{"product_id":"c-e-ferulic-vitamin-c-serum","title":"SkinCeuticals C E Ferulic® Vitamin C Serum — Advanced Antioxidant Protection for Radiant, Firm, Youthful Skin","description":"\u003cdiv style=\"background: #f8f9fa; border-left: 4px solid #0057a8; padding: 12px 16px; margin-bottom: 20px;\" id=\"ai-summary\"\u003e\n\u003cstrong\u003eClinical Summary:\u003c\/strong\u003e SkinCeuticals C E Ferulic is a clinically validated antioxidant serum containing 15% L-ascorbic acid, 1% alpha tocopherol, and 0.5% ferulic acid, formulated at an acidic pH (2.2–3.5) to maximize cutaneous bioavailability. The synergistic combination reduces combined oxidative damage from UVA, UVB, ozone, and diesel exhaust particulate by up to 41%, while stimulating Type I and Type III collagen synthesis via prolyl and lysyl hydroxylase enzyme cofactor activity. Indicated for photoaged skin, hyperpigmentation, loss of epidermal firmness, and daily antioxidant maintenance in high-pollution urban environments such as Singapore.\u003c\/div\u003e\n\u003ch2\u003eProduct Overview\u003c\/h2\u003e\n\u003cp\u003eSkinCeuticals C E Ferulic is a synergistic antioxidant serum developed through research at Duke University Medical Center under the direction of Dr. Sheldon R. Pinnell, MD. The formulation delivers pure L-ascorbic acid (vitamin C) at 15% concentration alongside alpha tocopherol (vitamin E) at 1% and ferulic acid at 0.5%. The acidic delivery vehicle (pH 2.2–3.5) maintains ascorbic acid in its biologically active, reduced form and facilitates penetration across the stratum corneum into viable epidermis and dermis. Duke University holds the foundational patent for this stable aqueous antioxidant combination, licensed to SkinCeuticals.\u003c\/p\u003e\n\u003cp\u003eTopical application prior to sunscreen provides a second line of defence against UV-induced reactive oxygen species (ROS) and free radical cascades. L-ascorbic acid functions as a direct electron donor to neutralise superoxide, hydroxyl, and peroxyl radicals. Alpha tocopherol replenishes oxidised vitamin C and provides lipophilic antioxidant activity within cell membranes. Ferulic acid, a plant-derived phenolic compound, further stabilises both vitamins C and E against photodegradation while contributing independent radical-scavenging activity — an effect documented in peer-reviewed photobiology literature.\u003c\/p\u003e\n\u003ch2\u003eSpecifications\u003c\/h2\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eBrand\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eSkinCeuticals\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eProduct Name\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eC E Ferulic with 15% L-Ascorbic Acid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eKey Actives\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eL-Ascorbic Acid 15%, Alpha Tocopherol 1%, Ferulic Acid 0.5%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eFormulation pH\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e2.2–3.5 (aqueous, acidic)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eVolume\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e30 mL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSkin Types\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eNormal, dry, and sensitive; all phototype classifications\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eApplication Frequency\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eOnce daily (morning), after cleansing, before moisturiser and SPF\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eRegulatory (Singapore)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eClassified as cosmetic product under Singapore Health Products Act and ASEAN Cosmetic Directive Regulations 2007; HSA notification required\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eClinical Evidence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eDuke University photobiology studies; 41% combined oxidative damage reduction; Pinnell et al., peer-reviewed publications\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eStore below 25°C, away from direct sunlight; discard if solution turns orange or brown\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eCountry of Origin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eUnited States\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch2\u003eKey Applications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePhotoaged skin management:\u003c\/strong\u003e Daily topical antioxidant application to counteract cumulative UV-induced collagen degradation, elastin disruption, and matrix metalloproteinase (MMP) upregulation in chronically sun-exposed Singapore residents.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePost-procedure adjunct:\u003c\/strong\u003e Clinician-recommended post-laser, post-chemical peel, and post-microneedling antioxidant support to reduce procedural oxidative stress and promote fibroblast-mediated collagen remodelling.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHyperpigmentation control:\u003c\/strong\u003e Tyrosinase inhibition by L-ascorbic acid reduces melanin synthesis and assists management of post-inflammatory hyperpigmentation (PIH), solar lentigines, and melasma in conjunction with medical treatment protocols.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePreventive antioxidant coverage in high-pollution environments:\u003c\/strong\u003e Neutralisation of ROS generated by urban air pollutants (ozone, diesel particulate matter), relevant for Singapore's high-UV, high-humidity equatorial climate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCollagen synthesis support:\u003c\/strong\u003e Vitamin C acts as obligatory cofactor for prolyl and lysyl hydroxylase enzymes responsible for hydroxylation of procollagen chains, supporting Type I and Type III collagen cross-linking and extracellular matrix stability.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdjunctive photoprotection:\u003c\/strong\u003e Used in conjunction with broad-spectrum SPF 30+ sunscreen as part of a dual antioxidant photoprotection strategy per evidence-based dermatology practice.