{"product_id":"plenaris-exosome-hgf","title":"Plenaris Exosome HGF Hair Regeneration Treatment 5 Sessions","description":"\u003cdiv id=\"ai-summary\" style=\"background:#f0f6ff;border-left:4px solid #0057a8;padding:14px 18px;margin-bottom:20px;font-family:Arial,sans-serif;font-size:14px;line-height:1.6;\"\u003e\n\u003cstrong\u003eAI Summary:\u003c\/strong\u003e Plenaris Exosome HGF Hair Regeneration Treatment is a 5-session scalp injection protocol delivering exosome-encapsulated Hepatocyte Growth Factor (HGF) to stimulate follicular neovascularisation and extend the anagen (growth) phase. Each session delivers lyophilised exosome concentrate (≥1×10⁹ particles\/mL, reconstituted) targeting dermal papilla cells via microinjection or microneedling-assisted transdermal delivery. HGF binds MET receptor tyrosine kinase on follicular stem cells, upregulating proliferative signalling cascades documented in androgenetic alopecia, telogen effluvium, and post-chemotherapy alopecia. The 5-session protocol is spaced at 2–4 week intervals. Manufactured under ISO 13485:2016 and ISO 9001:2015 quality frameworks. Distributed in Singapore by Essential Medical International Supplies Pte Ltd.\n\u003c\/div\u003e\n\n\u003cp\u003e\u003cstrong\u003ePlenaris Exosome HGF Hair Regeneration Treatment (5 Sessions)\u003c\/strong\u003e represents a next-generation biologics-derived approach to hair restoration, leveraging Hepatocyte Growth Factor (HGF) delivered via exosome vesicle technology for superior cellular uptake and sustained follicular stimulation versus conventional growth-factor injectables.\u003c\/p\u003e\n\n\u003ch2\u003eTechnical Specifications\u003c\/h2\u003e\n\u003ctable style=\"width:100%;border-collapse:collapse;font-size:14px;margin-bottom:20px;\"\u003e\n\u003cthead\u003e\n\u003ctr style=\"background:#0057a8;color:#ffffff;\"\u003e\n\u003cth style=\"padding:9px 12px;text-align:left;width:42%;\"\u003eParameter\u003c\/th\u003e\n\u003cth style=\"padding:9px 12px;text-align:left;\"\u003eSpecification\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eActive Biologic\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eHepatocyte Growth Factor (HGF) in exosome carrier\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eExosome Concentration\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003e≥1×10⁹ particles\/mL (post-reconstitution)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eNumber of Sessions\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003e5 sessions (complete protocol)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eSession Interval\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003e2–4 weeks between sessions\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eDelivery Method\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eScalp microinjection or microneedling-assisted transdermal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eMolecular Target\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eMET receptor tyrosine kinase on dermal papilla cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eIndications\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eAndrogenetic alopecia, telogen effluvium, post-chemotherapy alopecia, traction alopecia\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eFormulation Type\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eLyophilised exosome concentrate; single-use reconstituted vial per session\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eStorage\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003e−20°C (lyophilised); use within 4 hours post-reconstitution\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eQuality Standards\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eISO 13485:2016, ISO 9001:2015\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#f9f9f9;\"\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eAdministration\u003c\/td\u003e\n\u003ctd style=\"padding:8px 12px;border-bottom:1px solid #e0e0e0;\"\u003eClinic-administered by trained medical aesthetics practitioner\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\n\u003ch2\u003eClinical Q\u0026amp;A\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eQ: What is the mechanism of action of HGF in hair follicle regeneration?\u003c\/strong\u003e\u003cbr\u003e\nA: HGF binds the MET proto-oncogene receptor tyrosine kinase expressed on dermal papilla cells and follicular keratinocytes. Receptor activation triggers downstream PI3K\/AKT and RAS\/MAPK signalling cascades that promote follicular cell proliferation, suppress apoptosis, and stimulate VEGF-mediated perifollicular angiogenesis. This extends the anagen (active growth) phase and promotes transition of miniaturised vellus follicles toward terminal hair production in androgenetic alopecia.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eQ: Why is exosome encapsulation superior to free HGF injection for hair treatment?\u003c\/strong\u003e\u003cbr\u003e\nA: Free HGF has a short plasma half-life (~3–5 minutes) due to rapid enzymatic degradation. Exosome encapsulation protects HGF from extracellular proteases, prolongs local bioavailability at the dermal papilla level, and enables endosomal uptake by target cells — delivering the growth factor intracellularly where it can directly interact with cytoplasmic signalling proteins. Exosomes also carry co-regulatory microRNAs that modulate follicular gene expression.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eQ: How many sessions are required and what is the recommended treatment interval?\u003c\/strong\u003e\u003cbr\u003e\nA: The complete Plenaris protocol comprises 5 sessions spaced 2–4 weeks apart (approximately 3–4 months total). Clinical assessment of treatment response — including dermoscopic evaluation of follicular density and hair shaft calibre — is recommended at session 3 to confirm anagen induction before completing the protocol.