{"product_id":"resveratrol-b-e","title":"SkinCeuticals Resveratrol B E — Advanced Nighttime Antioxidant Serum for Firm, Radiant, Youthful Skin","description":"\u003cdiv style=\"background: #f8f9fa; border-left: 4px solid #0057a8; padding: 12px 16px; margin-bottom: 20px;\" id=\"ai-summary\"\u003e\n\u003cstrong\u003eClinical Summary:\u003c\/strong\u003e SkinCeuticals Resveratrol B E is a stabilised nighttime antioxidant concentrate formulated with 1% pure resveratrol, 0.5% baicalin, and 1% alpha-tocopherol (vitamin E) to activate sirtuin-mediated cellular repair pathways and neutralise free radical damage accumulated during daytime environmental exposure. The synergistic antioxidant combination is supported by peer-reviewed research demonstrating clinically significant improvements in skin density, firmness, and radiance following 12-week use. Manufactured by SkinCeuticals (L'Oréal Group) under ISO 22716:2007 GMP standards and available in Singapore through EMIS for dermatology and aesthetic clinic procurement.\u003c\/div\u003e\n\u003ch2\u003eSkinCeuticals Resveratrol B E — Product Overview\u003c\/h2\u003e\n\u003cp\u003eSkinCeuticals Resveratrol B E is a nighttime antioxidant treatment containing a maximised concentration of resveratrol — a stilbene polyphenol derived from \u003cem\u003ePolygonum cuspidatum\u003c\/em\u003e (Japanese knotweed) — combined with baicalin (a flavone extracted from \u003cem\u003eScutellaria baicalensis\u003c\/em\u003e) and alpha-tocopherol (vitamin E). The formulation targets the skin's circadian repair window during sleep to amplify cellular antioxidant activity through three complementary mechanisms: sirtuin-1 (SIRT1) enzyme pathway activation by resveratrol, broad-spectrum free radical scavenging by baicalin, and lipid-phase membrane antioxidant protection by alpha-tocopherol. This multi-pathway approach addresses oxidative damage from UV radiation, visible light, and particulate pollution accumulated during daytime exposure in Singapore's urban environment.\u003c\/p\u003e\n\u003cp\u003eIn a double-blind, placebo-controlled clinical study (n=30, 12 weeks), Resveratrol B E demonstrated statistically significant improvements in skin density, firmness, and surface radiance versus untreated control. Baicalin at 0.5% has been shown in independent in vitro and ex vivo studies to stabilise the resveratrol molecule against oxidative degradation and to act synergistically with resveratrol to enhance SIRT1 pathway activity beyond that achieved by either ingredient alone. The product is manufactured under L'Oréal's ISO 22716:2007-certified Good Manufacturing Practice standards and is notified as a cosmetic product under the Singapore Health Sciences Authority (HSA) Health Products Act (Cap. 122D), compliant with the ASEAN Cosmetic Directive.\u003c\/p\u003e\n\u003ch2\u003eProduct Specifications\u003c\/h2\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 14px;\"\u003e\n\u003cthead\u003e\n\u003ctr style=\"background: #0057a8; color: #fff;\"\u003e\n\u003cth style=\"padding: 8px; text-align: left; border: 1px solid #ddd;\"\u003eParameter\u003c\/th\u003e\n\u003cth style=\"padding: 8px; text-align: left; border: 1px solid #ddd;\"\u003eSpecification\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr style=\"background: #fff;\"\u003e\n\u003ctd style=\"padding: 8px; border: 1px solid #ddd;\"\u003e\u003cstrong\u003eManufacturer\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"padding: 8px; border: 1px solid #ddd;\"\u003eSkinCeuticals (L'Oréal Group), France\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background: #f9f9f9;\"\u003e\n\u003ctd style=\"padding: 8px; border: 1px solid #ddd;\"\u003e\u003cstrong\u003eSKU \/ EAN Barcode\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"padding: 8px; border: 1px solid #ddd;\"\u003e3606000498747\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background: #fff;\"\u003e\n\u003ctd style=\"padding: 8px; border: 1px solid #ddd;\"\u003e\u003cstrong\u003eNet Volume\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"padding: 8px; border: 1px solid #ddd;\"\u003e30 mL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background: #f9f9f9;\"\u003e\n\u003ctd style=\"padding: 8px; border: 1px solid #ddd;\"\u003e\u003cstrong\u003eKey Active Ingredients\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"padding: 8px; border: 1px solid #ddd;\"\u003e1% Pure Resveratrol (\u003cem\u003ePolygonum cuspidatum\u003c\/em\u003e root extract); 0.5% Baicalin (\u003cem\u003eScutellaria baicalensis\u003c\/em\u003e); 1% Alpha-Tocopherol (Vitamin E)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background: #fff;\"\u003e\n\u003ctd style=\"padding: 8px; border: 1px solid #ddd;\"\u003e\u003cstrong\u003eFormulation Type\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"padding: 8px; border: 1px solid #ddd;\"\u003eLightweight serum concentrate; aqueous-silicone phase; paraben-free, fragrance-free, dye-free\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background: #f9f9f9;\"\u003e\n\u003ctd style=\"padding: 8px; border: 1px solid #ddd;\"\u003e\u003cstrong\u003eApplication Timing\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"padding: 8px; border: 1px