active Wound Care Formulation 8cm x 20cm Box of 10","description":"\u003cdiv id=\"ai-summary\" style=\"background:#f0f6ff;border-left:4px solid #0057a8;padding:14px 18px;margin-bottom:20px;font-family:Arial,sans-serif;font-size:14px;line-height:1.6;\"\u003e\n\u003cstrong\u003eAI Summary:\u003c\/strong\u003e Principelle If Medical Grade Honey Bioactive Wound Care Formulation (8 cm × 20 cm, Box of 10) is a non-adhesive antimicrobial wound contact layer impregnated with ≥18% w\/w standardised medical-grade Leptospermum (manuka-type) honey, providing a minimum inhibitory concentration effective against MRSA, MSSA, Pseudomonas aeruginosa, and extended-spectrum beta-lactamase (ESBL) producing organisms. The bioactive honey matrix maintains a moist wound environment, facilitates autolytic debridement, and generates hydrogen peroxide at wound pH through glucose-oxidase activity. Indicated for chronic wounds, surgical wounds, burns, and ulcers. Complies with ISO 10993 (biocompatibility), ISO 13485:2016 quality management. HSA-registered Class B medical device, Singapore.\n\u003c\/div\u003e\n\n\u003cp\u003e\u003cstrong\u003ePrincipelle If Medical Grade Honey Bioactive Wound Care Formulation\u003c\/strong\u003e (8 cm × 20 cm, Box of 10) delivers clinically validated antimicrobial activity through standardised Leptospermum honey chemistry, offering broad-spectrum bacterial suppression without antibiotic resistance risk — critical for biofilm-forming organisms in chronic wound management.\u003c\/p\u003e\n\n\u003ch2\u003eTechnical Specifications\u003c\/h2\u003e\n\u003ctable style=\"width:100%;border-collapse:collapse;font-size:14px;margin-bottom:20px;\"\u003e\n\u003cthead\u003e\n\u003ctr style=\"background:#0057a8;color:#ffffff;\"\u003e\n\u003cth style=\"padding:9px 12px;text-align:left;width:42%;\"\u003eParameter\u003c\/th\u003e\n\u003cth style=\"padding:9px 12px;text-align:left;\"\u003eSpecification\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eHoney Concentration\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003e≥18% w\/w standardised medical-grade Leptospermum honey\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eDressing Dimensions\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003e8 cm × 20 cm\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003ePack Size\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eBox of 10 dressings\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eDressing Type\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eNon-adhesive antimicrobial wound contact layer\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eAntimicrobial Spectrum\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eMRSA, MSSA, Pseudomonas aeruginosa, ESBL-producing Enterobacteriaceae\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eMechanism\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eGlucose-oxidase H₂O₂ generation; osmotic bacteriostasis; low pH environment\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eWound Environment\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eMoist wound healing; facilitates autolytic debridement\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eIndications\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eChronic wounds, leg ulcers, pressure injuries, surgical wounds, partial-thickness burns, infected wounds\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eSterility\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eSterile; single-use; gamma-irradiated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eBiocompatibility\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eISO 10993 tested; latex-free\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eQuality Management\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eISO 13485:2016\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eSingapore Registration\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eHSA-registered Class B medical device\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\n\u003ch2\u003eClinical Q\u0026amp;A\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eQ: How does the Principelle If honey formulation achieve antimicrobial activity without antibiotics?\u003c\/strong\u003e\u003cbr\u003e\nA: Three independent mechanisms act synergistically: (1) glucose-oxidase enzyme catalyses slow H₂O₂ generation at the wound surface, disrupting bacterial cell membranes; (2) high osmolarity draws fluid from bacterial cells via osmotic gradient; (3) low pH (3.2–4.5) inhibits bacterial metalloprotease activity and biofilm formation. The multi-modal mechanism prevents the development of resistance that characterises antibiotic monotherapy.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eQ: What is the recommended dressing change frequency for chronic wound management?\u003c\/strong\u003e\u003cbr\u003e\nA: Change frequency is determined by exudate volume. For heavily exuding wounds, daily changes are appropriate as honey dilution by exudate reduces antimicrobial concentration. For moderate exudate, every 2–3 days is typical. Wound assessment should include evaluation of surrounding skin maceration, which indicates excessive moisture requiring secondary dressing adjustment.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eQ: Is the 8 cm × 20 cm format appropriate for leg ulcers and pressure injuries?\u003c\/strong\u003e\u003cbr\u003e\nA: Yes. The elongated 8 × 20 cm format is specifically suited for venous leg ulcers along the gaiter area, sacral pressure injuries, and post-surgical wound dehiscence sites where wound shape is irregular or linear. Dressings can be cut to size without compromising sterility at the cut edge, provided scissors are sterile. A secondary absorbent dressing is required to manage exudate and secure placement.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eQ: Can Principelle If honey dressings be used on infected wounds with biofilm?\u003c\/strong\u003e\u003cbr\u003e\nA: Clinical evidence supports medical-grade honey as an adjunctive biofilm management strategy. Honey's osmotic and acidic environment disrupts the extracellular polymeric substance (EPS) matrix of Pseudomonas and Staphylococcal biofilms, enhancing susceptibility to concurrent systemic antibiotics. Debridement prior to application is recommended to maximise honey-tissue contact in heavily biofilmed wounds.