{"product_id":"nuchido-time-90-day-subscription","title":"Nuchido TIME+™ NAD Supplement (90 Days)","description":"\u003cdiv style=\"background: #f8f9fa; border-left: 4px solid #0057a8; padding: 12px 16px; margin-bottom: 20px;\" id=\"ai-summary\"\u003e\n\u003cstrong\u003eClinical Summary:\u003c\/strong\u003e Nuchido TIME+ is a UK-formulated cellular health supplement that uses a systems-biology stack of nicotinamide, parsley-derived apigenin, sophora japonica flavonoids (quercetin, rutin, troxerutin), green tea extract, alpha lipoic acid, vitamin C, and zinc to restore endogenous NAD+ production. A peer-reviewed double-blind crossover trial published in npj Aging (Nature Portfolio, 2024) reported a mean 242 percent increase in cellular NAD+ at 16 days, alongside upregulation of NAMPT and SIRT1 and reductions in pro-inflammatory cytokines and glycated serum protein. The 90-day pack supplies three months of daily dosing for adults pursuing structured longevity, healthspan, or post-illness cellular recovery protocols.\u003c\/div\u003e\n\u003ch2\u003eProduct Overview\u003c\/h2\u003e\n\u003cp\u003eNuchido TIME+ is manufactured by Nuchido Laboratories Ltd (United Kingdom) and represents a third-generation NAD+ intervention. Rather than supplying NAD+ precursors alone (e.g. nicotinamide riboside or nicotinamide mononucleotide), the formulation applies a systems-biology approach that simultaneously addresses the three principal mechanisms of age-associated NAD+ decline: insufficient precursor availability, impaired NAD+ salvage pathway activity (specifically reduced NAMPT enzyme expression), and excessive NAD+ consumption by chronic inflammatory pathways and CD38 activity. This multi-target architecture is the basis on which Nuchido distinguishes its product from single-precursor competitors.\u003c\/p\u003e\n\u003cp\u003eThe 90-day pack contains three monthly bottles supplying a continuous daily dose for adults aged 30 and above seeking to maintain or restore cellular NAD+ levels. The clinical evidence base includes a randomised, double-blind, crossover human trial (Dollerup et al., npj Aging, 2024) in 26 participants aged 20-80 years, demonstrating significant elevation of whole-blood NAD+, increased SIRT1 and NAMPT expression in peripheral blood mononuclear cells, reduction in plasma pro-inflammatory cytokines including IL-2, and a measurable decrease in glycated serum protein, indicating downstream metabolic benefit.\u003c\/p\u003e\n\u003ch2\u003eSpecifications\u003c\/h2\u003e\n\u003ctable style=\"border-collapse: collapse; width: 100%;\" cellspacing=\"0\" cellpadding=\"6\" border=\"1\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth align=\"left\"\u003eManufacturer\u003c\/th\u003e\n\u003ctd\u003eNuchido Laboratories Ltd, United Kingdom\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth align=\"left\"\u003ePack Size\u003c\/th\u003e\n\u003ctd\u003e90-day supply (3 x 30-day bottles, monthly subscription or one-off purchase)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth align=\"left\"\u003eDaily Dose\u003c\/th\u003e\n\u003ctd\u003e2 capsules with breakfast\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth align=\"left\"\u003eActive Ingredients\u003c\/th\u003e\n\u003ctd\u003eNicotinamide, Parsley leaf extract (apigenin source), Sophora japonica extract (quercetin, rutin, troxerutin), Green tea extract (EGCG), Alpha Lipoic Acid, Vitamin C (ascorbic acid), Zinc, Black Pepper extract (piperine, bioavailability enhancer)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth align=\"left\"\u003eMechanism\u003c\/th\u003e\n\u003ctd\u003eMulti-target NAD+ system support: precursor supply, NAMPT salvage upregulation, CD38 inhibition, anti-inflammatory NAD+ preservation\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth align=\"left\"\u003eClinical Evidence\u003c\/th\u003e\n\u003ctd\u003eRandomised double-blind crossover human trial: 242% mean increase in cellular NAD+ at 16 days (Dollerup et al., npj Aging 2024, doi:10.1038\/s41514-023-00134-0)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth align=\"left\"\u003eCapsule Type\u003c\/th\u003e\n\u003ctd\u003eVegan; gluten-free; non-GMO\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth align=\"left\"\u003eExcludes\u003c\/th\u003e\n\u003ctd\u003eWheat, dairy, soy, artificial colours and preservatives\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth align=\"left\"\u003eManufacturing Standards\u003c\/th\u003e\n\u003ctd\u003eUK GMP-certified facility; ISO 22000 food safety; ISO 9001 quality management\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth align=\"left\"\u003eRegulatory\u003c\/th\u003e\n\u003ctd\u003eUK MHRA