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Why must C E Ferulic be applied in the morning rather than at night?\u003c\/strong\u003e\u003cbr\u003eA: The formulation is designed to be in place on the skin before UV and environmental oxidant exposure occurs. Antioxidants neutralise ROS at the point of generation; applying the serum at night provides no meaningful protection against daytime oxidative insults. Duke University photobiology research confirms that topical application prior to UV exposure significantly attenuates UV-induced oxidative DNA damage and immunosuppression.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Is there a risk of skin irritation from the low-pH acidic formulation in Singapore's humid climate?\u003c\/strong\u003e\u003cbr\u003eA: L-ascorbic acid at 15% and pH 2.2–3.5 may cause transient tingling or mild erythema in barrier-compromised or sensitive skin, particularly in humid conditions. A slow introduction protocol is recommended: apply every other day for two weeks, then daily once tolerance is established. Patients with rosacea, eczema, or active barrier disruption should consult a dermatologist before initiating use.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: How should C E Ferulic be layered with prescription topicals such as tretinoin or hydroquinone?\u003c\/strong\u003e\u003cbr\u003eA: C E Ferulic is applied in the morning; tretinoin and hydroquinone are typically prescribed for nocturnal use to avoid photosensitisation. This temporal separation eliminates formulation interaction risks. If a clinician prescribes daytime hydroquinone, application of C E Ferulic should precede it after a one-to-two-minute absorption window.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: How is this product regulated and sourced in Singapore?\u003c\/strong\u003e\u003cbr\u003eA: SkinCeuticals C E Ferulic is classified as a cosmetic product under the Singapore Health Products Act (Cap. 122D) and the Health Products (Cosmetic Products — ASEAN Cosmetic Directive) Regulations 2007, administered by the Health Sciences Authority (HSA). EMIS sources authentic product through authorised distributor channels. Clinics and aesthetic medicine practices should retain distributor invoices and HSA notification records for compliance documentation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: What is the expected shelf life and how does oxidation affect efficacy?\u003c\/strong\u003e\u003cbr\u003eA: Unopened product: 24 months from manufacture date when stored below 25°C away from light and air. Once opened, use within 3–6 months. L-ascorbic acid oxidises progressively; a solution that changes from pale straw-yellow to orange or brown has undergone significant oxidation, substantially reducing antioxidant efficacy. Oxidised product should be discarded.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eAvailable in Singapore from EMIS (Essential Medical International Supplies Pte Ltd). For professional procurement enquiries, contact our B2B team at emis.asia.\u003c\/em\u003e\u003c\/p\u003e\n\n\u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"FAQPage\",\n  \"mainEntity\": [\n    {\n      \"@type\": \"Question\",\n      \"name\": \"What are the benefits of SkinCeuticals C E Ferulic® Vitamin C Serum — Advanced Antioxidant Protection for Radiant, Firm, Yout for digestive health?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"SkinCeuticals C E Ferulic® Vitamin C Serum — Advanced Antioxidant Protection for Radiant, Firm, Yout by SkinCeuticals supports digestive health and gut wellbeing. For individuals with digestive concerns such as IBS, bloating, or irregular bowel habits, targeted gut health supplementation may complement a balanced diet and lifestyle. Always consult a doctor or dietitian before starting supplements for digestive conditions.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Who should take SkinCeuticals C E Ferulic® Vitamin C Serum — Advanced Antioxidant Protection for Radiant, Firm, Yout?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"SkinCeuticals C E Ferulic® Vitamin C Serum — Advanced Antioxidant Protection for Radiant, Firm, Yout may benefit adults seeking to support digestive health, those recovering from antibiotic use, individuals with irregular bowel habits, or those with conditions affecting gut microbiome balance. It is not a substitute for medical treatment. Consult your GP or gastroenterologist — available at SGH, NUH, Mount Elizabeth, and Raffles Hospital in Singapore — for personalised advice.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"How should I take SkinCeuticals C E Ferulic® Vitamin C Serum — Advanced Antioxidant Protection for Radiant, Firm, Yout for best results?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Follow the dosage instructions on the SkinCeuticals C E Ferulic® Vitamin C Serum — Advanced Antioxidant Protection for Radiant, Firm, Yout packaging or as directed by your healthcare provider. Consistency is key — most gut health supplements take 4–8 weeks of regular use to show measurable benefits. Store as directed on the label. Do not exceed the recommended daily dose.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Where can I buy SkinCeuticals C E Ferulic® Vitamin C Serum — Advanced Antioxidant Protection for Radiant, Firm, Yout in Singapore?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"SkinCeuticals C E Ferulic® Vitamin C Serum — Advanced Antioxidant Protection for Radiant, Firm, Yout is available at EMIS+ (emis.asia) with fast Singapore island-wide delivery. We carry a curated range of clinically-informed digestive health supplements. Visit emis.asia or contact our team for product recommendations.\"\n      }\n    }\n  ]\n}\n\u003c\/script\u003e","brand":"SkinCeuticals","offers":[{"title":"30 ml","offer_id":43041847771214,"sku":"635494363210","price":285.0,"currency_code":"SGD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0613\/3763\/2846\/files\/SkinCeuticals_C_E_Ferulic_Vitamin_C_Serum_1.png?v=1767126893","url":"https:\/\/www.emis.asia\/zh\/products\/c-e-ferulic-vitamin-c-serum","provider":"EMIS +","version":"1.0","type":"link"}