{"product_id":"silymarin-cf-30ml","title":"SkinCeuticals Silymarin CF Vitamin C Serum — Oil Free Antioxidant Protection for Clear, Radiant, Blemish Prone Skin","description":"\u003cdiv style=\"background: #f8f9fa; border-left: 4px solid #0057a8; padding: 12px 16px; margin-bottom: 20px;\" id=\"ai-summary\"\u003e\n\u003cstrong\u003eClinical Summary:\u003c\/strong\u003e SkinCeuticals Silymarin CF is a dual-function antioxidant serum formulated specifically for oily and acne-prone skin, combining 15% L-ascorbic acid, 0.5% silymarin (milk thistle flavonolignan complex), 0.5% ferulic acid, and 0.5% salicylic acid in a lightweight, oil-free aqueous delivery system at pH 2.2–3.5. Silymarin reduces sebum oxidation by 76% and suppresses NF-κB-mediated pro-inflammatory mediators (COX-2, TNF, IL-1), while salicylic acid exerts comedolytic and mild keratolytic effects via pilosebaceous unit penetration. Indicated for oily skin with enlarged pores, comedonal acne, post-acne hyperpigmentation, and photoaging in patients for whom the standard C E Ferulic formulation is unsuitable due to skin type or tolerance.\u003c\/div\u003e\n\u003ch2\u003eProduct Overview\u003c\/h2\u003e\n\u003cp\u003eSkinCeuticals Silymarin CF is the oily-skin counterpart to C E Ferulic, engineered to address the specific oxidative and inflammatory burden of seborrheic and acne-prone skin phenotypes. Silymarin, the principal flavonolignan complex extracted from Silybum marianum (milk thistle), provides potent antioxidant activity alongside documented sebostatic and anti-inflammatory properties. Unlike C E Ferulic, which pairs L-ascorbic acid with alpha tocopherol (vitamin E) — itself a potential comedogen in oily skin — Silymarin CF substitutes vitamin E with silymarin and adds 0.5% salicylic acid, a lipid-soluble beta-hydroxy acid that penetrates the pilosebaceous unit to exert comedolytic effects at concentrations above 0.1%. The formula is classified as an oil-free, lightweight serum and is compatible with acne management protocols.\u003c\/p\u003e\n\u003cp\u003eThe antioxidant framework functions as follows: L-ascorbic acid (15%) provides primary radical scavenging and collagen synthesis support via prolyl and lysyl hydroxylase enzyme cofactor activity; ferulic acid (0.5%) stabilises both L-ascorbic acid and silymarin against photodegradation while contributing independent phenolic antioxidant activity — achieving greater than 90% stability for L-ascorbic acid in formulation; silymarin (0.5%) reduces sebum oxidation and suppresses transcription factor NF-κB, thereby downregulating downstream pro-inflammatory mediators including COX-2, lipoxygenase (LOX), inducible nitric oxide synthase (iNOS), TNF-alpha, and IL-1, mechanisms relevant to inflammatory acne pathogenesis. In peer-reviewed clinical study, a silymarin-containing antioxidant serum achieved statistically significant reductions in inflammatory and non-inflammatory acne lesion counts at 12 weeks compared to vehicle control.\u003c\/p\u003e\n\u003ch2\u003eSpecifications\u003c\/h2\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eBrand\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eSkinCeuticals\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eProduct Name\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eSilymarin CF Oil-Free Antioxidant Serum\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eKey Actives\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eL-Ascorbic Acid 15%, Silymarin 0.5%, Ferulic Acid 0.5%, Salicylic Acid 0.5%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eFormulation pH\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e2.2–3.5 (aqueous, acidic, oil-free)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eVolume\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e30 mL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eTarget Skin Type\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eOily, acne-prone, blemish-prone; contraindicated in dry or sensitive skin without tolerance testing\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eApplication Frequency\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eOnce daily (morning), after cleansing, before moisturiser and SPF\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eDose per Application\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e4–5 drops distributed across face, neck, and décolletage\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eRegulatory (Singapore)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eClassified as cosmetic product under Singapore Health Products Act (Cap. 122D) and ASEAN Cosmetic Directive Regulations 2007; HSA notification required prior to supply\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eKey