food supplement compliance; EU EFSA novel food assessment passed; HSA Singapore health supplement notification framework\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth align=\"left\"\u003eStorage\u003c\/th\u003e\n\u003ctd\u003eStore below 25°C in a dry place, away from direct sunlight\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth align=\"left\"\u003eShelf Life\u003c\/th\u003e\n\u003ctd\u003e24 months from manufacture; refer to bottle for batch-specific expiry\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch2\u003eClinical Indications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eAdults aged 30 and above pursuing structured cellular ageing, healthspan, or longevity protocols\u003c\/li\u003e\n\u003cli\u003ePatients with measured low cellular NAD+ via metabolomic testing (e.g. Jinfiniti or comparable assay)\u003c\/li\u003e\n\u003cli\u003eAdjunct nutritional support for metabolic syndrome, insulin resistance, or pre-diabetes given documented reduction in glycated serum protein\u003c\/li\u003e\n\u003cli\u003eRecovery support after acute illness, antibiotic courses, or sustained inflammatory states where NAD+ depletion is anticipated\u003c\/li\u003e\n\u003cli\u003ePatients on chronic medications associated with mitochondrial stress (statins, metformin) seeking to restore cellular bioenergetics\u003c\/li\u003e\n\u003cli\u003eIndividuals integrating NAD+ optimisation into a broader regimen of resistance training, time-restricted eating, and sleep optimisation\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003ch3\u003eHow does Nuchido TIME+ differ from NMN or NR supplements?\u003c\/h3\u003e\n\u003cp\u003eNMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) are direct NAD+ precursors that supply substrate for NAD+ synthesis. Nuchido TIME+ supplies a precursor (nicotinamide) plus a stack of bioactives that upregulates the NAMPT salvage enzyme, inhibits CD38-mediated NAD+ degradation, and reduces inflammation-driven NAD+ consumption. The published clinical evidence reporting a 242 percent NAD+ increase at 16 days is among the larger effect sizes documented for any oral NAD+ intervention to date.\u003c\/p\u003e\n\u003ch3\u003eIs Nuchido TIME+ supported by peer-reviewed evidence?\u003c\/h3\u003e\n\u003cp\u003eYes. The pivotal clinical trial (Dollerup et al., npj Aging, Nature Portfolio, 2024) was a double-blind, randomised, placebo-controlled crossover study. The methodology and outcomes have been peer-reviewed and indexed on PubMed. Buyers should review the open-access publication directly and discuss the data with a qualified healthcare provider familiar with longevity medicine.\u003c\/p\u003e\n\u003ch3\u003eWhat is the safety profile?\u003c\/h3\u003e\n\u003cp\u003eIn the 26-participant clinical trial, very few adverse effects were reported: two participants noted disturbed sleep when taking Nuchido TIME+ and one reported transient stomach irritation. The supplement is not recommended during pregnancy or lactation, in children under 18, or in patients on chemotherapy, immunosuppressive therapy, or strong CYP3A4-modulating drugs without prior physician review. Patients with known allergy to soy, parsley, or sophora-derived flavonoids should avoid the product.\u003c\/p\u003e\n\u003ch3\u003eHow is the product regulated for sale in Singapore?\u003c\/h3\u003e\n\u003cp\u003eNuchido TIME+ is supplied as a health supplement under the Singapore HSA framework, which does not require pre-market product registration but mandates compliance with the Health Products Act and labelling, ingredient permissibility, and contaminant limits. EMIS+ sources stock through the Nuchido authorised channel, ensuring batch documentation, certificate of analysis availability, and cold-chain integrity from manufacture to delivery.\u003c\/p\u003e\n\u003ch3\u003eWhy purchase the 90-day pack rather than the 30-day pack?\u003c\/h3\u003e\n\u003cp\u003eThe clinical trial used 28 days of continuous daily dosing to establish baseline NAD+ elevation; sustained cellular and inflammatory adaptations are reported with longer regimens. The 90-day pack ensures uninterrupted dosing across a full quarterly cycle, supports compliance, and offers improved per-day economics for patients committing to a structured longevity protocol.\u003c\/p\u003e","brand":"Nichido","offers":[{"title":"Default Title","offer_id":43056835854414,"sku":null,"price":289.0,"currency_code":"SGD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0613\/3763\/2846\/files\/Nuchido_TIME_NAD_Supplement_1.png?v=1767124472","url":"https:\/\/www.emis.asia\/zh\/products\/nuchido-time-90-day-subscription","provider":"EMIS +","version":"1.0","type":"link"}