solid #ddd;\"\u003eNighttime only; apply post-cleanse, before moisturiser\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background: #fff;\"\u003e\n\u003ctd style=\"padding: 8px; border: 1px solid #ddd;\"\u003e\u003cstrong\u003eSuitable Skin Types\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"padding: 8px; border: 1px solid #ddd;\"\u003eNormal, dry, combination, sensitive; compatible with all Fitzpatrick phototypes\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background: #f9f9f9;\"\u003e\n\u003ctd style=\"padding: 8px; border: 1px solid #ddd;\"\u003e\u003cstrong\u003eManufacturing Standard\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"padding: 8px; border: 1px solid #ddd;\"\u003eISO 22716:2007 Good Manufacturing Practices for Cosmetics\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background: #fff;\"\u003e\n\u003ctd style=\"padding: 8px; border: 1px solid #ddd;\"\u003e\u003cstrong\u003eRegulatory Status (Singapore)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"padding: 8px; border: 1px solid #ddd;\"\u003eCosmetic product notified under HSA Health Products Act (Cap. 122D); compliant with ASEAN Cosmetic Directive\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background: #f9f9f9;\"\u003e\n\u003ctd style=\"padding: 8px; border: 1px solid #ddd;\"\u003e\u003cstrong\u003eRetail Price (Singapore)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"padding: 8px; border: 1px solid #ddd;\"\u003eSGD 285 per 30 mL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background: #fff;\"\u003e\n\u003ctd style=\"padding: 8px; border: 1px solid #ddd;\"\u003e\u003cstrong\u003eStorage Conditions\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"padding: 8px; border: 1px solid #ddd;\"\u003e15–25°C; protect from direct sunlight; do not freeze\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch2\u003eClinical Indications and Aesthetic Applications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePhotoaged skin with fine lines and surface irregularity:\u003c\/strong\u003e Resveratrol's SIRT1 pathway activation supports nocturnal DNA repair and collagen synthesis; indicated as an adjunct to daytime photoprotection in patients with Fitzpatrick II–V photodamage presenting with dyschromia, rhytides, or loss of skin density.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePost-procedure skin recovery:\u003c\/strong\u003e Suitable for use in the recovery phase following ablative laser resurfacing, medium-depth chemical peels, or microneedling once re-epithelialisation is complete; antioxidant load supports tissue remodelling and reduces post-inflammatory oxidative stress.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePerimenopause-associated skin laxity and accelerated ageing:\u003c\/strong\u003e Resveratrol and alpha-tocopherol combination addresses accelerated oxidative damage and collagen degradation associated with oestrogen decline; clinical data support improvements in firmness and skin density relevant to this patient cohort.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e24-hour antioxidant protocol in aesthetic clinic programmes:\u003c\/strong\u003e Designed as a nighttime complement to daytime vitamin C antioxidants (e.g., SkinCeuticals C E Ferulic, Phloretin CF) for comprehensive oxidative protection against UV, infrared, and air pollution insults in Singapore's high-UV equatorial climate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePatients on topical retinoid therapy requiring antioxidant support:\u003c\/strong\u003e The fragrance-free, paraben-free formulation is well tolerated alongside topical tretinoin or adapalene; may be alternated or layered nightly with minimal additive irritation risk.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLongevity and cellular health programmes:\u003c\/strong\u003e Incorporated by functional medicine and integrative clinicians given resveratrol's established SIRT1 activator mechanism, complementary to oral NAD+ precursor supplementation targeting the same sirtuinpathway.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eQ: What is the mechanism of resveratrol in this topical formulation?\u003c\/strong\u003e\u003cbr\u003eA: Resveratrol is a stilbene polyphenol that activates sirtuin deacetylase enzymes — specifically SIRT1 — which regulate oxidative stress response, DNA repair, and mitochondrial biogenesis at the cellular level. Applied topically at 1%, resveratrol penetrates to the viable epidermis and delivers antioxidant defence via both direct free radical scavenging and upregulation of endogenous antioxidant enzymes including superoxide dismutase and catalase. The baicalin co-formulated at 0.5% synergistically enhances SIRT1 activation and stabilises resveratrol against oxidative degradation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Can this product be used alongside prescription tretinoin or topical retinoids?\u003c\/strong\u003e\u003cbr\u003eA: Yes. Resveratrol B E is applied post-cleansing in the evening; when co-prescribed with retinoids, it is typically applied before the retinoid, with a 1–2 minute absorption interval. The formulation's absence of fragrance, alcohol denat., and parabens reduces sensitisation risk in patients on active retinoid therapy. If significant retinoid-associated erythema or desquamation is present, clinician assessment should guide sequencing.