{"product_id":"precision-microbiome-map","title":"Precision Microbiome Map","description":"\u003cdiv style=\"background: #f8f9fa; border-left: 4px solid #0057a8; padding: 12px 16px; margin-bottom: 20px;\" id=\"ai-summary\"\u003e\n\u003cstrong\u003eClinical Summary:\u003c\/strong\u003e The Precision Microbiome Map is a whole-metagenome shotgun sequencing (WMS) gut microbiome analysis service that profiles bacterial species, strains, and functional gene pathways from a stool sample, providing resolution an order of magnitude beyond standard 16S rRNA amplicon sequencing. Results are benchmarked against a multi-ethnic Asian microbiome reference database to generate clinically actionable reports including dysbiosis scoring, enterotype classification, gut-brain axis neurotransmitter precursor capacity, intestinal permeability risk markers, and metabolic syndrome-associated microbial signatures. The service is indicated for individuals with chronic gastrointestinal complaints, immune dysregulation, metabolic disease, mental health concerns with putative gut-brain axis involvement, and clinical practitioners establishing a microbiome baseline prior to probiotic, prebiotic, dietary, or pharmacological interventions in Singapore.\u003c\/div\u003e\n\u003ch2\u003eProduct Overview\u003c\/h2\u003e\n\u003cp\u003eThe Precision Microbiome Map is an advanced gut microbiome profiling service available through EMIS+ in Singapore, employing whole-metagenome shotgun sequencing (WMS) to characterise the full genomic content of the gut microbiome — bacteria, archaea, fungi, and viruses — at species and strain resolution. Unlike 16S rRNA amplicon sequencing, which targets a single conserved gene region and cannot reliably distinguish closely related species or quantify functional gene content, WMS sequences all DNA present in the sample, enabling both taxonomic identification at the strain level and comprehensive functional pathway analysis. The test identifies over 1,000 microbial species and maps metabolic pathways including short-chain fatty acid (SCFA) production, bile acid metabolism, tryptophan and serotonin biosynthesis, lipopolysaccharide production capacity, and antibiotic resistance gene (ARG) prevalence — data that is directly relevant to gastrointestinal, immunological, metabolic, and neuropsychiatric health.\u003c\/p\u003e\n\u003cp\u003eResults are interpreted against a proprietary multi-ethnic Asian gut microbiome reference database, which is critically important for Singaporean patients. Large-scale microbiome databases used by most commercial tests are predominantly derived from Western (European and North American) populations, which differ significantly from Asian populations in diet, enterotype distribution, and microbial diversity benchmarks. Benchmarking against an Asian-representative reference population increases the specificity and clinical relevance of dysbiosis detection, reduces false-positive flagging of Asian-common bacteria as pathological, and enables more accurate personalisation of dietary and probiotic recommendations for individuals in Singapore's multi-ethnic population. The service includes a detailed clinical report, personalised dietary and supplement recommendations based on identified microbiome deficits, and a repeat test protocol designed for post-intervention monitoring.\u003c\/p\u003e\n\u003ch2\u003eSpecifications\u003c\/h2\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 14px;\" cellspacing=\"0\" cellpadding=\"8\" border=\"1\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSequencing Technology\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eWhole-metagenome shotgun sequencing (WMS); Illumina NovaSeq platform\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSequencing Depth\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eMinimum 10 million reads per sample; typical depth 15–20 million reads\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eResolution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eSpecies and strain-level identification; \u0026gt;1,000 microbial species profiled\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003evs. 16S rRNA\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eWMS provides 10–100x greater taxonomic resolution and full functional gene pathway data; 16S cannot distinguish strain-level differences or quantify metabolic function\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eReference Database\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eMulti-ethnic Asian gut microbiome reference database; Southeast Asian population-representative cohort\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSample Type\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eStool sample (self-collected); stabilisation buffer included for ambient temperature transport\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eTurnaround Time\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e4–6 weeks from sample receipt at laboratory\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eISO