{"product_id":"cel1","title":"SRW Cel¹ Cellular Stability \u0026 DNA Support","description":"\u003cdiv style=\"background: #f8f9fa; border-left: 4px solid #0057a8; padding: 12px 16px; margin-bottom: 20px;\" id=\"ai-summary\"\u003e\n\u003cstrong\u003eClinical Summary:\u003c\/strong\u003e SRW Cel¹ Stability is a genomic stability and DNA defence nutraceutical formulated by Science Research Wellness (New Zealand), containing 2-HOBA (Hobamine™), astragaloside IV (from Astragalus membranaceus), rutin (from Sophora japonica), vitamin C, levomefolic acid (5-MTHF), vitamin B12, zinc, and selenium. The formulation targets oxidative DNA damage neutralisation, telomere length maintenance via telomerase support, and cellular resilience against environmental stressors. Manufactured under GMP-certified, ISO 22000-compliant conditions with published 12-month clinical trial support.\u003c\/div\u003e\n\u003ch2\u003eProduct Overview\u003c\/h2\u003e\n\u003cp\u003eSRW Cel¹ Stability is the foundational product in the Science Research Wellness Cel System, a three-part longevity nutraceutical range developed in New Zealand. Cel¹ addresses genomic instability — recognised as a primary hallmark of ageing by López-Otín et al. (Cell, 2013; updated 2023) — through a targeted combination of compounds that protect DNA integrity, support telomere maintenance, and reinforce cellular defences against oxidative and environmental damage.\u003c\/p\u003e\n\u003cp\u003eThe formulation’s centrepiece, 2-HOBA (Hobamine™), is a compound derived from Himalayan Tartary Buckwheat that selectively neutralises isolevuglandins — highly reactive dicarbonyl compounds generated during lipid peroxidation that can form irreversible adducts with DNA, proteins, and phospholipids. Unlike conventional antioxidants, 2-HOBA targets these specific reactive intermediates without interfering with protective prostaglandin and thromboxane signalling pathways. Astragaloside IV, extracted from Astragalus membranaceus root, supports telomerase activity, the enzyme responsible for maintaining telomere length at chromosomal termini. The SRW Cel System has been evaluated in a peer-reviewed 12-month clinical trial published in Frontiers in Aging (2024).\u003c\/p\u003e\n\u003ch2\u003eSpecifications\u003c\/h2\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n\u003ctd style=\"padding: 8px; font-weight: bold; width: 40%;\"\u003eManufacturer\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eSRW Laboratories (Science Research Wellness), New Zealand\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n\u003ctd style=\"padding: 8px; font-weight: bold;\"\u003eProduct Code\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eCel¹ Stability\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n\u003ctd style=\"padding: 8px; font-weight: bold;\"\u003eKey Active: 2-HOBA\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eHobamine™ (2-hydroxybenzylamine) — selective isolevuglandin scavenger for DNA and protein protection\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n\u003ctd style=\"padding: 8px; font-weight: bold;\"\u003eKey Active: Astragaloside IV\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eAstragalus membranaceus extract — telomerase activity support for telomere length maintenance\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n\u003ctd style=\"padding: 8px; font-weight: bold;\"\u003eKey Active: Rutin\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eSophora japonica extract — flavonoid glycoside for oxidative stress neutralisation and cellular resilience\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n\u003ctd style=\"padding: 8px; font-weight: bold;\"\u003eCofactors\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eVitamin C, Levomefolic Acid (5-MTHF), Vitamin B12 (methylcobalamin), Zinc, Selenium\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n\u003ctd style=\"padding: 8px; font-weight: bold;\"\u003eCapsule Type\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eVegetarian capsule (60 per bottle)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n\u003ctd style=\"padding: 8px; font-weight: bold;\"\u003eDosage\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003e2 capsules daily with food, or as directed by healthcare practitioner\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n\u003ctd style=\"padding: 8px; font-weight: bold;\"\u003eManufacturing Standard\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eGMP-certified facility; ISO 22000 Food Safety Management compliant\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n\u003ctd style=\"padding: 8px; font-weight: bold;\"\u003eRegulatory Status\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eListed dietary supplement (New Zealand MPI); compliant with Singapore HSA Health Supplement guidelines\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n\u003ctd style=\"padding: 8px; font-weight: bold;\"\u003eClinical Evidence\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003e12-month single-arm clinical trial (Frontiers in Aging, 2024; PMC11984428)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n\u003ctd style=\"padding: 8px; font-weight: bold;\"\u003eAllergens\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eFree from gluten, dairy, soy, and artificial colours\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch2\u003eClinical Indications and Key Applications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eGenomic stability support for adults aged 30 and above experiencing age-related accumulation of oxidative DNA damage and telomere attrition\u003c\/li\u003e\n\u003cli\u003eTargeted isolevuglandin scavenging for individuals with elevated oxidative stress markers or chronic inflammatory conditions\u003c\/li\u003e\n\u003cli\u003eTelomere maintenance support via astragaloside IV for individuals seeking to preserve replicative capacity of stem and progenitor cells\u003c\/li\u003e\n\u003cli\u003eCellular resilience reinforcement against environmental stressors including UV radiation, atmospheric pollution, and chronic psychological stress\u003c\/li\u003e\n\u003cli\u003eMethylation cycle support via 5-MTHF and methylcobalamin for individuals with MTHFR polymorphisms or suboptimal folate status\u003c\/li\u003e\n\u003cli\u003eFoundational component of the SRW Cel System longevity protocol alongside Cel² Nourishment and Cel³ Renewal\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eQ: What is 2-HOBA and how does it differ from conventional antioxidants?