{"product_id":"amili-probiotics-formulation-4","title":"Digestive Health Formulation 4 for Microbiota Balance and Gut Resilience","description":"\u003cdiv style=\"background: #f8f9fa; border-left: 4px solid #0057a8; padding: 12px 16px; margin-bottom: 20px;\" id=\"ai-summary\"\u003e\n\u003cstrong\u003eClinical Summary:\u003c\/strong\u003e AMILI Probiotics Formulation 4 is a high-potency synbiotic containing 15 billion CFU across 5 clinically studied strains, formulated for digestive health optimisation, microbiota rebalancing, and gut resilience. The formulation is powered by Limosilactobacillus reuteri, a strain with documented anti-inflammatory and antimicrobial properties, combined with Lactiplantibacillus plantarum, Bifidobacterium breve, Lacticaseibacillus rhamnosus, and Streptococcus thermophilus with prebiotic FOS in delayed-release capsules. Indicated for adults with functional gastrointestinal symptoms, post-antibiotic dysbiosis, or microbiome test results indicating reduced digestive health biomarkers.\u003c\/div\u003e\n\u003ch2\u003eProduct Overview\u003c\/h2\u003e\n\u003cp\u003eAMILI Probiotics Formulation 4, designated the Digestive Health formulation, delivers the highest colony-forming unit count in the AMILI precision probiotics range at 15 billion CFU per capsule. This formulation addresses the foundational layer of gut health — microbial diversity, mucosal barrier integrity, and digestive function — through a five-strain consortium anchored by Limosilactobacillus reuteri. L. reuteri is among the most extensively studied probiotic organisms in gastroenterology, with over 170 published clinical trials documenting its effects on gastrointestinal motility, pathogen inhibition via reuterin production, and intestinal epithelial barrier reinforcement.\u003c\/p\u003e\n\u003cp\u003eDeveloped by AMILI Pte Ltd using strain selection informed by Asia's largest multi-ethnic gut microbiome reference database (AMILI BioCloud), Formulation 4 is calibrated for the digestive health challenges prevalent in Southeast Asian populations, including functional dyspepsia, irregular bowel habits, and antibiotic-associated microbiome disruption. The elevated 15 billion CFU dosage reflects clinical trial protocols for digestive health endpoints, where higher organism counts are associated with more consistent therapeutic responses. Delayed-release vegetarian capsules ensure organism viability through gastric acid transit, delivering viable bacteria to the colonic environment where they can establish colonisation and exert localised anti-inflammatory effects.\u003c\/p\u003e\n\u003ch2\u003eSpecifications\u003c\/h2\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse;\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px; font-weight: bold; width: 35%;\"\u003eManufacturer\u003c\/td\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px;\"\u003eAMILI Pte Ltd, Singapore\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px; font-weight: bold;\"\u003eProduct Type\u003c\/td\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px;\"\u003eHigh-Potency Synbiotic Supplement (Probiotic + Prebiotic)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px; font-weight: bold;\"\u003eTotal CFU Count\u003c\/td\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px;\"\u003e15 Billion CFU per capsule (at time of manufacture)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px; font-weight: bold;\"\u003eLead Strain\u003c\/td\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px;\"\u003eLimosilactobacillus reuteri (formerly Lactobacillus reuteri)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px; font-weight: bold;\"\u003eProbiotic Strains (5 strains)\u003c\/td\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px;\"\u003eLimosilactobacillus reuteri, Lactiplantibacillus plantarum, Bifidobacterium breve, Lacticaseibacillus rhamnosus, Streptococcus salivarius subsp. thermophilus\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px; font-weight: bold;\"\u003ePrebiotic Component\u003c\/td\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px;\"\u003eFructo-oligosaccharide (FOS) Powder 95%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px; font-weight: bold;\"\u003eAdditional Ingredients\u003c\/td\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px;\"\u003eCitrus Aurantium Extract (Orange Peel), Guar Gum\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px; font-weight: bold;\"\u003eCapsule Type\u003c\/td\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px;\"\u003eDelayed-Release Vegetarian Capsule (acid-resistant)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px; font-weight: bold;\"\u003eServing Size\u003c\/td\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px;\"\u003e1 capsule daily\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px; font-weight: bold;\"\u003eCapsules Per Pack\u003c\/td\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px;\"\u003e30 capsules (30-day supply)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px; font-weight: bold;\"\u003eStorage\u003c\/td\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px;\"\u003eStore below 25°C in a cool, dry place. Refrigeration recommended after opening.