Byra
Rejuvenate Nutri Serum Concentrate for Skin Renewal Hydration and Firmness 30ml
Rejuvenate Nutri Serum Concentrate for Skin Renewal Hydration and Firmness 30ml
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Product Overview
Rejuvenate Nutri-Serum Concentrate is part of the Byra cosmetic skincare range, formulated and bottled to ASEAN Cosmetic Directive Annex II/III compliance for the Singapore market. The serum is positioned as a daily-use treatment in a comprehensive anti-aging routine and complements (rather than replaces) photoprotection. Its principal active, bakuchiol, has been characterised in randomised double-blind studies (Dhaliwal et al., Br J Dermatol 2019) as comparable to retinol 0.5% for improving wrinkle area and hyperpigmentation while producing significantly less scaling and stinging.
The supporting actives address barrier hydration and biome-friendly skin function: hyaluronic acid (a glycosaminoglycan) holds water within the stratum corneum, palmitoyl tripeptide-5 is a peptide messenger associated with extracellular-matrix support, and Lactobacillus ferment lysate contributes to topical microbiome equilibrium per emerging dermatology consensus on the cutaneous microbiome.
Specifications
| Brand / Manufacturer | Byra (Byra Beauty Pte Ltd, Singapore) |
|---|---|
| Format | 30 mL leave-on facial serum, glass dropper bottle |
| Key Actives | Bakuchiol; Hyaluronic Acid; Palmitoyl Tripeptide-5; Lactobacillus Ferment Lysate; Bisabolol; Superoxide Dismutase; Pomegranate (Punica granatum) Extract; Tocopherol (Vitamin E) |
| Preservative System | Leuconostoc / Radish Root Ferment Filtrate, Sodium Levulinate, Sodium Anisate (Leucidal-class), Sodium Phytate |
| Free of | Synthetic fragrance, parabens, phenoxyethanol, mineral oils, silicones, sulfates, retinoids (suitable as a retinol alternative) |
| pH | Approximately 5.0–5.5 (compatible with the acid mantle of healthy skin) |
| Manufacturing Standard | Manufactured under ISO 22716:2007 cosmetic Good Manufacturing Practice; ASEAN Cosmetic Directive (ACD) Annex compliance |
| Regulatory Status (Singapore) | Notified to the Singapore HSA via the ASEAN Cosmetic Notification system (per HSA Health Products (Cosmetic Products—ASEAN Cosmetic Directive) Regulations 2007) |
| EU Compliance | EU Cosmetic Regulation (EC) No 1223/2009 ingredient profile alignment |
| Storage | Store below 25°C in original glass bottle; protect from direct sunlight; use within 12 months of opening (PAO 12M) |
Clinical Indications & Use Cases
- Adults seeking a retinol-functional active without retinoid-associated irritation, scaling, or photosensitivity
- Sensitive, perimenopausal, or post-procedure skin requiring a tolerogenic anti-aging regimen
- Pregnancy-compatible alternative for patients counselled to discontinue retinoids during gestation and lactation (clinician confirmation required)
- Stratum corneum dehydration secondary to extended air-conditioned environments (relevant for Singapore office and travel populations)
- Adjunctive routine support after non-ablative laser, microneedling, or chemical peel procedures (per the supervising dermatologist’s post-procedure protocol)
- Daily morning use under a broad-spectrum mineral or hybrid sunscreen for combined photoprotection and antioxidant cover
Frequently Asked Questions
Q: How does bakuchiol differ from retinol, and is the evidence credible?
A: Bakuchiol is a meroterpene phenol from Psoralea corylifolia that engages many of the same downstream gene-expression pathways as retinoids without binding the retinoic acid receptor. The pivotal randomised, double-blind, split-face study (Dhaliwal et al., Br J Dermatol 2019;180:289–296) showed that bakuchiol 0.5% twice daily was comparable to retinol 0.5% daily for wrinkle area and hyperpigmentation reduction over 12 weeks, with significantly less scaling and stinging. Bakuchiol is therefore a reasonable choice for retinoid-intolerant or pregnancy-context patients.
Q: Can this serum be layered with vitamin C or sunscreen?
A: Yes. Apply Rejuvenate Nutri-Serum on cleansed skin and allow 60–90 seconds for absorption before the next step. In a morning routine, follow with antioxidant serums (eg, vitamin C), moisturiser, and broad-spectrum SPF 30+ (preferably SPF 50+ in tropical UV). It is compatible with niacinamide and azelaic acid; avoid simultaneous application with strong AHA/BHA exfoliants to minimise transient irritation.
Q: How long until visible benefit?
A: Hydration and skin smoothness benefits typically appear within 7–14 days of consistent twice-daily application. Wrinkle and pigmentation endpoints, as observed in the Dhaliwal 2019 trial, were measurable at 12 weeks. Document baseline with standardised photography for objective assessment.
Q: Is the product safe in pregnancy and breastfeeding?
A: The product contains no retinoids, salicylates above ACD limits, or hydroquinone. While bakuchiol is generally regarded as safer than retinoids during pregnancy, there are no robust controlled human trials in pregnant populations. Confirm individual suitability with the obstetric or dermatology clinician.
Q: How is the product regulated for sale in Singapore?
A: Cosmetic products in Singapore are regulated by the HSA under the Health Products (Cosmetic Products—ASEAN Cosmetic Directive) Regulations 2007. Each Byra SKU is notified to the HSA prior to placement on the market, follows ASEAN Cosmetic Directive Annex restrictions, and is manufactured under ISO 22716 cosmetic GMP. EMIS+ retains supplier notification numbers and Certificates of Analysis.
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