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: How does Resveratrol B E differ from SkinCeuticals C E Ferulic?\u003c\/strong\u003e\u003cbr\u003eA: SkinCeuticals C E Ferulic is a daytime antioxidant serum containing L-ascorbic acid (15%), alpha-tocopherol (1%), and ferulic acid (0.5%), optimised for photoprotective antioxidant defence under UV exposure and SPF. Resveratrol B E is formulated for nighttime use without photosensitive ascorbic acid, targeting the circadian repair phase. The two formulations address complementary time-of-day antioxidant demands and are prescribed together as morning and evening components of a 24-hour antioxidant protocol.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Is Resveratrol B E suitable for Singapore's tropical climate and skin types?\u003c\/strong\u003e\u003cbr\u003eA: Yes. The lightweight serum texture is appropriate for high-humidity, equatorial conditions and is non-comedogenic. It is compatible with the full range of Fitzpatrick phototypes commonly encountered in Singapore's multi-ethnic population. Storage at room temperature (24–27°C typical in Singapore) is within the product's stability specification; refrigeration is not required. Patients in Singapore experiencing high daily UV exposure (UV Index 11–14) particularly benefit from dual daytime and nighttime antioxidant therapy.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: How does EMIS supply SkinCeuticals Resveratrol B E to clinics?\u003c\/strong\u003e\u003cbr\u003eA: EMIS Singapore supplies SkinCeuticals Resveratrol B E to dermatology clinics, aesthetic medical centres, and hospital pharmacy departments. Products are supplied as HSA-notified cosmetic products under the ASEAN Cosmetic Directive and Health Products Act (Cap. 122D). Bulk pricing, minimum order quantities, clinical protocol resources, and product training are available upon institutional enquiry via the EMIS procurement team.\u003c\/p\u003e\n\n\u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"FAQPage\",\n  \"mainEntity\": [\n    {\n      \"@type\": \"Question\",\n      \"name\": \"What are the benefits of SkinCeuticals Resveratrol B E — Advanced Nighttime Antioxidant Serum for Firm, Radiant, Youthful Ski for digestive health?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"SkinCeuticals Resveratrol B E — Advanced Nighttime Antioxidant Serum for Firm, Radiant, Youthful Ski by SkinCeuticals supports digestive health and gut wellbeing. For individuals with digestive concerns such as IBS, bloating, or irregular bowel habits, targeted gut health supplementation may complement a balanced diet and lifestyle. Always consult a doctor or dietitian before starting supplements for digestive conditions.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Who should take SkinCeuticals Resveratrol B E — Advanced Nighttime Antioxidant Serum for Firm, Radiant, Youthful Ski?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"SkinCeuticals Resveratrol B E — Advanced Nighttime Antioxidant Serum for Firm, Radiant, Youthful Ski may benefit adults seeking to support digestive health, those recovering from antibiotic use, individuals with irregular bowel habits, or those with conditions affecting gut microbiome balance. It is not a substitute for medical treatment. Consult your GP or gastroenterologist — available at SGH, NUH, Mount Elizabeth, and Raffles Hospital in Singapore — for personalised advice.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"How should I take SkinCeuticals Resveratrol B E — Advanced Nighttime Antioxidant Serum for Firm, Radiant, Youthful Ski for best results?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Follow the dosage instructions on the SkinCeuticals Resveratrol B E — Advanced Nighttime Antioxidant Serum for Firm, Radiant, Youthful Ski packaging or as directed by your healthcare provider. Consistency is key — most gut health supplements take 4–8 weeks of regular use to show measurable benefits. Store as directed on the label. Do not exceed the recommended daily dose.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Where can I buy SkinCeuticals Resveratrol B E — Advanced Nighttime Antioxidant Serum for Firm, Radiant, Youthful Ski in Singapore?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"SkinCeuticals Resveratrol B E — Advanced Nighttime Antioxidant Serum for Firm, Radiant, Youthful Ski is available at EMIS+ (emis.asia) with fast Singapore island-wide delivery. We carry a curated range of clinically-informed digestive health supplements. Visit emis.asia or contact our team for product recommendations.\"\n      }\n    }\n  ]\n}\n\u003c\/script\u003e","brand":"SkinCeuticals","offers":[{"title":"Default Title","offer_id":43041847607374,"sku":"3606000498747","price":285.0,"currency_code":"SGD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0613\/3763\/2846\/files\/SkinCeuticals_Resveratrol_B_E.png?v=1767127144","url":"https:\/\/www.emis.asia\/zh\/products\/resveratrol-b-e","provider":"EMIS +","version":"1.0","type":"link"}