Clinical Evidence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eSilymarin at 0.5%: 76% reduction in sebum oxidation; 25% greater reduction in inflammatory lesions vs. vehicle at 12 weeks; NF-κB inhibition documented in peer-reviewed literature\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eStore below 25°C, away from direct sunlight and air; discard if solution changes colour from pale yellow to orange or brown\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eCountry of Origin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eUnited States\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch2\u003eKey Applications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOily and seborrheic skin antioxidant maintenance:\u003c\/strong\u003e Daily topical antioxidant protection for patients with chronic seborrhoea, providing UV and pollution defence without occlusive emollients or comedogenic excipients.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eComedonal and inflammatory acne adjunct:\u003c\/strong\u003e Salicylic acid at 0.5% penetrates pilosebaceous units and promotes individual corneocyte desquamation, reducing open comedone burden (11% greater reduction vs. vehicle) and inflammatory lesion count (25% greater reduction vs. vehicle at 12 weeks); used alongside topical retinoids or benzoyl peroxide under dermatologist supervision.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePost-acne hyperpigmentation management:\u003c\/strong\u003e L-ascorbic acid inhibits tyrosinase, reducing melanin synthesis at post-inflammatory hyperpigmentation sites; used adjunctively with niacinamide or prescription hydroquinone regimens.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePre- and post-procedure antioxidant support for acne-prone patients:\u003c\/strong\u003e Applied before and after laser, light-based, and chemical peel procedures targeting acne or oily skin to reduce procedural oxidative stress and support wound healing without exacerbating comedonal occlusion.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePhotoprotection augmentation in high-UV environments:\u003c\/strong\u003e Ferulic acid stabilisation doubles the photoprotective efficacy of the vitamin C and silymarin combination; applied before SPF 30+ for comprehensive oxidative and UV defence in Singapore's high-irradiance equatorial climate.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eQ: How does Silymarin CF differ from C E Ferulic, and how should a clinician select between them?\u003c\/strong\u003e\u003cbr\u003eA: Silymarin CF targets oily and acne-prone skin phenotypes: it substitutes alpha tocopherol (vitamin E) — which may be comedogenic at higher concentrations — with silymarin and adds 0.5% salicylic acid for pilosebaceous penetration and comedolysis. C E Ferulic (15% L-ascorbic acid, 1% alpha tocopherol, 0.5% ferulic acid) is formulated for normal, dry, and sensitive skin, with a broader photoprotection data set from Duke University. Clinicians should select Silymarin CF for patients with active seborrhoea, acne, enlarged pores, or vitamin E intolerance, and C E Ferulic for photoaged, normal-to-dry skin.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Is salicylic acid at 0.5% safe for daily morning use alongside prescription acne treatments?\u003c\/strong\u003e\u003cbr\u003eA: At 0.5%, salicylic acid exerts mild comedolytic activity with a low irritation profile suitable for daily use. However, concurrent use with topical retinoids (tretinoin, adapalene), benzoyl peroxide, or alpha-hydroxy acid (AHA) exfoliants may cumulatively increase barrier disruption and erythema, particularly in humid climates such as Singapore. Clinicians and aesthetic practitioners should advise patients to introduce Silymarin CF gradually and monitor for signs of barrier compromise before layering with other active ingredients.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Is Silymarin CF compatible with acne prescription regimens including oral isotretinoin?\u003c\/strong\u003e\u003cbr\u003eA: During oral isotretinoin therapy, the sebaceous glands are pharmacologically suppressed, significantly reducing oiliness. In this context, Silymarin CF (formulated for oily skin) may cause relative dryness; patients on isotretinoin may be better served by C E Ferulic or a less active topical antioxidant. Post-isotretinoin, as sebaceous activity normalises, Silymarin CF may be re-introduced. All decisions should be guided by the prescribing dermatologist's protocol, as isotretinoin-associated mucocutaneous fragility can alter topical tolerability.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: How is this product regulated and authenticated in Singapore?