Compliance\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eLaboratory operations compliant with ISO 15189:2022 for medical laboratory quality; sequencing facility holds ISO 9001:2015 certification\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eRegulatory Status (Singapore)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eConsumer microbiome wellness service; not classified as an IVD medical device under HSA Health Products (Medical Devices) Regulations 2010\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eReports Included\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eTaxonomic composition, diversity indices (Shannon, Simpson), dysbiosis score, enterotype, functional pathway map, personalised dietary and probiotic recommendations\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eFunctional Pathways Reported\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eSCFA production, bile acid metabolism, tryptophan\/serotonin biosynthesis, intestinal permeability markers, antibiotic resistance genes (ARGs), inflammation-associated microbes\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch2\u003eClinical Indications and Applications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChronic gastrointestinal disorders:\u003c\/strong\u003e Establishing a microbiome baseline for individuals with irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), functional dyspepsia, or unexplained bloating and altered bowel habits, enabling targeted probiotic and dietary intervention based on specific dysbiosis patterns identified at species resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolic syndrome and type 2 diabetes:\u003c\/strong\u003e Profiling metabolic syndrome-associated microbial signatures including reduced Akkermansia muciniphila, Faecalibacterium prausnitzii, and butyrate-producing Lachnospiraceae, alongside elevated Prevotella and LPS-producing Proteobacteria — patterns correlated with insulin resistance and glycaemic dysregulation in multiple Asian-population studies.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmune dysregulation and autoimmune conditions:\u003c\/strong\u003e Identifying microbiome patterns associated with intestinal permeability, low microbial diversity, and reduced regulatory T-cell–promoting bacteria (Clostridia clusters IV and XIV), relevant for practitioners managing IBD, psoriasis, rheumatoid arthritis, and atopic dermatitis in Singapore.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMental health and gut-brain axis assessment:\u003c\/strong\u003e Quantifying neurotransmitter precursor-producing microbes including serotonin producers (Enterochromaffin cells, Clostridiales), GABA producers (Lactobacillus and Bifidobacterium spp.), and tryptophan metabolisers, relevant for patients with depression, anxiety, or sleep disorders with suspected gut-brain axis involvement.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePre- and post-intervention microbiome monitoring:\u003c\/strong\u003e Providing baseline and follow-up data to quantify microbiome shifts in response to antibiotic therapy (and subsequent recovery), probiotic or prebiotic supplementation, dietary modification (e.g. Mediterranean diet adoption), or faecal microbiota transplantation (FMT) protocols.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePreventive health and longevity programmes:\u003c\/strong\u003e Integrating microbiome data into corporate health screening, longevity programme baselines, or annual preventive health panels for individuals seeking a multi-system biological assessment beyond conventional blood biomarkers.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eQ: What is the clinical advantage of whole-metagenome shotgun sequencing over 16S rRNA testing?\u003c\/strong\u003e\u003cbr\u003eA: The 16S rRNA gene is a single conserved genomic region used to classify bacteria at the genus level in most consumer gut tests. It cannot reliably distinguish species within a genus (e.g. cannot differentiate Lactobacillus rhamnosus from L. acidophilus), cannot detect fungi or viruses, and cannot assess metabolic gene content. WMS sequences all DNA in the sample, enabling strain-level bacterial identification, full eukaryotic and viral profiling, and comprehensive functional pathway analysis — including SCFA production capacity, ARG burden, and specific enzyme-level metabolic functions. For clinical decision-making involving targeted probiotic selection or antibiotic stewardship, WMS provides materially superior data.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Why is an Asian-specific microbiome reference database important for Singaporean patients?\u003c\/strong\u003e\u003cbr\u003eA: The gut microbiome composition differs substantially between populations due to differences in diet, genetics, and early-life microbial exposure. Most commercial tests (e.g. Thryve, Viome, Atlas) benchmark against predominantly Caucasian reference cohorts. Using these references to assess Singaporean patients can falsely flag Asian-common bacteria as dysbiotic, underestimate healthy diversity ranges for Asian enterotypes, and generate dietary recommendations calibrated to Western food patterns. The Precision Microbiome Map uses an Asian-representative reference database, significantly improving the specificity and clinical relevance of results for Chinese, Malay, and Indian Singaporean populations.