{"product_id":"cel3-renewal","title":"SRW Cel³ Renewal Advanced Cellular Health \u0026 Anti Aging Formula","description":"\u003cdiv style=\"background: #f8f9fa; border-left: 4px solid #0057a8; padding: 12px 16px; margin-bottom: 20px;\" id=\"ai-summary\"\u003e\n\u003cstrong\u003eClinical Summary:\u003c\/strong\u003e SRW Cel³ Renewal is a senolytic and cellular renewal nutraceutical formulated by Science Research Wellness (New Zealand), containing a proprietary blend of fisetin (from Cotinus coggygria, 10%), oleuropein (from Olea europaea, 40%), EGCG (from Camellia sinensis, 50%), berberine (from Cortex phellodendri, 50%), withaferin A (from Ashwagandha, 5%), alpha lipoic acid, and apigenin (100 mg). The formulation targets senescent cell clearance, autophagy activation, and cellular housekeeping pathways analogous to fasting-mimetic mechanisms. Manufactured under GMP-certified, ISO 22000-compliant conditions with published clinical trial support.\u003c\/div\u003e\n\u003ch2\u003eProduct Overview\u003c\/h2\u003e\n\u003cp\u003eSRW Cel³ Renewal is a scientifically formulated cellular renewal supplement developed by Science Research Wellness, a New Zealand biotechnology company specialising in longevity and cellular health nutraceuticals. The product was formulated by Dr. Chris Meletis, a naturopathic physician with over 250 published scientific articles and 12 books on nutraceutical science. Cel³ targets three interconnected hallmarks of ageing: cellular senescence (the accumulation of dysfunctional “zombie” cells that secrete pro-inflammatory cytokines), impaired autophagy (reduced cellular waste clearance), and dysregulated nutrient sensing.\u003c\/p\u003e\n\u003cp\u003eThe formulation employs a multi-compound senolytic and autophagy-activating strategy. Fisetin, the primary senolytic agent, has demonstrated selective clearance of senescent cells in preclinical models published in EBioMedicine (2018). Apigenin supports NAD+ homeostasis and autophagy induction, while oleuropein from olive leaf extract promotes the natural recycling of cellular components. The combined mechanism mirrors aspects of intermittent fasting at the cellular level, supporting cellular housekeeping without caloric restriction. The SRW Cel System has been evaluated in a 12-month clinical trial published in Frontiers in Aging (2024).\u003c\/p\u003e\n\u003ch2\u003eSpecifications\u003c\/h2\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n\u003ctd style=\"padding: 8px; font-weight: bold; width: 40%;\"\u003eManufacturer\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eSRW Laboratories (Science Research Wellness), New Zealand\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n\u003ctd style=\"padding: 8px; font-weight: bold;\"\u003eProduct Code\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eCel³ Renewal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n\u003ctd style=\"padding: 8px; font-weight: bold;\"\u003eProprietary Blend\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003e1,100 mg per 2-capsule serve\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n\u003ctd style=\"padding: 8px; font-weight: bold;\"\u003eKey Active: Fisetin\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eCotinus coggygria extract standardised to 10% fisetin — natural senolytic compound\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n\u003ctd style=\"padding: 8px; font-weight: bold;\"\u003eKey Active: Oleuropein\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eOlea europaea (olive leaf) extract standardised to 40% oleuropein — autophagy support\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n\u003ctd style=\"padding: 8px; font-weight: bold;\"\u003eKey Active: EGCG\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eCamellia sinensis extract standardised to 50% EGCG — cellular protection\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n\u003ctd style=\"padding: 8px; font-weight: bold;\"\u003eKey Active: Berberine\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eCortex phellodendri extract standardised to 50% berberine — AMPK activation and nutrient sensing\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n\u003ctd style=\"padding: 8px; font-weight: bold;\"\u003eKey Active: Withaferin A\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eAshwagandha extract standardised to 5% withaferin A — senolytic and adaptogenic support\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n\u003ctd style=\"padding: 8px; font-weight: bold;\"\u003eAdditional Actives\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eAlpha Lipoic Acid; Apigenin 100 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n\u003ctd style=\"padding: 8px; font-weight: bold;\"\u003eCapsule Type\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eDelayed-release vegetarian capsule (60 per bottle)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n\u003ctd style=\"padding: 8px; font-weight: bold;\"\u003eDosage\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003e2 capsules daily with food, or as directed by healthcare practitioner\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n\u003ctd style=\"padding: 8px; font-weight: bold;\"\u003eManufacturing Standard\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eGMP-certified facility; ISO 22000 Food Safety Management compliant\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n\u003ctd style=\"padding: 8px; font-weight: bold;\"\u003eRegulatory Status\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eListed dietary supplement (New Zealand MPI); compliant with Singapore HSA Health Supplement guidelines\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n\u003ctd style=\"padding: 8px; font-weight: bold;\"\u003eClinical Evidence\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003e12-month clinical trial (Frontiers in Aging, 2024; PMC11984428)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"border-bottom: 1px solid #ddd;\"\u003e\n\u003ctd style=\"padding: 8px; font-weight: bold;\"\u003eAllergens\u003c\/td\u003e\n\u003ctd style=\"padding: 8px;\"\u003eFree from gluten, dairy, soy, and artificial colours\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch2\u003eClinical Indications and Key Applications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eSenolytic support for adults aged 35 and above seeking to reduce the burden of senescent cells associated with chronic low-grade inflammation (inflammaging)\u003c\/li\u003e\n\u003cli\u003eAutophagy activation and cellular waste clearance support for individuals unable to maintain regular intermittent fasting protocols\u003c\/li\u003e\n\u003cli\u003eComplementary cellular renewal support alongside anti-ageing, exercise, and dietary optimisation programmes\u003c\/li\u003e\n\u003cli\u003eAMPK pathway activation via berberine for individuals seeking metabolic efficiency and nutrient-sensing regulation\u003c\/li\u003e\n\u003cli\u003eAntioxidant and cellular protection support for individuals exposed to chronic environmental stressors (UV, pollution, psychological stress)\u003c\/li\u003e\n\u003cli\u003eAdjunctive nutritional support for longevity-focused health protocols when used in combination with SRW Cel¹ Stability and Cel² Nourishment\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eQ: What are senolytic compounds and how does fisetin work?