SkinCeuticals A.G.E. Interrupter Advanced

Product Overview

SkinCeuticals A.G.E. Interrupter Advanced (Code S117, 48 ml / 1.7 fl oz) is a corrective treatment cream developed to counter the visible cutaneous consequences of glycation, the non-enzymatic binding of sugars to dermal proteins that produces Advanced Glycation End-products (A.G.E.s) and contributes to collagen cross-linking, loss of elasticity, sallow tone, and deep wrinkle formation in mature skin. The reformulated 2023 advanced version retains the brand's hallmark glycation-targeting strategy while increasing Proxylane concentration to 18 percent — reported by SkinCeuticals to deliver six times the minimum dose required to stimulate glycosaminoglycan (GAG) synthesis and support type VII collagen.

The formula combines this Proxylane core with a 4.25 percent wild fruit flavonoid complex of blueberry and pomegranate extracts, which act as broad-spectrum antioxidants that inhibit protein glycation including UV-induced glycation cascades, and 0.1 percent glycyrrhetinic acid (a licorice-derived anti-inflammatory) to address the dull, sallow tone associated with chronic A.G.E. accumulation. The cream is intended for daily PM application on mature skin with established wrinkles, crepiness, and laxity, and is suitable for use under standard SkinCeuticals corrective and protective regimens.

Specifications

Clinical Indications

• Visible photoageing with established forehead lines, glabellar wrinkles, nasolabial folds, marionette lines, and crow's feet
• Loss of skin firmness and elasticity associated with chronic glycation in patients aged 40 and above
• Adjunct topical maintenance after in-clinic anti-ageing procedures (laser resurfacing, microneedling, dermal filler, botulinum toxin) once skin barrier is restored
• Sallow, dull complexion linked to A.G.E. accumulation and oxidative stress
• Diabetic and pre-diabetic patient skin where accelerated glycation pathways are clinically relevant
• Post-menopausal skin where oestrogen-related collagen decline compounds glycation damage

Frequently Asked Questions

How is A.G.E. Interrupter Advanced different from the original A.G.E. Interrupter?

The original A.G.E. Interrupter (S02) has been discontinued by SkinCeuticals globally and replaced by A.G.E. Interrupter Advanced (S117). The Advanced formulation increases the Proxylane concentration from 30 percent (in a different delivery system) to a clinically optimised 18 percent in a richer cream base, adds the wild fruit flavonoid blend at 4.25 percent for stronger antioxidant and anti-glycation defence, and incorporates glycyrrhetinic acid for tone improvement. The Advanced product is supplied in a 48 ml airless pump versus the original 50 ml tube.

Where in the skincare routine should this product be applied?

SkinCeuticals positions A.G.E. Interrupter Advanced as a PM corrective. The recommended evening sequence is: cleanser, antioxidant or treatment serum (e.g. Resveratrol B E or H.A. Intensifier), A.G.E. Interrupter Advanced, then optional retinol for tolerant skin. In the morning, follow with a vitamin C antioxidant (such as C E Ferulic) and broad-spectrum SPF 30 or higher, as glycation damage is amplified by UV exposure.

Is the product safe for sensitive or post-procedure skin?

The formulation is fragrance-free, paraben-free, and non-comedogenic, and is generally well tolerated. Patch testing is advisable for very sensitive or rosacea-prone skin. Use should be deferred until the skin barrier is fully restored after ablative resurfacing, deep peels, or microneedling — typically 5-7 days post-procedure or as directed by the supervising aesthetic clinician.

Is this product registered with the Singapore HSA?

SkinCeuticals products are notified to the Health Sciences Authority (HSA) of Singapore under the ASEAN Cosmetic Directive (ACD) framework as required for legal cosmetic supply. EMIS+ procures all SkinCeuticals stock through the authorised regional distributor, ensuring batch traceability and compliance with HSA labelling and ingredient disclosure requirements.

How quickly should results be visible?

SkinCeuticals' clinical studies on A.G.E. Interrupter Advanced report measurable smoothing of wrinkle depth in five facial zones at 12 weeks of consistent nightly use. Patients should be counselled that anti-glycation activity is preventative as well as corrective, and that combined use with daily SPF and topical antioxidants produces the most reproducible outcomes.