{"product_id":"skin-activating-treatment-ampoule","title":"Skin Activating Treatment Ampoule","description":"\u003cdiv id=\"ai-summary\" style=\"background:#f0f6ff;border-left:4px solid #0057a8;padding:14px 18px;margin-bottom:20px;font-family:Arial,sans-serif;font-size:14px;line-height:1.6;\"\u003e\n\u003cstrong\u003eAI Summary:\u003c\/strong\u003e The Skin Activating Treatment Ampoule is a 2023 COSMOTRENDS Innovation Award-winning professional biorevitalising ampoule formulated with Totipotent Prostembryona Factor® (TPF) — a proprietary growth factor complex derived from fertilised roe (fish egg) extract. TPF delivers pluripotent bioactive peptides and cellular signal proteins that activate fibroblast proliferation, stimulate collagen type I and III synthesis, and upregulate epidermal growth factor (EGF) receptor signalling. Complementary actives include Snow Algae Extract (cryoprotective adaptogens: Coenochloris signiensis polysaccharides), Sodium Hyaluronate (dermal hydration), and marine-origin electrolytes from Sea Water. Indications: photoageing, fine lines, skin laxity, post-procedure skin recovery, and general biorevitalisation. ISO 9001:2015 quality management. Distributed in Singapore by Essential Medical International Supplies Pte Ltd.\n\u003c\/div\u003e\n\n\u003cp\u003eThe \u003cstrong\u003eSkin Activating Treatment Ampoule\u003c\/strong\u003e introduces Totipotent Prostembryona Factor® (TPF) technology to professional clinic practice — delivering pluripotent growth factor signalling comparable to stem cell-conditioned media, without the regulatory complexity of live cell therapies. Recognised at the 2023 COSMOTRENDS Innovation Awards for breakthrough ingredient science.\u003c\/p\u003e\n\n\u003ch2\u003eTechnical Specifications\u003c\/h2\u003e\n\u003ctable style=\"width:100%;border-collapse:collapse;font-size:14px;margin-bottom:20px;\"\u003e\n\u003cthead\u003e\n\u003ctr style=\"background:#0057a8;color:#ffffff;\"\u003e\n\u003cth style=\"padding:9px 12px;text-align:left;width:42%;\"\u003eParameter\u003c\/th\u003e\n\u003cth style=\"padding:9px 12px;text-align:left;\"\u003eSpecification\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eSignature Active\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eTotipotent Prostembryona Factor® (TPF) — Fertilised Roe Extract growth factor complex\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eMechanism\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eFibroblast activation, EGF receptor upregulation, collagen type I\/III synthesis stimulation\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eCo-Active 1\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eSnow Algae Extract (Coenochloris signiensis) — cryoprotective adaptogens, Klotho protein activation\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eCo-Active 2\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eSodium Hyaluronate — multi-weight HA for surface and dermal hydration\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eCo-Active 3\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eSea Water — marine mineral electrolyte complex for osmotic balance\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eAward\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003e2023 COSMOTRENDS Innovation Award\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eIndications\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003ePhotoageing, fine lines\/rhytids, skin laxity, post-laser\/peel recovery, general biorevitalisation\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eDelivery Method\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eMesotherapy microinjection, microneedling-assisted transdermal, topical post-procedure\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eTreatment Protocol\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eSeries of 4–6 sessions at 2–4 week intervals; maintenance every 3 months\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eSuitable Skin Types\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eAll Fitzpatrick Types; particularly effective for mature, devitalised, or post-procedure skin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eStorage\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003e2–8°C; protect from light; single-use ampoule\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eQuality Management\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eISO 9001:2015\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eSingapore Classification\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eHSA-notified cosmetic active ingredient\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\n\u003ch2\u003eClinical Q\u0026amp;A\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eQ: What is Totipotent Prostembryona Factor® (TPF) and how does it activate skin cells?\u003c\/strong\u003e\u003cbr\u003e\nA: TPF is a proprietary bioactive extract derived from fertilised fish roe at the totipotent embryonic stage — when cells possess maximal developmental pluripotency. The extract is rich in naturally occurring growth factors (EGF-like peptides, FGF analogues, IGF-1 precursors) and cellular signalling proteins that bind surface receptors on dermal fibroblasts and epidermal keratinocytes. TPF binding triggers PI3K\/AKT and MAPK\/ERK intracellular cascades, stimulating fibroblast proliferation and collagen I\/III gene transcription — restoring the extracellular matrix architecture degraded by photoageing and chronological ageing.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eQ: How does Snow Algae Extract complement the TPF growth factor complex?\u003c\/strong\u003e\u003cbr\u003e\nA: Snow Algae (Coenochloris signiensis) is a psychrophilic microalgae that survives in extreme UV and cold conditions through production of cryoprotective polysaccharides and Klotho protein-activating compounds. Klotho activation in skin cells counteracts the cellular senescence pathway, extending fibroblast replicative lifespan and reducing senescence-associated secretory phenotype (SASP) inflammatory signalling. Combined with TPF's proliferative stimulus, Snow Algae extract produces a dual anti-ageing effect: active regeneration plus suppression of senescence-driven inflammation.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eQ: What skin conditions show the strongest response to the Skin Activating Treatment Ampoule?