Cir1 Blood Vessel and Circulation Support Supplement for Endothelial Health

Product Overview

SRW Cir¹ addresses the integrity and function of the endothelial glycocalyx, a glycoprotein layer lining the interior of all blood vessels. This structure regulates vascular permeability, prevents platelet adhesion, modulates inflammatory mediators, and enables endothelial nitric oxide synthase (eNOS) activity — the primary driver of vasodilation. Age-related glycocalyx degradation is associated with elevated systemic vascular resistance and impaired endothelial-dependent relaxation, as documented in peer-reviewed cardiovascular research published in journals including Cardiovascular Research and the Journal of the American College of Cardiology.

The formulation combines rhamnan sulphate — a sulphated polysaccharide from green seaweed Monostroma nitidum, structurally analogous to heparan sulphate proteoglycans in the glycocalyx — with L-citrulline for nitric oxide pathway support, HydroCurc® curcumin (patented LipiSperse® delivery) for anti-inflammatory activity, Vitamin K2 (MK-7) for matrix Gla protein activation, and Vitamin D3 for endothelial co-factor support. All actives are encapsulated in delayed-release HPMC vege capsules for enhanced gastrointestinal stability.

Supplement Facts

Clinical Applications

• Endothelial glycocalyx maintenance: Rhamnan sulphate provides sulphated polysaccharide building blocks structurally analogous to heparan sulphate, supporting glycocalyx structural integrity as the body's capacity to synthesise these structures declines with age and metabolic stress.
• Nitric oxide pathway support: L-citrulline is converted to L-arginine in the kidney and used directly by endothelial nitric oxide synthase (eNOS) for NO synthesis; citrulline bypasses hepatic first-pass arginine catabolism, resulting in more sustained plasma arginine elevation than oral L-arginine supplementation.
• Vascular inflammation modulation: HydroCurc® curcumin (85% standardisation) inhibits NF-κB-mediated inflammatory signalling; the LipiSperse® delivery system achieves significantly higher plasma curcumin concentrations than unformulated curcumin, without requiring piperine co-administration.
• Vascular calcification prevention: Vitamin K2 (MK-7) activates matrix Gla protein (MGP), the primary endogenous inhibitor of vascular smooth muscle calcification; MK-7 provides a plasma half-life of approximately 3 days (vs. hours for MK-4), enabling once-daily dosing.
• Preventive cardiovascular supplementation: Suitable for Singapore adults over 40 seeking evidence-based supplementation for long-term cardiometabolic risk reduction alongside physician-supervised lifestyle modification.
• Post-procedure vascular recovery support: May be considered by integrative medicine practitioners to support vascular endothelial recovery after procedures that transiently affect endothelial integrity, such as contrast angiography or intensive aerobic training.

Frequently Asked Questions

Q: What is the endothelial glycocalyx and why is it important for circulatory health?
A: The endothelial glycocalyx is a gel-like layer of glycoproteins and proteoglycans coating the luminal surface of all blood vessel endothelial cells. It functions as a mechanosensor for blood flow shear stress, modulates nitric oxide production, and prevents excessive platelet and leukocyte adhesion. Research published in cardiovascular journals documents that glycocalyx thickness decreases with advancing age, hyperglycaemia, and chronic low-grade inflammation, correlating with increased arterial stiffness and cardiovascular event risk.

Q: How long should SRW Cir¹ be taken before results are expected?
A: Circulatory health supplements targeting glycocalyx structural support and nitric oxide pathway function typically require 8–12 weeks of consistent daily use before measurable changes in vascular function markers (such as flow-mediated dilation) are apparent. SRW Laboratories recommends a minimum 90-day trial period; long-term use alongside a cardioprotective diet and regular aerobic exercise is encouraged for sustained benefit.

Q: Can SRW Cir¹ be taken with antihypertensive or anticoagulant medications?
A: L-citrulline can augment the vasodilatory effect of antihypertensive agents, potentially causing additive blood pressure reduction. Vitamin K2 (MK-7) may reduce the anticoagulant effect of warfarin by supporting clotting factor carboxylation. Individuals on antihypertensives, anticoagulants (warfarin, rivaroxaban), or statins should consult their physician before commencing Cir¹. EMIS Asia recommends medical supervision for supplementation in those with diagnosed cardiovascular conditions.

Q: Is SRW Cir¹ available for procurement by Singapore clinics or hospitals?
A: Yes. EMIS Asia supplies SRW Cir¹ to Singapore healthcare professionals, integrative medicine clinics, and corporate wellness managers. Institutional pricing and standing order arrangements are available. As a health supplement (not a medical device), Cir¹ does not require HSA medical device registration under the Health Products Act (Singapore).

Q: What distinguishes rhamnan sulphate from other vascular supplements such as pine bark extract or resveratrol?
A: Rhamnan sulphate is a sulphated polysaccharide with structural similarity to the heparan sulphate chains that form part of the endothelial glycocalyx — a mechanism distinct from antioxidant-mediated approaches. Pine bark extract (oligomeric proanthocyanidins) and resveratrol act primarily as antioxidants and NF-κB inhibitors, supporting endothelial function through oxidative stress reduction. Cir¹ incorporates HydroCurc® for anti-inflammatory support alongside rhamnan sulphate for a complementary dual-mechanism approach.