Dr Berg
Dr. Berg Adrenal & Cortisol Support - Premium Stress Relief Formula
Dr. Berg Adrenal & Cortisol Support - Premium Stress Relief Formula
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Product Overview
Dr. Berg Adrenal & Cortisol Support addresses dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis — the central neuroendocrine pathway governing cortisol secretion in response to physiological and psychological stress. Chronic HPA axis activation leads to persistently elevated cortisol, with downstream consequences including immune suppression, hippocampal atrophy, insulin resistance, and disrupted sleep architecture. The formula combines evidence-reviewed adaptogenic botanicals with targeted micronutrients to support adrenal steroidogenesis, attenuate cortisol peak amplitude, and facilitate HPA axis negative feedback.
Ashwagandha root extract (Withania somnifera) is the primary adaptogen, with published randomised controlled trial data demonstrating statistically significant reductions in serum cortisol (Chandrasekhar et al., 2012, JAPI) and self-reported stress scores versus placebo. Rhodiola rosea contributes anti-fatigue and neuroprotective properties mediated via monoamine oxidase (MAO) inhibition and HPA axis modulation. Holy basil (Ocimum tenuiflorum) provides eugenol and rosmarinic acid constituents with anti-inflammatory and cortisol-lowering bioactivity. The micronutrient component addresses adrenal-specific depletion patterns: vitamin C is essential for cortisol biosynthesis, and adrenal glands maintain the highest vitamin C concentration of any tissue in the body. Chromium polynicotinate supports glycaemic regulation downstream of cortisol-induced hepatic glucose output. The formula is vegan, keto-compatible, and produced in a US cGMP-certified facility.
Supplement Facts
| Manufacturer | Dr. Eric Berg DC / KB Wellness LLC, USA |
|---|---|
| Format | 60 vegetable capsules; 60 servings (1 capsule per day) |
| Key Adaptogens | Ashwagandha root extract (Withania somnifera), Rhodiola rosea root powder, holy basil leaf extract (Ocimum tenuiflorum), rehmannia powder |
| Vitamin C | As magnesium ascorbate and zinc ascorbate (buffered, non-acidic form) |
| Selenium | 25 mcg as L-selenomethionine |
| Chromium | 100 mcg as chromium polynicotinate |
| Additional Nutrients | Magnesium (as magnesium ascorbate), zinc (as zinc ascorbate), manganese (as manganese citrate), nutritional yeast, camu camu powder |
| Manufacturing Standard | cGMP-certified facility (USA); vegan; keto-compatible; non-GMO |
| Regulatory Status (SG) | Health supplement under HSA Health Products Act (HPA) Cap 122D; adaptogens are permitted botanical ingredients per HSA health supplement guidelines |
| Dosage | 1 capsule per day with or without food; best taken in the morning to align with circadian cortisol peak |
Clinical Indications and Key Applications
- HPA axis dysregulation presenting as chronic stress-related fatigue, morning cortisol blunting, or elevated evening cortisol on salivary cortisol testing — adjunctive support alongside lifestyle and behavioural interventions per Singapore MOH mental wellness guidelines
- Occupational burnout with physiological correlates: elevated serum cortisol, disrupted DHEA:cortisol ratio, or adrenal insufficiency staging on functional medicine evaluation
- Post-viral fatigue states where adrenal axis recovery is impaired and adaptogenic support is employed as part of a supervised functional recovery protocol
- Glycaemic dysregulation in cortisol-dominant metabolic profiles, where chromium polynicotinate supplementation may assist insulin sensitivity as an adjunct to dietary modification
- Integrative psychiatry and primary care applications in Singapore for patients managed for anxiety, insomnia, or generalised fatigue who decline or are contraindicated to pharmaceutical anxiolytics
Frequently Asked Questions
Q: What is the evidence base for ashwagandha in cortisol reduction?
A double-blind, placebo-controlled RCT by Chandrasekhar et al. (2012, Indian Journal of Psychological Medicine) demonstrated a 27.9% reduction in serum cortisol and significant improvements in Perceived Stress Scale scores versus placebo in adults with chronic stress. A meta-analysis by Pratte et al. (2014, Journal of Alternative and Complementary Medicine) further supports ashwagandha's adaptogenic efficacy. Standardised KSM-66 and Sensoril extract forms have the most robust clinical datasets.
Q: Does ashwagandha interact with thyroid medications?
Ashwagandha has demonstrated thyroid-stimulating activity in some clinical studies, potentially elevating T3 and T4 levels. Patients on levothyroxine (e.g., Eltroxin) or antithyroid medications should have thyroid function tests monitored if commencing ashwagandha supplementation, and should consult their endocrinologist or GP before use.
Q: Is this product appropriate for pregnant or breastfeeding women?
Ashwagandha is contraindicated in pregnancy due to its traditional use as a uterine stimulant and insufficient safety data in human trials. Pregnant and breastfeeding women should not use this product without explicit medical supervision.
Q: Can this product be taken alongside prescribed anxiolytics or antidepressants?
Rhodiola rosea exhibits mild MAO-inhibiting activity; concurrent use with MAO inhibitor (MAOI) antidepressants is contraindicated. Patients on SSRIs, SNRIs, or benzodiazepines should consult their psychiatrist or GP before adding adaptogenic supplements to their regimen due to potential pharmacodynamic interactions.
Q: How is this product regulated in Singapore?
Sold as a health supplement under the HSA Health Products Act (HPA) Chapter 122D. Ashwagandha, Rhodiola, and holy basil are permitted botanical ingredients in Singapore health supplements. The product must comply with HSA labelling requirements including permitted claims and prohibited therapeutic claim restrictions.
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