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Can this test diagnose specific diseases such as colorectal cancer or IBD?\u003c\/strong\u003e\u003cbr\u003eA: The Precision Microbiome Map is a wellness and research-grade microbiome profiling service, not a diagnostic medical device as defined under the HSA Health Products (Medical Devices) Regulations 2010. It does not produce a clinical diagnosis. While certain microbial signatures are statistically associated with conditions including colorectal cancer (e.g. elevated Fusobacterium nucleatum), IBD (e.g. Faecalibacterium prausnitzii depletion), and type 2 diabetes, these associations are correlational. Patients with symptoms suggestive of gastrointestinal disease should seek evaluation from a Singapore-registered gastroenterologist. The microbiome data can usefully complement, but does not replace, clinical investigation and endoscopic or laboratory diagnostic workup.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: How is the stool sample collected and transported in Singapore's climate?\u003c\/strong\u003e\u003cbr\u003eA: The collection kit includes a stool collection device and a nucleic acid stabilisation buffer that preserves microbial DNA at ambient temperature for up to 72 hours — important for Singapore's tropical climate where unpreserved samples degrade rapidly. Samples are collected at home, transferred to the stabilisation tube, and shipped to the processing laboratory within the designated window. Detailed instructions are provided with the kit, and EMIS+ support is available for collection queries.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: What follow-up support is provided after receiving microbiome results?\u003c\/strong\u003e\u003cbr\u003eA: The Precision Microbiome Map report includes personalised dietary modification recommendations, targeted probiotic strain suggestions based on identified deficits, and lifestyle guidance relevant to the specific dysbiosis patterns identified. For individuals requiring clinical interpretation in the context of a medical condition, EMIS+ can facilitate referral to partner practitioners in Singapore with microbiome medicine expertise. Repeat testing at 3–6 month intervals following a structured intervention is recommended to objectively assess microbiome response.\u003c\/p\u003e\n\n\u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"FAQPage\",\n  \"mainEntity\": [\n    {\n      \"@type\": \"Question\",\n      \"name\": \"What is Precision Microbiome Map used for?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Precision Microbiome Map by EMIS + is an ostomy care product designed to support stoma management and protect peristomal skin. It is suitable for use with colostomy, ileostomy, and urostomy pouching systems. For personalised advice on your pouching system, consult a Wound, Ostomy and Continence (WOC) nurse at SGH, NUH, CGH, or TTSH in Singapore.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Is Precision Microbiome Map suitable for all stoma types — colostomy, ileostomy, and urostomy?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Most EMIS + stoma care products are designed to be compatible with all stoma types. However, the right product depends on your individual stoma location, output type, and skin condition. An enterostomal therapist (ET nurse) at a Singapore hospital can help you select the most appropriate products for your specific pouching system.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"How do I use Precision Microbiome Map correctly?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Always refer to the product instructions included with Precision Microbiome Map. In general, ensure peristomal skin is clean and dry before application, measure your stoma accurately, and change your pouching system every 1–3 days or when leakage is suspected. If you experience peristomal skin irritation, soreness, or persistent leakage, contact a WOC nurse or EMIS+ team for advice.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Where can I buy Precision Microbiome Map in Singapore?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Precision Microbiome Map is available from EMIS+ at emis.asia — Singapore's trusted nurse-led stoma supply store. We stock a comprehensive range of ostomy products with fast island-wide delivery. Bulk orders for home care and nursing facilities are welcome. Contact us at emis.asia\/pages\/contact.\"\n      }\n    }\n  ]\n}\n\u003c\/script\u003e","brand":"EMIS +","offers":[{"title":"Default Title","offer_id":43526037733454,"sku":null,"price":399.0,"currency_code":"SGD","in_stock":true}],"url":"https:\/\/www.emis.asia\/zh\/products\/precision-microbiome-map","provider":"EMIS +","version":"1.0","type":"link"}