{"product_id":"nuchido-time-30-day-supply","title":"Nuchido TIME+ NAD Supplement (30-Day Supply)","description":"\u003cdiv style=\"background: #f8f9fa; border-left: 4px solid #0057a8; padding: 12px 16px; margin-bottom: 20px;\" id=\"ai-summary\"\u003e\n\u003cstrong\u003eClinical Summary:\u003c\/strong\u003e Nuchido TIME+ is a multi-pathway NAD+ restoration supplement developed by Nuchido Ltd (Edinburgh, UK) in collaboration with University of Edinburgh researchers, formulated to address age-related NAD+ decline through simultaneous action on precursor supply, competing pathway inhibition, and NAD+-consuming enzyme suppression — rather than simple NMN or NR precursor loading alone. NAD+ (nicotinamide adenine dinucleotide) declines 25–50% between ages 20 and 70, impairing mitochondrial oxidative phosphorylation (ATP synthesis), sirtuin-mediated DNA repair (SIRT1–SIRT7), and PARP-dependent genome maintenance; Nuchido TIME+ is indicated for adults seeking to support cellular energy metabolism, healthy ageing, and mitochondrial function. The 30-Day Supply (60 capsules) provides an entry-level course for initial NAD+ pathway assessment at a dose of 2 capsules daily, classified as a health supplement under the Singapore Health Products Act (Cap. 122D) and HSA Health Supplement regulations.\u003c\/div\u003e\n\u003ch2\u003eProduct Overview\u003c\/h2\u003e\n\u003cp\u003eNuchido TIME+ is a scientifically formulated NAD+ restoration supplement developed by Nuchido Ltd, a University of Edinburgh spinout founded on research into the systems biology of cellular ageing and NAD+ metabolism. NAD+ is a coenzyme present in every living cell, functioning as the central electron carrier in mitochondrial oxidative phosphorylation (the electron transport chain), as an obligatory substrate for sirtuins (SIRT1–SIRT7) — the class of NAD+-dependent deacylase enzymes that regulate gene expression, DNA damage repair, mitochondrial biogenesis, and metabolic homeostasis — and as the substrate for PARP enzymes (poly ADP-ribose polymerases) that detect and repair DNA strand breaks. Age-related NAD+ decline, documented at 25–50% reduction between ages 20 and 70 in multiple human tissue studies, compromises all three of these fundamental cellular maintenance processes.\u003c\/p\u003e\n\u003cp\u003eUnlike single-ingredient NMN (nicotinamide mononucleotide) or NR (nicotinamide riboside) supplements that supply only one NAD+ biosynthesis precursor, Nuchido TIME+ addresses the NAD+ pathway at multiple points: precursor supplementation to increase NAD+ biosynthesis input; inhibition of ACMSD (alpha-amino-beta-carboxymuconate-semialdehyde decarboxylase), which diverts tryptophan-derived intermediates away from NAD+ synthesis and towards non-productive catabolism; and suppression of CD38, a key NAD+-consuming ectoenzyme whose age-associated upregulation is a primary driver of NAD+ depletion in tissues. This multi-pathway approach is designed to elevate NAD+ more effectively and sustainably than precursor supplementation alone by simultaneously increasing synthesis input and reducing degradation output. The 30-Day Supply (60 capsules at 2 capsules per day) provides an initial course for evaluating individual response before committing to the 90-Day flagship subscription.\u003c\/p\u003e\n\u003ch2\u003eSpecifications\u003c\/h2\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eBrand\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eNuchido Ltd, Edinburgh, United Kingdom (University of Edinburgh spinout)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eProduct Name\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eNuchido TIME+ NAD Supplement — 30-Day Supply\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eCapsules per Pack\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e60 capsules (2 capsules per day)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eDuration\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e30-day supply\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMechanism\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eMulti-pathway NAD+ restoration: NAD+ precursor supply + ACMSD pathway inhibition + CD38 NAD+-consuming enzyme suppression\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eTarget Pathways\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eMitochondrial oxidative phosphorylation (ATP synthesis); Sirtuin activation (SIRT1–SIRT7): DNA repair, metabolic regulation, mitochondrial biogenesis; PARP-dependent genome maintenance\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eDosage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e2 capsules daily with food, preferably morning; peak serum NAD+ metabolite levels at approximately 1–2 hours post-ingestion\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eRegulatory — Singapore\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eClassified as a health supplement under the Singapore Health Products Act (Cap. 122D) and Health Products (Health Supplements) Regulations; HSA notification required; compliant with ASEAN Regulatory Guidelines for Traditional Medicines and Health