Prontosan Antimicrobial Wound Irrigation Solution 40 ml Box of 24

Product Overview

Prontosan Wound Irrigation Solution is an evidence-based wound cleansing agent developed by B. Braun Medical for the irrigation and decontamination of acute and chronic wounds. The formulation combines two synergistic active components: polyhexamethylene biguanide (PHMB) at 0.1% concentration, a broad-spectrum antimicrobial agent, and undecylenamidopropyl betaine at 0.1% concentration, a surfactant that reduces surface tension to penetrate, loosen, and remove wound debris, necrotic tissue, and biofilm from the wound bed. This dual mechanism addresses two critical barriers to wound healing — microbial contamination and biofilm formation.

The 40 ml single-dose ampoule format ensures sterility at point of use and eliminates the risk of cross-contamination associated with multi-use containers. Prontosan is pH-neutral and isotonic, demonstrating excellent tissue compatibility with minimal cytotoxicity to human fibroblasts and keratinocytes. NICE Medical Technologies Guidance (MTG67) has evaluated Prontosan for use in acute and chronic wound management, recognising its role in wound bed preparation and biofilm management strategies as part of comprehensive wound care protocols.

Specifications

Clinical Indications

• Irrigation and cleansing of chronic wounds with suspected or confirmed biofilm, including pressure injuries (Category/Stage II–IV), venous leg ulcers, and diabetic foot ulcers
• Decontamination and wound bed preparation prior to surgical debridement, skin grafting, or application of advanced wound therapies (negative pressure wound therapy, cellular tissue products)
• Post-surgical wound irrigation for contaminated or infected surgical sites, including orthopaedic, abdominal, and dermatological procedures
• Management of partial-thickness and full-thickness burns requiring antimicrobial wound cleansing without cytotoxic effects on regenerating tissue
• Wound irrigation in home care and community nursing settings where single-dose sterile preparation reduces infection control risk

Frequently Asked Questions

How does Prontosan differ from normal saline for wound irrigation?

Normal saline (0.9% NaCl) provides mechanical flushing but has no antimicrobial or anti-biofilm properties. Prontosan combines mechanical cleansing via the betaine surfactant with sustained antimicrobial action from PHMB. The surfactant component specifically targets and disrupts wound biofilm — a significant barrier to healing present in an estimated 60–80% of chronic wounds according to published wound care research. NICE Medical Technologies Guidance (MTG67) has reviewed evidence supporting Prontosan over saline alone for chronic wound management.

Is Prontosan safe for use on all wound types?

Prontosan is indicated for acute and chronic wounds of various aetiologies. However, it should not be used on hyaline cartilage, in the central nervous system, the middle or inner ear, or the eye. It is not recommended for peritoneal lavage. Clinicians should consult the product insert and institutional wound care formulary for contraindications specific to their clinical context.

What is the recommended irrigation technique with the 40 ml ampoule?

The 40 ml ampoule is designed for single-patient, single-use application. The Luer-compatible tip allows direct irrigation of the wound bed or connection to a syringe or irrigation catheter for controlled delivery. B. Braun recommends allowing Prontosan to remain in contact with the wound surface for a minimum of 15 minutes to achieve optimal biofilm disruption and antimicrobial effect. For heavily contaminated wounds, clinicians may soak gauze or wound packing material in Prontosan prior to application.

Can Prontosan be used with other wound dressings?

Yes. Prontosan Wound Irrigation Solution is compatible with standard wound dressings including alginates, foams, hydrofibers, and hydrogels. It is commonly used as a wound bed preparation step before applying primary dressings such as AQUACEL, Kaltostat, or foam-based dressings. The solution can also be used with the Prontosan Wound Gel X for combined irrigation and sustained-release antimicrobial therapy.

Is Prontosan registered for use in Singapore healthcare settings?

Prontosan is CE marked under EU MDR 2017/745 as a Class IIb medical device and manufactured under ISO 13485 quality management systems. It is distributed in Singapore through EMIS (Essential Medical International Supplies Pte Ltd) in compliance with the Health Sciences Authority (HSA) regulatory framework for medical devices. Healthcare facilities can purchase directly via emis.asia with GST-inclusive pricing.