Science Research Wellness: SRW
SRW Cel¹ Cellular Stability & DNA Support
SRW Cel¹ Cellular Stability & DNA Support
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Product Overview
SRW Cel¹ Stability is the foundational product in the Science Research Wellness Cel System, a three-part longevity nutraceutical range developed in New Zealand. Cel¹ addresses genomic instability — recognised as a primary hallmark of ageing by López-Otín et al. (Cell, 2013; updated 2023) — through a targeted combination of compounds that protect DNA integrity, support telomere maintenance, and reinforce cellular defences against oxidative and environmental damage.
The formulation’s centrepiece, 2-HOBA (Hobamine™), is a compound derived from Himalayan Tartary Buckwheat that selectively neutralises isolevuglandins — highly reactive dicarbonyl compounds generated during lipid peroxidation that can form irreversible adducts with DNA, proteins, and phospholipids. Unlike conventional antioxidants, 2-HOBA targets these specific reactive intermediates without interfering with protective prostaglandin and thromboxane signalling pathways. Astragaloside IV, extracted from Astragalus membranaceus root, supports telomerase activity, the enzyme responsible for maintaining telomere length at chromosomal termini. The SRW Cel System has been evaluated in a peer-reviewed 12-month clinical trial published in Frontiers in Aging (2024).
Specifications
| Manufacturer | SRW Laboratories (Science Research Wellness), New Zealand |
| Product Code | Cel¹ Stability |
| Key Active: 2-HOBA | Hobamine™ (2-hydroxybenzylamine) — selective isolevuglandin scavenger for DNA and protein protection |
| Key Active: Astragaloside IV | Astragalus membranaceus extract — telomerase activity support for telomere length maintenance |
| Key Active: Rutin | Sophora japonica extract — flavonoid glycoside for oxidative stress neutralisation and cellular resilience |
| Cofactors | Vitamin C, Levomefolic Acid (5-MTHF), Vitamin B12 (methylcobalamin), Zinc, Selenium |
| Capsule Type | Vegetarian capsule (60 per bottle) |
| Dosage | 2 capsules daily with food, or as directed by healthcare practitioner |
| Manufacturing Standard | GMP-certified facility; ISO 22000 Food Safety Management compliant |
| Regulatory Status | Listed dietary supplement (New Zealand MPI); compliant with Singapore HSA Health Supplement guidelines |
| Clinical Evidence | 12-month single-arm clinical trial (Frontiers in Aging, 2024; PMC11984428) |
| Allergens | Free from gluten, dairy, soy, and artificial colours |
Clinical Indications and Key Applications
- Genomic stability support for adults aged 30 and above experiencing age-related accumulation of oxidative DNA damage and telomere attrition
- Targeted isolevuglandin scavenging for individuals with elevated oxidative stress markers or chronic inflammatory conditions
- Telomere maintenance support via astragaloside IV for individuals seeking to preserve replicative capacity of stem and progenitor cells
- Cellular resilience reinforcement against environmental stressors including UV radiation, atmospheric pollution, and chronic psychological stress
- Methylation cycle support via 5-MTHF and methylcobalamin for individuals with MTHFR polymorphisms or suboptimal folate status
- Foundational component of the SRW Cel System longevity protocol alongside Cel² Nourishment and Cel³ Renewal
Frequently Asked Questions
Q: What is 2-HOBA and how does it differ from conventional antioxidants?
A: 2-HOBA (2-hydroxybenzylamine), marketed as Hobamine™, is a naturally occurring amine found in Himalayan Tartary Buckwheat. Unlike broad-spectrum antioxidants such as vitamin C or E, 2-HOBA selectively neutralises isolevuglandins (isoLGs) — highly reactive gamma-ketoaldehyde compounds produced during lipid peroxidation. IsoLGs form irreversible covalent adducts with DNA, proteins, and phospholipids within milliseconds of formation. By specifically targeting these compounds, 2-HOBA provides DNA protection without suppressing beneficial reactive oxygen species signalling involved in immune function and cellular communication.
Q: How does astragaloside IV support telomere length?
A: Astragaloside IV, a saponin isolated from Astragalus membranaceus root, has been shown in published in vitro and animal studies to upregulate telomerase activity — the ribonucleoprotein enzyme that adds TTAGGG hexanucleotide repeats to chromosomal telomere ends. Progressive telomere shortening with each cell division is a well-established hallmark of cellular ageing. Supporting telomerase activity may help maintain telomere length and preserve the replicative lifespan of stem cells and immune progenitor cells.
Q: Why does the formulation include methylated B vitamins?
A: Levomefolic acid (5-MTHF) and methylcobalamin (active B12) are included to support one-carbon metabolism and the methylation cycle, which is critical for DNA repair, epigenetic gene regulation, and homocysteine metabolism. Approximately 10–15% of the population carries MTHFR C677T polymorphisms that reduce conversion of folic acid to its active form. Using pre-methylated forms ensures bioavailability regardless of MTHFR genotype status.
Q: Is Cel¹ registered with Singapore health authorities?
A: SRW Cel¹ Stability is manufactured in a GMP-certified, ISO 22000-compliant facility in New Zealand and complies with Singapore Health Sciences Authority (HSA) guidelines for health supplements. As a dietary supplement, it does not require HSA pre-market approval. It is imported and distributed by EMIS Pte Ltd in accordance with Singapore Food Agency (SFA) import regulations.
Q: Can Cel¹ be taken concurrently with anticoagulant medications?
A: Rutin has mild documented effects on platelet aggregation, and vitamin C at supplemental doses may theoretically interact with warfarin metabolism. Individuals taking anticoagulants (warfarin, DOACs), antiplatelet agents, or preparing for surgical procedures should consult their prescribing physician before commencing Cel¹ supplementation to assess bleeding risk and adjust monitoring if appropriate.
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