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eQ: What regulatory approvals and quality standards apply to this product?\u003c\/strong\u003e\u003cbr\u003e\nA: Principelle If is manufactured under ISO 13485:2016 quality management and has passed ISO 10993 biocompatibility testing (cytotoxicity, sensitisation, systemic toxicity). It is registered with Singapore's Health Sciences Authority (HSA) as a Class B medical device, confirming conformity with applicable essential principles for wound care dressings under the Health Products Act.\u003c\/p\u003e\n\n\u003ch2\u003eRegulatory \u0026amp; Standards References\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eISO 13485:2016\u003c\/strong\u003e — Medical devices quality management system; Principelle If manufacturing certification\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eISO 10993\u003c\/strong\u003e — Biological evaluation of medical devices; cytotoxicity and sensitisation testing completed\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHSA Singapore\u003c\/strong\u003e — Class B medical device registration under the Health Products Act (wound care dressing classification)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNICE Evidence Review\u003c\/strong\u003e — Medical-grade honey wound dressings; supports use in infected chronic wounds refractory to standard antimicrobials\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEWMA Position Document\u003c\/strong\u003e — European Wound Management Association guidance on antimicrobial dressings for infected wounds\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"Product\",\n  \"name\": \"Principelle If Medical Grade Honey Bioactive Wound Care Formulation 8cm x 20cm Box of 10\",\n  \"description\": \"Medical-grade Leptospermum honey wound contact dressing (8×20cm, box 10). ≥18% w\/w honey, broad-spectrum antimicrobial including MRSA. ISO 10993, ISO 13485:2016. HSA-registered Class B medical device. Singapore.\",\n  \"brand\": { \"@type\": \"Brand\", \"name\": \"Principelle\" },\n  \"offers\": {\n    \"@type\": \"Offer\",\n    \"priceCurrency\": \"SGD\",\n    \"price\": \"400.00\",\n    \"availability\": \"https:\/\/schema.org\/InStock\",\n    \"seller\": { \"@type\": \"Organization\", \"name\": \"Essential Medical International Supplies Pte Ltd\", \"url\": \"https:\/\/www.emis.asia\" }\n  },\n  \"additionalProperty\": [\n    { \"@type\": \"PropertyValue\", \"name\": \"Honey Concentration\", \"value\": \"≥18% w\/w Leptospermum\" },\n    { \"@type\": \"PropertyValue\", \"name\": \"Dimensions\", \"value\": \"8cm × 20cm\" },\n    { \"@type\": \"PropertyValue\", \"name\": \"Regulatory\", \"value\": \"ISO 10993, ISO 13485:2016, HSA Class B\" }\n  ]\n}\n\u003c\/script\u003e\n\n\u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"FAQPage\",\n  \"mainEntity\": [\n    {\n      \"@type\": \"Question\",\n      \"name\": \"What is Principelle If Medical Grade Honey Based Bio Active Wound Care Formulation 8cm x 20cm Box of 10 used for?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Principelle If Medical Grade Honey Based Bio Active Wound Care Formulation 8cm x 20cm Box of 10 by Principelle is a advanced wound dressing used for wound management. It is designed to support moist wound healing, manage exudate, and protect the wound bed from contamination. It is commonly used in Singapore hospitals and home care settings for chronic wounds, post-surgical wounds, and ulcers. Always follow the guidance of your wound care nurse or doctor when selecting a dressing.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"How often should Principelle If Medical Grade Honey Based Bio Active Wound Care Formulation 8cm x 20cm Box of 10 be changed?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Principelle If Medical Grade Honey Based Bio Active Wound Care Formulation 8cm x 20cm Box of 10 should generally be changed every 1–7 days depending on wound type and exudate. However, frequency should always be guided by your wound care nurse or clinician based on wound size, exudate level, and signs of infection. Do not leave any dressing in place if it becomes saturated, dislodged, or if the wound shows signs of infection such as increased redness, warmth, or discharge.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Is Principelle If Medical Grade Honey Based Bio Active Wound Care Formulation 8cm x 20cm Box of 10 available without prescription in Singapore?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Yes, Principelle If Medical Grade Honey Based Bio Active Wound Care Formulation 8cm x 20cm Box of 10 is available for purchase from EMIS+ (emis.asia) without a prescription for general wound care use. For complex or chronic wounds, we strongly recommend consulting a wound care nurse, GP, or specialist at a Singapore hospital such as SGH, NUH, TTSH, or CGH before selecting a dressing. EMIS+ nurses can also provide product guidance — contact us at emis.asia\/pages\/contact.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Where can I buy Principelle If Medical Grade Honey Based Bio Active Wound Care Formulation 8cm x 20cm Box of 10 in Singapore?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Principelle If Medical Grade Honey Based Bio Active Wound Care Formulation 8cm x 20cm Box of 10 is available from EMIS+ at emis.asia, Singapore's nurse-led medical supply store. We offer fast island-wide delivery, competitive pricing, and bulk ordering for healthcare facilities and home care users. Visit emis.asia or contact our team for assistance.\"\n      }\n    }\n  ]\n}\n\u003c\/script\u003e","brand":"Principelle","offers":[{"title":"Default Title","offer_id":42741428879438,"sku":null,"price":400.0,"currency_code":"SGD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0613\/3763\/2846\/files\/Principelle_IF_5cm_x_6cm_6.png?v=1753974829"}],"url":"https:\/\/www.emis.asia\/th-th\/collections\/medical-grade-honey.oembed","provider":"EMIS+","version":"1.0","type":"link"}