Bbraun
B Braun Hartmanns Solution Compound Sodium Lactate 500ml and 1000ml 10 Bottles
B Braun Hartmanns Solution Compound Sodium Lactate 500ml and 1000ml 10 Bottles
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Product Overview
B. Braun Hartmann's Solution is a pharmacopoeia-grade compound sodium lactate intravenous infusion manufactured to British Pharmacopoeia (BP) and European Pharmacopoeia (EP) standards. As a balanced crystalloid solution, its electrolyte composition is formulated to closely approximate the ionic content of extracellular fluid, making it physiologically appropriate for volume replacement without inducing hyperchloraemic metabolic acidosis — a recognised limitation of normal saline (0.9% sodium chloride) infusion in large volumes.
The solution is supplied in Ecoflac Plus polyethylene bottles with integrated hangers, designed for direct connection to standard IV administration sets without requiring additional spike preparation. The lactate component serves as a bicarbonate precursor, undergoing hepatic metabolism to generate bicarbonate ions that contribute to acid-base correction in patients with mild to moderate metabolic acidosis. B. Braun manufactures this product under cGMP conditions at ISO 13485-certified facilities with full traceability from raw material to finished product.
Specifications
| Manufacturer | B. Braun Melsungen AG (Melsungen, Germany) / B. Braun Medical Industries (Penang, Malaysia) |
| Product | Compound Sodium Lactate Intravenous Infusion BP (Hartmann's Solution) |
| Sodium Lactate | 3.17 g/L (sodium 131 mmol/L, lactate 29 mmol/L) |
| Sodium Chloride | 6.0 g/L (chloride 111 mmol/L) |
| Potassium Chloride | 0.4 g/L (potassium 5 mmol/L) |
| Calcium Chloride Dihydrate | 0.27 g/L (calcium 2 mmol/L) |
| Theoretical Osmolarity | Approximately 278 mOsmol/L (slightly hypotonic) |
| pH Range | 5.0 – 7.0 |
| Appearance | Clear, colourless solution |
| Sterility | Sterile, pyrogen-free; terminally sterilised by autoclaving |
| Container | Ecoflac Plus polyethylene bottle with integrated hanger |
| Available Volumes | 500 mL and 1000 mL |
| Packaging | 10 bottles per carton |
| Shelf Life | 3 years from date of manufacture (unopened) |
| Latex Content | Latex-free |
| Regulatory | HSA Singapore registered; CE marked; manufactured under ISO 13485 and cGMP; compliant with BP and EP monographs |
Clinical Indications and Key Applications
- Replacement of extracellular fluid volume losses in isotonic dehydration due to surgical fluid losses, gastrointestinal losses (vomiting, diarrhoea, fistula output), or third-space sequestration
- Perioperative intravenous fluid therapy for maintenance and replacement during general, regional, and local anaesthesia procedures
- Fluid resuscitation in burn injury management for initial volume replacement during the first 24–48 hours per established burn formulae (e.g., Parkland formula)
- Correction of mild to moderate metabolic acidosis via lactate-to-bicarbonate hepatic conversion
- Vehicle for dilution and intravenous administration of compatible medications where electrolyte-balanced diluent is required
- Trauma and emergency department fluid resuscitation as a balanced crystalloid alternative to normal saline
Frequently Asked Questions
Q: What is the clinical advantage of Hartmann's Solution over normal saline (0.9% NaCl)?
A: Hartmann's Solution provides a balanced electrolyte profile that more closely approximates extracellular fluid composition. Large-volume infusion of normal saline delivers a supraphysiological chloride load (154 mmol/L vs. plasma 96–106 mmol/L), which can induce hyperchloraemic metabolic acidosis and renal vasoconstriction. The SMART trial (Semler et al., NEJM 2018) demonstrated that balanced crystalloids, including Hartmann's Solution, were associated with lower rates of major adverse kidney events compared with normal saline in critically ill patients.
Q: Are there contraindications to using Hartmann's Solution?
A: Hartmann's Solution should be used with caution in patients with severe hepatic impairment (as lactate metabolism may be compromised), hyperkalaemia (the solution contains 5 mmol/L potassium), and hypercalcaemia. It should not be administered concurrently with citrated blood products through the same IV line, as calcium ions can chelate with citrate anticoagulant and promote clot formation. It is also not recommended for patients with severe metabolic alkalosis.
Q: What is the recommended infusion rate for Hartmann's Solution?
A: Infusion rate depends on clinical indication, patient weight, age, and haemodynamic status. General adult maintenance rates are typically 1–2 mL/kg/hour. For perioperative replacement, rates of 5–10 mL/kg/hour may be used during active surgical losses. In burn resuscitation, the Parkland formula (4 mL × body weight in kg × %TBSA burn) guides total 24-hour volume. Infusion should be monitored with clinical assessment and, where available, haemodynamic monitoring to avoid fluid overload.
Q: Can Hartmann's Solution be used to dilute intravenous medications?
A: Hartmann's Solution can serve as a diluent for many compatible IV medications. However, compatibility must be confirmed for each drug, as the calcium and potassium content may interact with certain medications (e.g., ceftriaxone is incompatible with calcium-containing solutions). Always consult the drug manufacturer's compatibility data or a clinical pharmacist before admixture.
Q: Where can I purchase B. Braun Hartmann's Solution in Singapore?
A: B. Braun Hartmann's Solution (Compound Sodium Lactate) is available in Singapore through EMIS (Essential Medical International Supplies Pte Ltd). The product is HSA-registered and available in 500 mL and 1000 mL Ecoflac Plus bottles, supplied in cartons of 10. Orders can be placed through emis.asia for healthcare facility procurement and individual clinical use.
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