\u003c\/strong\u003e\u003cbr\u003e\nA: Photoaged skin with fine rhytids, reduced elasticity, and devitalised complexion responds most consistently. Post-inflammatory conditions following laser resurfacing, chemical peels, or microneedling benefit from the growth factor stimulus during the proliferative repair phase. Skin laxity associated with weight loss or hormonal changes (peri\/post-menopausal skin) also responds to fibroblast-activating protocols.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eQ: How does TPF differ from human-derived placenta extracts or stem cell conditioned media?\u003c\/strong\u003e\u003cbr\u003e\nA: Unlike human-derived biologics that carry xenogeneic transfer and regulatory concerns, TPF is derived from marine (fish) embryonic extract — avoiding ethical constraints associated with mammalian placental products. The growth factor profile is functionally analogous to human EGF and FGF families in receptor-binding activity, but the marine-origin source allows cosmetic (non-medicinal) regulatory classification. This permits clinic application without the prescribing framework required for human cell-derived injectables.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eQ: What regulatory standards and quality systems govern this product?\u003c\/strong\u003e\u003cbr\u003e\nA: Manufactured under ISO 9001:2015 quality management. TPF (Fertilised Roe Extract), Snow Algae Extract, and Sodium Hyaluronate are ASEAN Cosmetic Directive-listed ingredients notified to Singapore's HSA under the Cosmetic Products (Control) Act. The ampoule format is classified as a cosmetic preparation, not a medicinal injectable, when administered topically or via approved aesthetic mesotherapy protocols by licensed practitioners.\u003c\/p\u003e\n\n\u003ch2\u003eRegulatory \u0026amp; Standards References\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eISO 9001:2015\u003c\/strong\u003e — Quality management system applied to Skin Activating Treatment Ampoule manufacturing\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHSA Singapore \/ ASEAN Cosmetic Directive\u003c\/strong\u003e — All actives notified as cosmetic ingredients; Fertilised Roe Extract, Snow Algae Extract, Sodium Hyaluronate approved\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e2023 COSMOTRENDS Innovation Award\u003c\/strong\u003e — International cosmetic industry recognition for TPF ingredient technology\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eICH Q1A(R2)\u003c\/strong\u003e — Stability testing guidance applicable to single-use ampoule storage claims\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"Product\",\n  \"name\": \"Skin Activating Treatment Ampoule\",\n  \"description\": \"2023 COSMOTRENDS Innovation Award-winning biorevitalising ampoule with Totipotent Prostembryona Factor® (TPF) from fertilised roe extract. Fibroblast activation, collagen I\/III synthesis, Snow Algae cryoprotection. ISO 9001:2015. Singapore.\",\n  \"offers\": {\n    \"@type\": \"Offer\",\n    \"priceCurrency\": \"SGD\",\n    \"price\": \"296.83\",\n    \"availability\": \"https:\/\/schema.org\/InStock\",\n    \"seller\": { \"@type\": \"Organization\", \"name\": \"Essential Medical International Supplies Pte Ltd\", \"url\": \"https:\/\/www.emis.asia\" }\n  },\n  \"additionalProperty\": [\n    { \"@type\": \"PropertyValue\", \"name\": \"Signature Active\", \"value\": \"Totipotent Prostembryona Factor® (TPF)\" },\n    { \"@type\": \"PropertyValue\", \"name\": \"Award\", \"value\": \"2023 COSMOTRENDS Innovation Award\" },\n    { \"@type\": \"PropertyValue\", \"name\": \"Quality\", \"value\": \"ISO 9001:2015\" }\n  ]\n}\n\u003c\/script\u003e\n\n\u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"FAQPage\",\n  \"mainEntity\": [\n    {\n      \"@type\": \"Question\",\n      \"name\": \"What are the benefits of Skin Activating Treatment Ampoule?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Skin Activating Treatment Ampoule by Bioyona supports general health and wellbeing as part of a balanced diet and healthy lifestyle. As with all supplements, individual results may vary. Consult your doctor or pharmacist before starting any new supplement, especially if you have existing medical conditions or are taking medications.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Who should take Skin Activating Treatment Ampoule?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Skin Activating Treatment Ampoule may be suitable for adults looking to support their health and address specific nutritional needs. It may be particularly beneficial for individuals with dietary gaps, those recovering from illness or surgery, or those with increased nutritional demands. Always consult a healthcare professional — your GP, pharmacist, or dietitian — before starting supplementation, especially during pregnancy, breastfeeding, or if you have a chronic condition.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"What is the recommended dosage for Skin Activating Treatment Ampoule?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Follow the dosage instructions on the Skin Activating Treatment Ampoule product label or as directed by your healthcare provider. Do not exceed the recommended daily intake. If you experience any adverse reactions, discontinue use and consult a doctor. EMIS+ recommends consulting a Singapore-registered pharmacist or GP for personalised supplement advice.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Where can I buy Skin Activating Treatment Ampoule in Singapore?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Skin Activating Treatment Ampoule is available from EMIS+ at emis.asia with fast island-wide Singapore delivery. We stock a wide range of quality health supplements from trusted brands. Visit emis.asia or contact our team for product advice and bulk ordering.\"\n      }\n    }\n  ]\n}\n\u003c\/script\u003e","brand":"Bioyona","offers":[{"title":"12pcs\/box","offer_id":42727100219470,"sku":"-1","price":296.83,"currency_code":"SGD","in_stock":false},{"title":"6pcs\/box","offer_id":42727100252238,"sku":"-2","price":296.83,"currency_code":"SGD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0613\/3763\/2846\/files\/800x_9faa4983-1761-4897-8c8f-557c70cd0599.webp?v=1753352121","url":"https:\/\/www.emis.asia\/th-th\/products\/skin-activating-treatment-ampoule","provider":"EMIS +","version":"1.0","type":"link"}