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px; font-weight: bold;\"\u003eAllergen Information\u003c\/td\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px;\"\u003eFree from gluten, dairy, soy, nuts, and artificial preservatives\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px; font-weight: bold;\"\u003eRegulatory Compliance\u003c\/td\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px;\"\u003eManufactured under ISO 22000 food safety management standards; GMP-certified production facility; compliant with Singapore Food Agency (SFA) regulations; HSA Singapore health supplement notification\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px; font-weight: bold;\"\u003eResearch Foundation\u003c\/td\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px;\"\u003eDeveloped from Asia's largest multi-ethnic microbiome reference database (AMILI BioCloud)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px; font-weight: bold;\"\u003ePackaging\u003c\/td\u003e\n\u003ctd style=\"border: 1px solid #ddd; padding: 8px;\"\u003eSealed bottle with desiccant, tamper-evident closure\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch2\u003eClinical Indications and Key Applications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eFunctional gastrointestinal symptom management including bloating, irregular bowel habits, abdominal discomfort, and functional dyspepsia in adults\u003c\/li\u003e\n\u003cli\u003ePost-antibiotic microbiome restoration and recolonisation following broad-spectrum antimicrobial therapy disrupting commensal gut bacteria\u003c\/li\u003e\n\u003cli\u003eGut barrier integrity reinforcement for individuals with increased intestinal permeability markers or chronic low-grade gastrointestinal inflammation\u003c\/li\u003e\n\u003cli\u003eTraveller's digestive health support for individuals exposed to novel microbial environments, unfamiliar dietary patterns, and water source changes\u003c\/li\u003e\n\u003cli\u003eRecommended formulation for individuals with AMILI Enhanced Gut Microbiome Test results indicating reduced microbial diversity, depleted Lactobacillus populations, or elevated pathobiont abundance\u003c\/li\u003e\n\u003cli\u003eAdjunctive digestive support for patients undergoing dietary interventions including elimination diets, low-FODMAP protocols, or therapeutic dietary transitions\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003ch3\u003eWhy does Formulation 4 contain a higher CFU count than other AMILI formulations?\u003c\/h3\u003e\n\u003cp\u003eFormulation 4 delivers 15 billion CFU per capsule compared to 9 billion (Formulation 1) and 12 billion (Formulations 2 and 3) because clinical trial evidence for digestive health endpoints consistently demonstrates dose-dependent responses. A meta-analysis published in the American Journal of Gastroenterology analysing probiotic interventions for functional gastrointestinal disorders found that formulations delivering 10 billion CFU or higher produced statistically significant improvements in global symptom scores, while lower doses showed inconsistent effects. The elevated count in Formulation 4 also compensates for organism attrition during gastrointestinal transit, ensuring therapeutic colony counts reach the colon.\u003c\/p\u003e\n\u003ch3\u003eWhat makes Limosilactobacillus reuteri the lead strain for digestive health?\u003c\/h3\u003e\n\u003cp\u003eL. reuteri is one of the most extensively characterised probiotic organisms in gastroenterology, with unique antimicrobial properties derived from its production of reuterin (3-hydroxypropionaldehyde), a broad-spectrum antimicrobial compound active against gram-positive and gram-negative pathogens. L. reuteri has also demonstrated the ability to modulate gastrointestinal motility through enteric nervous system interactions, reduce visceral pain perception, and strengthen tight junction protein expression in the intestinal epithelium. The World Gastroenterology Organisation (WGO) Global Guidelines list L. reuteri among recommended probiotic strains for multiple gastrointestinal indications.\u003c\/p\u003e\n\u003ch3\u003eCan Formulation 4 be used during antibiotic treatment?