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eA: Senolytic compounds selectively target and promote the clearance of senescent cells — aged, dysfunctional cells that resist normal apoptosis and accumulate with age, secreting pro-inflammatory factors (the senescence-associated secretory phenotype, or SASP). Fisetin, a naturally occurring flavonoid, has demonstrated senolytic activity in preclinical research published in EBioMedicine (2018), showing selective reduction of senescent cell markers in multiple tissue types without affecting healthy proliferating cells.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: How does Cel³ mimic the effects of fasting?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eA: Several active ingredients in Cel³ activate cellular pathways typically induced by caloric restriction or intermittent fasting. Berberine activates AMPK (AMP-activated protein kinase), a key metabolic sensor triggered during energy deficit states. Oleuropein and EGCG support autophagy — the cellular self-cleaning process upregulated during fasting. Apigenin supports NAD+ levels, further enhancing the cellular energy-sensing cascade. Together, these compounds provide fasting-mimetic cellular benefits without requiring dietary restriction.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Is this product suitable for concurrent use with prescription medications?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eA: Berberine has documented interactions with CYP450 enzyme substrates, including certain statins, antidiabetic medications, and immunosuppressants. EGCG may affect iron absorption and certain hepatically metabolised drugs. Individuals taking prescription medications should consult their healthcare practitioner before commencing Cel³, particularly those on metformin, warfarin, or CYP3A4 substrates.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: What is the recommended protocol for the full SRW Cel System?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eA: The SRW Cel System comprises Cel¹ Stability (genomic protection and telomere maintenance), Cel² Nourishment (NAD+ and mitochondrial energy), and Cel³ Renewal (senolytic clearance and autophagy). Used together, the three formulations address multiple hallmarks of ageing as defined by López-Otín et al. (Cell, 2013; updated 2023). The 12-month clinical trial evaluated the combined protocol and reported significant improvements in epigenetic age markers.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Is Cel³ Renewal registered with Singapore health authorities?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eA: Cel³ is manufactured in a GMP-certified, ISO 22000-compliant facility in New Zealand and complies with Singapore Health Sciences Authority (HSA) guidelines for health supplements. As a dietary supplement, it does not require HSA pre-market approval. It is imported and distributed by EMIS Pte Ltd in accordance with Singapore Food Agency (SFA) import regulations.\u003c\/p\u003e\n\n\u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"FAQPage\",\n  \"mainEntity\": [\n    {\n      \"@type\": \"Question\",\n      \"name\": \"What are the benefits of SRW Cel³ Renewal Advanced Cellular Health \u0026 Anti Aging Formula for digestive health?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"SRW Cel³ Renewal Advanced Cellular Health \u0026 Anti Aging Formula by Science Research Wellness: SRW supports digestive health and gut wellbeing. For individuals with digestive concerns such as IBS, bloating, or irregular bowel habits, targeted gut health supplementation may complement a balanced diet and lifestyle. Always consult a doctor or dietitian before starting supplements for digestive conditions.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Who should take SRW Cel³ Renewal Advanced Cellular Health \u0026 Anti Aging Formula?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"SRW Cel³ Renewal Advanced Cellular Health \u0026 Anti Aging Formula may benefit adults seeking to support digestive health, those recovering from antibiotic use, individuals with irregular bowel habits, or those with conditions affecting gut microbiome balance. It is not a substitute for medical treatment. Consult your GP or gastroenterologist — available at SGH, NUH, Mount Elizabeth, and Raffles Hospital in Singapore — for personalised advice.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"How should I take SRW Cel³ Renewal Advanced Cellular Health \u0026 Anti Aging Formula for best results?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Follow the dosage instructions on the SRW Cel³ Renewal Advanced Cellular Health \u0026 Anti Aging Formula packaging or as directed by your healthcare provider. Consistency is key — most gut health supplements take 4–8 weeks of regular use to show measurable benefits. Store as directed on the label. Do not exceed the recommended daily dose.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Where can I buy SRW Cel³ Renewal Advanced Cellular Health \u0026 Anti Aging Formula in Singapore?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"SRW Cel³ Renewal Advanced Cellular Health \u0026 Anti Aging Formula is available at EMIS+ (emis.asia) with fast Singapore island-wide delivery. We carry a curated range of clinically-informed digestive health supplements. Visit emis.asia or contact our team for product recommendations.\"\n      }\n    }\n  ]\n}\n\u003c\/script\u003e","brand":"Science Research Wellness: SRW","offers":[{"title":"Default Title","offer_id":43243002036302,"sku":null,"price":172.0,"currency_code":"SGD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0613\/3763\/2846\/files\/SRW_Cel_Renewal_Advanced_Cellular_Health_Anti_Aging_Formula_bc36b879-b04b-4258-8dc2-d025a38bc8fc.png?v=1766952061","url":"https:\/\/www.emis.asia\/zh\/products\/cel3-renewal","provider":"EMIS +","version":"1.0","type":"link"}