Supplements\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003ePermitted Claims\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eSupports cellular energy metabolism; supports mitochondrial function; supports healthy ageing. Medicinal claims (disease treatment\/prevention) are not permitted for health supplements under HSA regulations\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eCountry of Origin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eUnited Kingdom\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eStore in a cool, dry place below 25°C, away from direct sunlight; keep out of reach of children\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch2\u003eKey Applications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCellular energy support in age-related NAD+ decline:\u003c\/strong\u003e Adults aged 35 and above experiencing fatigue, reduced exercise tolerance, or diminished cognitive function associated with mitochondrial energetic decline — for whom restoration of NAD+ to younger-adult levels may support subjective energy and metabolic function.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSirtuin pathway activation for healthy ageing:\u003c\/strong\u003e SIRT1 activation requires NAD+ as an obligatory substrate; SIRT1 regulates PGC-1α (mitochondrial biogenesis), FOXO3 (antioxidant defence, apoptosis regulation), and NF-κB (inflammatory gene expression). Supporting sirtuin function through NAD+ restoration is a mechanistically grounded approach to healthy ageing support.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMitochondrial function maintenance:\u003c\/strong\u003e NAD+ is essential for Complex I and Complex III of the mitochondrial electron transport chain; NAD+ depletion impairs ATP synthesis efficiency, reducing the energy available for cellular repair, immune function, and metabolic regulation. Indicated for individuals with occupational, physical, or chronological demands on cellular energy systems.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e30-day entry course before 90-day commitment:\u003c\/strong\u003e The 30-day supply (60 capsules) allows clinical assessment of individual tolerance and subjective response to NAD+ supplementation before transitioning to the cost-effective 90-day supply. Recommended as an initial trial for patients new to NAD+ pathway supplementation, particularly in Singapore's wellness medicine and longevity clinic context.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCorporate and institutional wellness programmes:\u003c\/strong\u003e Supplied to Singapore corporate wellness programmes, executive health screening clinics, and longevity medicine practices as a premium supplement component for employees and patients in high-cognitive-demand roles.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eQ: How does Nuchido TIME+ differ from single-ingredient NMN or NR supplements?\u003c\/strong\u003e\u003cbr\u003eA: Standard NMN or NR supplements provide a single NAD+ precursor, increasing biosynthesis input at one point in the Salvage pathway. Nuchido TIME+ addresses multiple regulatory nodes simultaneously: precursor supply, ACMSD pathway inhibition (redirecting tryptophan-derived intermediates towards NAD+ synthesis), and CD38 suppression (reducing NAD+ degradation). Age-related NAD+ depletion is driven both by declining synthesis and increasing degradation; addressing only the precursor side leaves the degradation driver unresolved. The theoretical advantage of multi-pathway intervention is a higher, more sustained NAD+ elevation compared to precursor-only supplementation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: What is the scientific basis for Nuchido TIME+?\u003c\/strong\u003e\u003cbr\u003eA: Nuchido Ltd was founded as a spinout of the University of Edinburgh, with scientific advisory input from researchers specialising in the systems biology of ageing and NAD+ metabolism. The company has conducted internal research on the multi-pathway NAD+ restoration approach. Peer-reviewed clinical data specifically on Nuchido TIME+ as a commercial product is limited in publicly available literature as of early 2026; the mechanistic rationale draws on published research on the roles of CD38 upregulation and ACMSD pathway competition in age-related NAD+ decline (Camacho-Pereira et al., Cell Metabolism 2016 on CD38; Rajman et al., Cell Metabolism 2018 on NAD+ and ageing). Consumers and clinicians seeking independent clinical trial data on this specific formulation should contact Nuchido Ltd directly for any available unpublished study data.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Is Nuchido TIME+ registered as a health supplement in Singapore?\u003c\/strong\u003e\u003cbr\u003eA: Nuchido TIME+ is classified as a health supplement under the Singapore Health Products Act (Cap. 122D) and the Health Products (Health Supplements) Regulations administered by the Health Sciences Authority (HSA). Health supplements in Singapore do not require pre-market approval but must be notified to HSA and comply with ingredient restrictions, labelling requirements, and permitted health claims per the ASEAN Regulatory Guidelines for Traditional Medicines and Health Supplements. Permitted claims relate to general wellbeing (e.g., \"supports cellular energy\") rather than disease treatment or prevention. EMIS sources and distributes Nuchido TIME+ through compliant channels in Singapore.