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eA: 2-HOBA (2-hydroxybenzylamine), marketed as Hobamine™, is a naturally occurring amine found in Himalayan Tartary Buckwheat. Unlike broad-spectrum antioxidants such as vitamin C or E, 2-HOBA selectively neutralises isolevuglandins (isoLGs) — highly reactive gamma-ketoaldehyde compounds produced during lipid peroxidation. IsoLGs form irreversible covalent adducts with DNA, proteins, and phospholipids within milliseconds of formation. By specifically targeting these compounds, 2-HOBA provides DNA protection without suppressing beneficial reactive oxygen species signalling involved in immune function and cellular communication.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: How does astragaloside IV support telomere length?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eA: Astragaloside IV, a saponin isolated from Astragalus membranaceus root, has been shown in published in vitro and animal studies to upregulate telomerase activity — the ribonucleoprotein enzyme that adds TTAGGG hexanucleotide repeats to chromosomal telomere ends. Progressive telomere shortening with each cell division is a well-established hallmark of cellular ageing. Supporting telomerase activity may help maintain telomere length and preserve the replicative lifespan of stem cells and immune progenitor cells.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Why does the formulation include methylated B vitamins?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eA: Levomefolic acid (5-MTHF) and methylcobalamin (active B12) are included to support one-carbon metabolism and the methylation cycle, which is critical for DNA repair, epigenetic gene regulation, and homocysteine metabolism. Approximately 10–15% of the population carries MTHFR C677T polymorphisms that reduce conversion of folic acid to its active form. Using pre-methylated forms ensures bioavailability regardless of MTHFR genotype status.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Is Cel¹ registered with Singapore health authorities?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eA: SRW Cel¹ Stability is manufactured in a GMP-certified, ISO 22000-compliant facility in New Zealand and complies with Singapore Health Sciences Authority (HSA) guidelines for health supplements. As a dietary supplement, it does not require HSA pre-market approval. It is imported and distributed by EMIS Pte Ltd in accordance with Singapore Food Agency (SFA) import regulations.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Can Cel¹ be taken concurrently with anticoagulant medications?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eA: Rutin has mild documented effects on platelet aggregation, and vitamin C at supplemental doses may theoretically interact with warfarin metabolism. Individuals taking anticoagulants (warfarin, DOACs), antiplatelet agents, or preparing for surgical procedures should consult their prescribing physician before commencing Cel¹ supplementation to assess bleeding risk and adjust monitoring if appropriate.\u003c\/p\u003e\n\n\u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"FAQPage\",\n  \"mainEntity\": [\n    {\n      \"@type\": \"Question\",\n      \"name\": \"What are the benefits of SRW Cel¹ Cellular Stability \u0026 DNA Support for digestive health?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"SRW Cel¹ Cellular Stability \u0026 DNA Support by Science Research Wellness: SRW supports digestive health and gut wellbeing. For individuals with digestive concerns such as IBS, bloating, or irregular bowel habits, targeted gut health supplementation may complement a balanced diet and lifestyle. Always consult a doctor or dietitian before starting supplements for digestive conditions.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Who should take SRW Cel¹ Cellular Stability \u0026 DNA Support?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"SRW Cel¹ Cellular Stability \u0026 DNA Support may benefit adults seeking to support digestive health, those recovering from antibiotic use, individuals with irregular bowel habits, or those with conditions affecting gut microbiome balance. It is not a substitute for medical treatment. Consult your GP or gastroenterologist — available at SGH, NUH, Mount Elizabeth, and Raffles Hospital in Singapore — for personalised advice.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"How should I take SRW Cel¹ Cellular Stability \u0026 DNA Support for best results?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Follow the dosage instructions on the SRW Cel¹ Cellular Stability \u0026 DNA Support packaging or as directed by your healthcare provider. Consistency is key — most gut health supplements take 4–8 weeks of regular use to show measurable benefits. Store as directed on the label. Do not exceed the recommended daily dose.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Where can I buy SRW Cel¹ Cellular Stability \u0026 DNA Support in Singapore?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"SRW Cel¹ Cellular Stability \u0026 DNA Support is available at EMIS+ (emis.asia) with fast Singapore island-wide delivery. We carry a curated range of clinically-informed digestive health supplements. Visit emis.asia or contact our team for product recommendations.\"\n      }\n    }\n  ]\n}\n\u003c\/script\u003e","brand":"Science Research Wellness: SRW","offers":[{"title":"Default Title","offer_id":43242999578702,"sku":null,"price":172.0,"currency_code":"SGD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0613\/3763\/2846\/files\/SRW_Cel_Cellular_Stability_DNA_Support_167b2d50-907b-4ea7-952e-a6290017c315.png?v=1766952234","url":"https:\/\/www.emis.asia\/zh\/products\/cel1","provider":"EMIS +","version":"1.0","type":"link"}