\u003c\/strong\u003e\u003cbr\u003eA: SkinCeuticals Silymarin CF is classified as a cosmetic product under the Singapore Health Products Act (Cap. 122D) and the Health Products (Cosmetic Products — ASEAN Cosmetic Directive) Regulations 2007, administered by the Health Sciences Authority (HSA). EMIS sources product through authorised distributor channels; authentication via lot number traceability is available on request. Clinics and aesthetic practices should retain purchase documentation and be aware that HSA may request cosmetic notification records during market surveillance activities.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: How should the product be stored and what are the signs of degradation?\u003c\/strong\u003e\u003cbr\u003eA: Store below 25°C, away from direct sunlight, heat, and air exposure. L-ascorbic acid undergoes progressive oxidation; colour change from pale straw-yellow to orange or brown indicates significant oxidative degradation. A brown formulation delivers substantially reduced antioxidant activity and should be discarded. Ferulic acid at 0.5% extends formulation stability; however, storage compliance remains critical. Opened product should ideally be used within 3–6 months.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eAvailable in Singapore from EMIS (Essential Medical International Supplies Pte Ltd). For professional procurement or clinic stock enquiries, contact our B2B team at emis.asia.\u003c\/em\u003e\u003c\/p\u003e\n\n\u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"FAQPage\",\n  \"mainEntity\": [\n    {\n      \"@type\": \"Question\",\n      \"name\": \"What is SkinCeuticals Silymarin CF Vitamin C Serum — Oil Free Antioxidant Protection for Clear, Radiant, Ble used for?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"SkinCeuticals Silymarin CF Vitamin C Serum — Oil Free Antioxidant Protection for Clear, Radiant, Ble by SkinCeuticals is a antimicrobial silver dressing used for wound management. It is designed to support moist wound healing, manage exudate, and protect the wound bed from contamination. It is commonly used in Singapore hospitals and home care settings for chronic wounds, post-surgical wounds, and ulcers. Always follow the guidance of your wound care nurse or doctor when selecting a dressing.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"How often should SkinCeuticals Silymarin CF Vitamin C Serum — Oil Free Antioxidant Protection for Clear, Radiant, Ble be changed?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"SkinCeuticals Silymarin CF Vitamin C Serum — Oil Free Antioxidant Protection for Clear, Radiant, Ble should generally be changed every 2–7 days depending on wound condition. However, frequency should always be guided by your wound care nurse or clinician based on wound size, exudate level, and signs of infection. Do not leave any dressing in place if it becomes saturated, dislodged, or if the wound shows signs of infection such as increased redness, warmth, or discharge.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Is SkinCeuticals Silymarin CF Vitamin C Serum — Oil Free Antioxidant Protection for Clear, Radiant, Ble available without prescription in Singapore?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Yes, SkinCeuticals Silymarin CF Vitamin C Serum — Oil Free Antioxidant Protection for Clear, Radiant, Ble is available for purchase from EMIS+ (emis.asia) without a prescription for general wound care use. For complex or chronic wounds, we strongly recommend consulting a wound care nurse, GP, or specialist at a Singapore hospital such as SGH, NUH, TTSH, or CGH before selecting a dressing. EMIS+ nurses can also provide product guidance — contact us at emis.asia\/pages\/contact.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Where can I buy SkinCeuticals Silymarin CF Vitamin C Serum — Oil Free Antioxidant Protection for Clear, Radiant, Ble in Singapore?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"SkinCeuticals Silymarin CF Vitamin C Serum — Oil Free Antioxidant Protection for Clear, Radiant, Ble is available from EMIS+ at emis.asia, Singapore's nurse-led medical supply store. We offer fast island-wide delivery, competitive pricing, and bulk ordering for healthcare facilities and home care users. Visit emis.asia or contact our team for assistance.\"\n      }\n    }\n  ]\n}\n\u003c\/script\u003e","brand":"SkinCeuticals","offers":[{"title":"Default Title","offer_id":43041847803982,"sku":"3337875746267","price":285.0,"currency_code":"SGD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0613\/3763\/2846\/files\/SkinCeuticals_Silymarin_CF_Vitamin_C_Serum.png?v=1767127019","url":"https:\/\/www.emis.asia\/zh\/products\/silymarin-cf-30ml","provider":"EMIS +","version":"1.0","type":"link"}