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: What is the difference between the 30-Day and 90-Day supply?\u003c\/strong\u003e\u003cbr\u003eA: The 30-Day Supply (60 capsules) provides a one-month initial course at 2 capsules daily — intended for individuals trialling NAD+ supplementation for the first time or assessing individual response and tolerance. The 90-Day Supply (180 capsules) is the flagship format, providing a sustained 3-month course which aligns with the timeframe for measurable changes in mitochondrial biogenesis and sirtuin-dependent cellular remodelling processes. For ongoing supplementation, the 90-day format offers improved cost-per-day and reduces interruptions in the supplementation schedule.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Are there any contraindications or interactions to be aware of in the Singapore clinical context?\u003c\/strong\u003e\u003cbr\u003eA: As a health supplement, Nuchido TIME+ has not undergone the clinical trial programme required for pharmaceutical registration. Individuals on prescription medications — particularly those modulating PARP, sirtuin, or mTOR pathways (e.g., cancer therapies, immunosuppressants) — should consult their physician before commencing NAD+ supplementation. Nicotinamide-based compounds are generally well-tolerated; transient flushing is more commonly associated with nicotinic acid (niacin) than with NMN or NR at standard doses. Pregnant or breastfeeding individuals should avoid NAD+ supplements in the absence of specific safety data. Advice should be sought from a Singapore-registered pharmacist or physician for personalised assessment.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eAvailable in Singapore from EMIS (Essential Medical International Supplies Pte Ltd), 30-Day Supply (60 capsules). For clinic stock, corporate wellness, or B2B procurement enquiries, contact our team at emis.asia.\u003c\/em\u003e\u003c\/p\u003e\n\n\u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"FAQPage\",\n  \"mainEntity\": [\n    {\n      \"@type\": \"Question\",\n      \"name\": \"What is Nuchido TIME+ NAD Supplement (30-Day Supply) used for?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Nuchido TIME+ NAD Supplement (30-Day Supply) by Nichido is a advanced wound dressing used for wound management. It is designed to support moist wound healing, manage exudate, and protect the wound bed from contamination. It is commonly used in Singapore hospitals and home care settings for chronic wounds, post-surgical wounds, and ulcers. Always follow the guidance of your wound care nurse or doctor when selecting a dressing.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"How often should Nuchido TIME+ NAD Supplement (30-Day Supply) be changed?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Nuchido TIME+ NAD Supplement (30-Day Supply) should generally be changed every 1–7 days depending on wound type and exudate. However, frequency should always be guided by your wound care nurse or clinician based on wound size, exudate level, and signs of infection. Do not leave any dressing in place if it becomes saturated, dislodged, or if the wound shows signs of infection such as increased redness, warmth, or discharge.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Is Nuchido TIME+ NAD Supplement (30-Day Supply) available without prescription in Singapore?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Yes, Nuchido TIME+ NAD Supplement (30-Day Supply) is available for purchase from EMIS+ (emis.asia) without a prescription for general wound care use. For complex or chronic wounds, we strongly recommend consulting a wound care nurse, GP, or specialist at a Singapore hospital such as SGH, NUH, TTSH, or CGH before selecting a dressing. EMIS+ nurses can also provide product guidance — contact us at emis.asia\/pages\/contact.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Where can I buy Nuchido TIME+ NAD Supplement (30-Day Supply) in Singapore?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Nuchido TIME+ NAD Supplement (30-Day Supply) is available from EMIS+ at emis.asia, Singapore's nurse-led medical supply store. We offer fast island-wide delivery, competitive pricing, and bulk ordering for healthcare facilities and home care users. Visit emis.asia or contact our team for assistance.\"\n      }\n    }\n  ]\n}\n\u003c\/script\u003e","brand":"Nichido","offers":[{"title":"Default Title","offer_id":43056835788878,"sku":null,"price":115.0,"currency_code":"SGD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0613\/3763\/2846\/files\/Nuchido_TIME_NAD_Supplement_a740d0ab-8a63-405e-9f17-ed507551867a.png?v=1767124538","url":"https:\/\/www.emis.asia\/th-th\/products\/nuchido-time-30-day-supply","provider":"EMIS +","version":"1.0","type":"link"}