\u003c\/h3\u003e\n\u003cp\u003eProbiotic supplementation during antibiotic therapy is supported by clinical evidence, with a Cochrane systematic review demonstrating that concurrent probiotic use reduces antibiotic-associated diarrhoea incidence by approximately 42%. When taking Formulation 4 alongside antibiotics, a minimum 2-hour separation between antibiotic and probiotic doses is recommended to reduce direct antimicrobial exposure to the probiotic organisms. Supplementation should continue for at least 2-4 weeks after completing the antibiotic course to support microbiome recovery. Healthcare providers in Singapore should consider individual patient factors including antibiotic class, treatment duration, and patient history when advising on concurrent probiotic use.\u003c\/p\u003e\n\u003ch3\u003eHow does this formulation compare to generic digestive health probiotics available in pharmacies?\u003c\/h3\u003e\n\u003cp\u003eAMILI Formulation 4 differs from mass-market digestive probiotics in three key aspects: strain selection based on Asian population microbiome data rather than Western reference databases; delayed-release capsule technology ensuring colonic delivery rather than standard capsules where organisms are exposed to gastric acid; and a higher 15 billion CFU count reflecting clinical trial dosing protocols. Additionally, AMILI products are developed by a microbiome science company with proprietary metagenomic sequencing capabilities, and can be paired with the AMILI Enhanced Gut Microbiome Test for personalised baseline assessment and progress monitoring.\u003c\/p\u003e\n\u003ch3\u003eWhere can healthcare practitioners in Singapore procure AMILI Formulation 4?\u003c\/h3\u003e\n\u003cp\u003eAMILI Probiotics Formulation 4 is distributed in Singapore through EMIS (Essential Medical International Supplies Pte Ltd). Gastroenterology clinics, integrative medicine practices, functional medicine practitioners, and wellness centres can arrange institutional procurement with volume pricing. The product is classified as a health supplement under the Health Sciences Authority (HSA) Singapore regulatory framework. EMIS provides Certificates of Analysis, batch traceability documentation, and dedicated account management for healthcare institution partners requiring regulatory compliance documentation.\u003c\/p\u003e\n\n\u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"FAQPage\",\n  \"mainEntity\": [\n    {\n      \"@type\": \"Question\",\n      \"name\": \"What are the benefits of Digestive Health Formulation 4 for Microbiota Balance and Gut Resilience for digestive health?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Digestive Health Formulation 4 for Microbiota Balance and Gut Resilience by Amili promotes gut microbiome diversity, supports digestive comfort, and strengthens the gut-immune axis. For individuals with digestive concerns such as IBS, bloating, or irregular bowel habits, targeted gut health supplementation may complement a balanced diet and lifestyle. Always consult a doctor or dietitian before starting supplements for digestive conditions.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Who should take Digestive Health Formulation 4 for Microbiota Balance and Gut Resilience?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Digestive Health Formulation 4 for Microbiota Balance and Gut Resilience may benefit adults seeking to support digestive health, those recovering from antibiotic use, individuals with irregular bowel habits, or those with conditions affecting gut microbiome balance. It is not a substitute for medical treatment. Consult your GP or gastroenterologist — available at SGH, NUH, Mount Elizabeth, and Raffles Hospital in Singapore — for personalised advice.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"How should I take Digestive Health Formulation 4 for Microbiota Balance and Gut Resilience for best results?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Follow the dosage instructions on the Digestive Health Formulation 4 for Microbiota Balance and Gut Resilience packaging or as directed by your healthcare provider. Consistency is key — most gut health supplements take 4–8 weeks of regular use to show measurable benefits. Store as directed on the label. Do not exceed the recommended daily dose.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Where can I buy Digestive Health Formulation 4 for Microbiota Balance and Gut Resilience in Singapore?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Digestive Health Formulation 4 for Microbiota Balance and Gut Resilience is available at EMIS+ (emis.asia) with fast Singapore island-wide delivery. We carry a curated range of clinically-informed digestive health supplements. Visit emis.asia or contact our team for product recommendations.\"\n      }\n    }\n  ]\n}\n\u003c\/script\u003e","brand":"Amili","offers":[{"title":"Default Title","offer_id":43232609435726,"sku":null,"price":90.0,"currency_code":"SGD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0613\/3763\/2846\/files\/Digestive_Health_Formulation_4_for_Microbiota_Balance_and_Gut_Resilience.png?v=1767712011","url":"https:\/\/www.emis.asia\/zh\/products\/amili-probiotics-formulation-4","provider":"EMIS +","version":"1.0","type":"link"}