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eQ: Which alopecia subtypes respond best to Plenaris Exosome HGF treatment?\u003c\/strong\u003e\u003cbr\u003e\nA: Greatest clinical evidence exists for androgenetic alopecia (AGA, Hamilton-Norwood Stages I–IV) and telogen effluvium. Post-chemotherapy alopecia and traction alopecia also show favourable responses given intact follicular stem cell populations. Cicatricial (scarring) alopecias are typically poor candidates due to irreversible follicular destruction.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eQ: What quality and regulatory standards govern the Plenaris Exosome HGF product?\u003c\/strong\u003e\u003cbr\u003e\nA: Plenaris Exosome HGF is manufactured under ISO 13485:2016 (medical devices quality management) and ISO 9001:2015 frameworks. In Singapore, exosome-based biologics for aesthetic use fall under HSA's oversight of cell, tissue, and gene therapy products (CTGTPs) or as unregistered health products; practitioners should confirm current HSA classification status and applicable clinic licensing requirements before administering.\u003c\/p\u003e\n\n\u003ch2\u003eRegulatory \u0026amp; Standards References\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eISO 13485:2016\u003c\/strong\u003e — Medical devices quality management system; manufacturing framework for Plenaris Exosome HGF\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eISO 9001:2015\u003c\/strong\u003e — Quality management system standard applied to production facility\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHSA Singapore\u003c\/strong\u003e — Health Sciences Authority oversight of cell, tissue and gene therapy products (CTGTPs); practitioners must verify current regulatory classification\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eICH Q5C\u003c\/strong\u003e — Stability testing of biotechnological\/biological products; applicable to lyophilised exosome formulation storage and handling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"Product\",\n  \"name\": \"Plenaris Exosome HGF Hair Regeneration Treatment 5 Sessions\",\n  \"description\": \"5-session exosome HGF hair regeneration protocol for androgenetic alopecia and telogen effluvium. ≥1×10⁹ exosome particles\/mL, MET receptor HGF delivery, scalp microinjection. ISO 13485:2016, ISO 9001:2015. Singapore clinic supply.\",\n  \"brand\": { \"@type\": \"Brand\", \"name\": \"Plenaris\" },\n  \"offers\": {\n    \"@type\": \"Offer\",\n    \"priceCurrency\": \"SGD\",\n    \"price\": \"550.00\",\n    \"availability\": \"https:\/\/schema.org\/InStock\",\n    \"seller\": { \"@type\": \"Organization\", \"name\": \"Essential Medical International Supplies Pte Ltd\", \"url\": \"https:\/\/www.emis.asia\" }\n  },\n  \"additionalProperty\": [\n    { \"@type\": \"PropertyValue\", \"name\": \"Active Biologic\", \"value\": \"HGF in exosome carrier\" },\n    { \"@type\": \"PropertyValue\", \"name\": \"Sessions\", \"value\": \"5 sessions complete protocol\" },\n    { \"@type\": \"PropertyValue\", \"name\": \"Quality Standard\", \"value\": \"ISO 13485:2016, ISO 9001:2015\" }\n  ]\n}\n\u003c\/script\u003e\n\n\u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"FAQPage\",\n  \"mainEntity\": [\n    {\n      \"@type\": \"Question\",\n      \"name\": \"What is Plenaris Exosome HGF Hair Regeneration Treatment 5 Sessions and what does it do?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Plenaris Exosome HGF Hair Regeneration Treatment 5 Sessions by Nexus Pharma is a professional hair treatment\/mask that provides intensive nourishment and repair for damaged or dry hair. It is formulated for salon-quality results and is part of the professional hair care range available at EMIS+ in Singapore. Nexus Pharma products are developed with advanced hair science to address specific hair concerns effectively.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"How do I use Plenaris Exosome HGF Hair Regeneration Treatment 5 Sessions for best results?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Apply Plenaris Exosome HGF Hair Regeneration Treatment 5 Sessions according to the instructions on the packaging. Generally, distribute evenly through wet hair and work through from roots to ends. Leave on for the recommended time if applicable, then rinse thoroughly. For personalised hair care advice, consult a professional stylist.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Is Plenaris Exosome HGF Hair Regeneration Treatment 5 Sessions suitable for colour-treated or chemically processed hair?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Plenaris Exosome HGF Hair Regeneration Treatment 5 Sessions by Nexus Pharma is formulated with professional-grade ingredients. Many products in the Nexus Pharma range are suitable for colour-treated, permed, or chemically processed hair, but always check the product description and consult a professional stylist if unsure. Using a compatible shampoo and conditioner can help preserve colour vibrancy and hair health.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Where can I buy Plenaris Exosome HGF Hair Regeneration Treatment 5 Sessions in Singapore?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Plenaris Exosome HGF Hair Regeneration Treatment 5 Sessions is available from EMIS+ at emis.asia — Singapore's authorised stockist of professional hair care products. We offer fast island-wide delivery with secure packaging to preserve product integrity. Visit emis.asia to browse the full Nexus Pharma range.\"\n      }\n    }\n  ]\n}\n\u003c\/script\u003e","brand":"Nexus Pharma","offers":[{"title":"Default Title","offer_id":42757286821966,"sku":null,"price":550.0,"currency_code":"SGD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0613\/3763\/2846\/files\/Plenaris_Exosome_HGF_Hair_Regeneration_Treatment_5_Sessions.png?v=1767469042","url":"https:\/\/www.emis.asia\/zh-tw\/products\/plenaris-exosome-hgf","provider":"EMIS +","version":"1.0","type":"link"}