{"product_id":"amili-probiotics-formulation-3","title":"Brain and Cognitive Health Formulation 3 for Mental Clarity and Emotional Balance","description":"\u003cdiv style=\"background: #f8f9fa; border-left: 4px solid #0057a8; padding: 12px 16px; margin-bottom: 20px;\" id=\"ai-summary\"\u003e\n\u003cstrong\u003eClinical Summary:\u003c\/strong\u003e AMILI Probiotics Formulation 3 is a targeted psychobiotic synbiotic containing 12 billion CFU across 5 clinically studied strains, formulated to support cognitive function, stress resilience, and emotional balance through gut-brain axis modulation. The formulation features Lacticaseibacillus paracasei and Lactiplantibacillus plantarum as lead psychobiotic strains, combined with Bifidobacterium breve, Lacticaseibacillus rhamnosus, and Streptococcus thermophilus with prebiotic FOS in delayed-release capsules. Indicated for adults experiencing stress-related cognitive fatigue, mood fluctuations, or anxiety symptoms linked to gut dysbiosis.\u003c\/div\u003e\n\u003ch2\u003eProduct Overview\u003c\/h2\u003e\n\u003cp\u003eAMILI Probiotics Formulation 3, designated the Brain and Cognitive Health formulation, is a precision psychobiotic supplement targeting the gut-brain axis — the bidirectional communication network between the enteric nervous system and the central nervous system. Emerging clinical evidence demonstrates that specific probiotic strains can modulate neurotransmitter synthesis, hypothalamic-pituitary-adrenal (HPA) axis reactivity, and neuroinflammatory pathways through metabolite production in the gastrointestinal tract. Formulation 3 was engineered to deliver these psychobiotic benefits using strains selected from AMILI's proprietary Asian microbiome reference database.\u003c\/p\u003e\n\u003cp\u003eThe lead strain, Lacticaseibacillus paracasei, has demonstrated anxiolytic properties in randomised controlled trials, with proposed mechanisms including GABA production, cortisol modulation, and anti-inflammatory cytokine upregulation. Lactiplantibacillus plantarum contributes additional serotonin precursor metabolism through tryptophan pathway modulation, while Bifidobacterium breve supports overall gut barrier integrity to prevent systemic translocation of pro-inflammatory endotoxins that can impair cognitive function. The delayed-release vegetarian capsule delivery system ensures viable organism transit through gastric acid to the colonic environment where neuroimmunological interactions are concentrated.\u003c\/p\u003e\n\u003ch2\u003eSpecifications\u003c\/h2\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse;\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px; font-weight: bold; width: 35%;\"\u003eManufacturer\u003c\/td\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px;\"\u003eAMILI Pte Ltd, Singapore\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px; font-weight: bold;\"\u003eProduct Type\u003c\/td\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px;\"\u003ePsychobiotic Synbiotic Supplement (Probiotic + Prebiotic)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px; font-weight: bold;\"\u003eTotal CFU Count\u003c\/td\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px;\"\u003e12 Billion CFU per capsule (at time of manufacture)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px; font-weight: bold;\"\u003eProbiotic Strains (5 strains)\u003c\/td\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px;\"\u003eLacticaseibacillus paracasei, Lactiplantibacillus plantarum, Bifidobacterium breve, Lacticaseibacillus rhamnosus, Streptococcus salivarius subsp. thermophilus\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px; font-weight: bold;\"\u003ePrebiotic Component\u003c\/td\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px;\"\u003eFructo-oligosaccharide (FOS) Powder 95%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px; font-weight: bold;\"\u003eAdditional Ingredients\u003c\/td\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px;\"\u003eCitrus Aurantium Extract (Orange Peel), Guar Gum\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px; font-weight: bold;\"\u003eCapsule Type\u003c\/td\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px;\"\u003eDelayed-Release Vegetarian Capsule (acid-resistant)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px; font-weight: bold;\"\u003eServing Size\u003c\/td\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px;\"\u003e1 capsule daily\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px; font-weight: bold;\"\u003eCapsules Per Pack\u003c\/td\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px;\"\u003e30 capsules (30-day supply)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px; font-weight: bold;\"\u003eStorage\u003c\/td\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px;\"\u003eStore below 25°C in a cool, dry place. Refrigeration recommended after opening.