Fresenius Kabi Glutamine Plus Orange – High-Glutamine Medical Nutrition Powder with Antioxidants (30 Sachets)

Product Overview

Fresenius Kabi Glutamine Plus Orange is a specialised oral nutritional supplement formulated for patients experiencing elevated glutamine demand due to surgical stress, burns, trauma or chronic inflammatory conditions. Each 22.4 g sachet delivers 10 g of free L-glutamine alongside a targeted antioxidant blend, reconstituted by dissolving in 200 ml of cold or room-temperature water. The orange-flavoured powder is designed for palatable oral consumption as a supplement to regular enteral nutrition.

Glutamine is the most abundant conditionally essential amino acid in the body and serves as a primary fuel source for enterocytes and immune cells. Under catabolic stress, endogenous glutamine production is insufficient to meet demand, leading to mucosal atrophy and compromised immune function. Glutamine Plus addresses this deficit with a clinically relevant dose of free L-glutamine supported by micronutrients that counteract oxidative damage at the cellular level.

Specifications

Clinical Indications

• Pre-operative and post-operative nutritional support to enhance wound healing and reduce infectious complications in elective surgical patients
• Burn injury management where glutamine depletion accelerates muscle catabolism and compromises immune defence
• Trauma patients requiring metabolic support during the acute catabolic phase
• Chronic wound management including diabetic ulcers and pressure injuries with impaired healing trajectories
• Critically ill patients in intensive care settings with documented glutamine depletion, per ESPEN 2019 ICU nutrition guidelines
• Chronic inflammatory conditions such as inflammatory bowel disease where mucosal integrity is compromised

Frequently Asked Questions

What is the clinical rationale for supplementing glutamine in surgical patients?

Glutamine is a conditionally essential amino acid that becomes depleted during catabolic stress. ESPEN guidelines note that plasma glutamine levels fall significantly after major surgery, leading to impaired enterocyte proliferation and reduced lymphocyte function. Supplementation at doses of 20–30 g per day has been associated with shorter hospital stays and reduced infectious complications in multiple randomised controlled trials.

Why does Glutamine Plus include antioxidants alongside L-glutamine?

Surgical stress and tissue injury generate reactive oxygen species that delay wound healing and amplify the inflammatory cascade. The combination of vitamins C and E, beta-carotene, zinc and selenium provides complementary antioxidant protection across both aqueous and lipid compartments. This synergistic formulation aligns with recommendations from the European Wound Management Association (EWMA) for perioperative micronutrient support.

Is Glutamine Plus suitable for tube feeding?

No. Fresenius Kabi specifies that Glutamine Plus is intended for oral administration only and is not recommended for enteral tube feeding. For patients requiring parenteral glutamine supplementation, Fresenius Kabi offers Dipeptiven (L-alanyl-L-glutamine) as an intravenous alternative.

Can this product be used in paediatric patients?

Glutamine Plus is not suitable for children under 10 years of age. Paediatric glutamine supplementation should be discussed with a paediatric dietitian or clinical nutritionist familiar with age-appropriate dosing protocols.

How do I purchase Glutamine Plus for my Singapore clinic or hospital?

Glutamine Plus is available for purchase through EMIS (Essential Medical International Supplies Pte Ltd) for delivery within Singapore. Institutional and bulk pricing is available for hospitals, clinics and long-term care facilities. The product is classified as a Food for Special Medical Purposes and may be procured without a prescription, though clinical supervision of use is recommended per ESPEN guidelines.