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px; font-weight: bold;\"\u003eAllergen Information\u003c\/td\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px;\"\u003eFree from gluten, dairy, soy, nuts, and artificial preservatives\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px; font-weight: bold;\"\u003eRegulatory Compliance\u003c\/td\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px;\"\u003eManufactured under ISO 22000 food safety management standards; GMP-certified production facility; compliant with Singapore Food Agency (SFA) regulations; HSA Singapore health supplement notification\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px; font-weight: bold;\"\u003eResearch Foundation\u003c\/td\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px;\"\u003eDeveloped from Asia's largest multi-ethnic microbiome reference database (AMILI BioCloud)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px; font-weight: bold;\"\u003ePackaging\u003c\/td\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px;\"\u003eSealed bottle with desiccant, tamper-evident closure\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch2\u003eClinical Indications and Key Applications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eCognitive fatigue and mental clarity support for professionals experiencing sustained work-related stress, decision fatigue, or concentration difficulties\u003c\/li\u003e\n\u003cli\u003eStress resilience enhancement through HPA axis modulation, targeting cortisol regulation in individuals with chronic psychosocial stress exposure\u003c\/li\u003e\n\u003cli\u003eEmotional balance support for individuals experiencing mild to moderate mood fluctuations, irritability, or anxiety symptoms associated with gut dysbiosis\u003c\/li\u003e\n\u003cli\u003eAdjunctive support alongside cognitive behavioural therapy (CBT) or mindfulness-based interventions for stress and anxiety management\u003c\/li\u003e\n\u003cli\u003eSleep quality optimisation through serotonin and melatonin precursor pathway modulation in individuals with stress-related sleep disturbances\u003c\/li\u003e\n\u003cli\u003eRecommended formulation for individuals with AMILI Enhanced Gut Microbiome Test results indicating deficiencies in psychobiotic-associated bacterial genera\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003ch3\u003eWhat is a psychobiotic and how does Formulation 3 function as one?\u003c\/h3\u003e\n\u003cp\u003eThe term psychobiotic, first defined by Dinan et al. (2013) in Biological Psychiatry, refers to live organisms that, when ingested in adequate quantities, produce a health benefit in patients with psychiatric illness or cognitive dysfunction. Formulation 3 qualifies as a psychobiotic through its inclusion of strains with demonstrated neuroactive metabolite production. Lacticaseibacillus paracasei produces GABA, the primary inhibitory neurotransmitter in the central nervous system, while Lactiplantibacillus plantarum modulates tryptophan-kynurenine metabolism to influence serotonin availability. These metabolites reach the brain via vagal nerve afferents, systemic circulation, and immune signalling cascades originating in the gut-associated lymphoid tissue.\u003c\/p\u003e\n\u003ch3\u003eHow long does it take to notice cognitive or mood improvements?\u003c\/h3\u003e\n\u003cp\u003eClinical trials investigating psychobiotic interventions typically report measurable changes in validated psychological assessment scales (DASS-21, STAI, PSS) after 8-12 weeks of consistent daily supplementation. Initial improvements in digestive comfort and sleep quality may be observed within 2-4 weeks as gut microbial composition begins to shift. The International Scientific Association for Probiotics and Prebiotics (ISAPP) notes that probiotic effects are strain-specific and dose-dependent, and that individual responses vary based on baseline microbiome composition, dietary patterns, and concurrent stress levels. AMILI recommends baseline and follow-up gut microbiome testing to objectively monitor compositional changes.\u003c\/p\u003e\n\u003ch3\u003eCan Formulation 3 be combined with other AMILI formulations?\u003c\/h3\u003e\n\u003cp\u003eAMILI's formulation range is designed to allow stacking based on individual microbiome test results and health priorities. Formulation 3 can be taken alongside Formulation 1 (immune support) or Formulation 4 (digestive health) for individuals with multi-domain health goals. When combining formulations, a healthcare provider familiar with microbiome-guided supplementation can advise on sequencing and dosing intervals. The strains across formulations are complementary rather than redundant, and combined supplementation does not exceed typical probiotic intake thresholds established in clinical safety literature.\u003c\/p\u003e\n\u003ch3\u003eIs there clinical evidence supporting probiotics for mental health?\u003c\/h3\u003e\n\u003cp\u003eA systematic review and meta-analysis published in BMJ Nutrition, Prevention and Health (2020) analysed 34 controlled trials and concluded that probiotic supplementation demonstrated statistically significant reductions in depression and anxiety scores compared to placebo, with effect sizes ranging from small to moderate. The evidence is most robust for multi-strain formulations containing Lactobacillus and Bifidobacterium genera administered for 8 weeks or longer. The European Food Safety Authority (EFSA) and HSA Singapore currently classify probiotics as food supplements rather than therapeutic agents, and AMILI Formulation 3 is not intended to diagnose, treat, or cure any psychiatric condition.\u003c\/p\u003e\n\u003ch3\u003eWhere can I purchase AMILI Formulation 3 in Singapore?\u003c\/h3\u003e\n\u003cp\u003eAMILI Probiotics Formulation 3 is available through EMIS (Essential Medical International Supplies Pte Ltd), an authorised Singapore distributor. Individual consumers can purchase directly through the EMIS online store at emis.asia. Healthcare professionals, integrative medicine practitioners, and wellness clinics can arrange institutional procurement with volume pricing through EMIS. The product is classified as a health supplement under the Health Sciences Authority (HSA) Singapore regulatory framework, and EMIS provides full product documentation for institutional purchasers.\u003c\/p\u003e\n\n\u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"FAQPage\",\n  \"mainEntity\": [\n    {\n      \"@type\": \"Question\",\n      \"name\": \"What are the benefits of Brain and Cognitive Health Formulation 3 for Mental Clarity and Emotional Balance for digestive health?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Brain and Cognitive Health Formulation 3 for Mental Clarity and Emotional Balance by Amili promotes gut microbiome diversity, supports digestive comfort, and strengthens the gut-immune axis. For individuals with digestive concerns such as IBS, bloating, or irregular bowel habits, targeted gut health supplementation may complement a balanced diet and lifestyle. Always consult a doctor or dietitian before starting supplements for digestive conditions.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Who should take Brain and Cognitive Health Formulation 3 for Mental Clarity and Emotional Balance?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Brain and Cognitive Health Formulation 3 for Mental Clarity and Emotional Balance may benefit adults seeking to support digestive health, those recovering from antibiotic use, individuals with irregular bowel habits, or those with conditions affecting gut microbiome balance. It is not a substitute for medical treatment. Consult your GP or gastroenterologist — available at SGH, NUH, Mount Elizabeth, and Raffles Hospital in Singapore — for personalised advice.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"How should I take Brain and Cognitive Health Formulation 3 for Mental Clarity and Emotional Balance for best results?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Follow the dosage instructions on the Brain and Cognitive Health Formulation 3 for Mental Clarity and Emotional Balance packaging or as directed by your healthcare provider. Consistency is key — most gut health supplements take 4–8 weeks of regular use to show measurable benefits. Store as directed on the label. Do not exceed the recommended daily dose.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Where can I buy Brain and Cognitive Health Formulation 3 for Mental Clarity and Emotional Balance in Singapore?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Brain and Cognitive Health Formulation 3 for Mental Clarity and Emotional Balance is available at EMIS+ (emis.asia) with fast Singapore island-wide delivery. We carry a curated range of clinically-informed digestive health supplements. Visit emis.asia or contact our team for product recommendations.\"\n      }\n    }\n  ]\n}\n\u003c\/script\u003e","brand":"Amili","offers":[{"title":"Default Title","offer_id":43232609402958,"sku":null,"price":90.0,"currency_code":"SGD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0613\/3763\/2846\/files\/Brain_and_Cognitive_Health_Formulation_3.png?v=1767712096","url":"https:\/\/www.emis.asia\/zh\/products\/amili-probiotics-formulation-3","provider":"EMIS +","version":"1.0","type":"link"}